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XKRY XK related, Y-linked (pseudogene) [ Homo sapiens (human) ]

Gene ID: 9082, updated on 10-Oct-2023

Summary

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Official Symbol
XKRYprovided by HGNC
Official Full Name
XK related, Y-linked (pseudogene)provided by HGNC
Primary source
HGNC:HGNC:18571
See related
Ensembl:ENSG00000290724 MIM:400015; AllianceGenome:HGNC:18571
Gene type
pseudo
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
XKRY1
Summary
This probable pseudogene is located in the nonrecombining portion of the Y chromosome, and is expressed specifically in testis. It is similar to the XK (X-linked Kell blood group precursor) gene, which encodes a putative membrane transport protein. This gene is present as two identical copies within a palindromic region; this record represents the more centromeric copy. [provided by RefSeq, Nov 2020]
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Genomic context

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Location:
Yq11.222
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) Y NC_000024.10 (17768980..17770560, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) Y NC_060948.1 (18675537..18677117, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) Y NC_000024.9 (19880860..19882440, complement)

Chromosome Y - NC_000024.10Genomic Context describing neighboring genes Neighboring gene PTPN13 like Y-linked pseudogene 1 Neighboring gene actin gamma 1 pseudogene 2 Neighboring gene USP9Y pseudogene 23 Neighboring gene RNA, U1 small nuclear 128, pseudogene Neighboring gene USP9Y pseudogene 27

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kell and Kx, two disulfide-linked proteins of the human erythrocyte membrane are phosphorylated in vivo. Carbonnet F, et al. Biochem Biophys Res Commun, 1998 Jun 29. PMID 9647734
  2. Y Chromosome Infertility. Adam MP, et al. , 1993. PMID 20301513
  3. Functional coherence of the human Y chromosome. Lahn BT, et al. Science, 1997 Oct 24. PMID 9381176
  4. The male-specific region of the human Y chromosome is a mosaic of discrete sequence classes. Skaletsky H, et al. Nature, 2003 Jun 19. PMID 12815422
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Spermatogenic failure, Y-linked, 2
MedGen: C1839071 OMIM: 415000 GeneReviews: Y Chromosome Infertility
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Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • X Kell blood group precursor-related, Y-linked
  • X-linked Kx blood group related, Y-linked
  • XK related, Y-linked
  • XK, Kell blood group complex subunit-related, Y-linked
  • testis-specific XK-related protein on Y
  • testis-specific XK-related protein, Y-linked 2

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in single fertilization TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_171026.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC007742
    Related
    ENST00000624960.1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000024.10 Reference GRCh38.p14 Primary Assembly

    Range
    17768980..17770560 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060948.1 Alternate T2T-CHM13v2.0

    Range
    18675537..18677117 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_032917.1: Suppressed sequence

    Description
    NG_032917.1: This RefSeq was removed because the gene type has changed from protein-coding to transcribed pseudogene. The protein-coding reference transcript on this RefSeqGene has been replaced by a non-coding transcript.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14609.1 GenPept UniProtKB/Swiss-Prot:O14609

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
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Research Materials
Miscellaneous