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SEC11C SEC11 homolog C, signal peptidase complex subunit [ Homo sapiens (human) ]

Gene ID: 90701, updated on 5-Mar-2024

Summary

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Official Symbol
SEC11Cprovided by HGNC
Official Full Name
SEC11 homolog C, signal peptidase complex subunitprovided by HGNC
Primary source
HGNC:HGNC:23400
See related
Ensembl:ENSG00000166562 AllianceGenome:HGNC:23400
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SPC21; SPCS4C; SEC11L3
Summary
Predicted to enable peptidase activity. Predicted to be involved in signal peptide processing. Predicted to be located in endoplasmic reticulum membrane. Predicted to be part of signal peptidase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 109.5), thyroid (RPKM 61.5) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
18q21.32
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 18 NC_000018.10 (59139884..59158832)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 18 NC_060942.1 (59341164..59360112)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (56807116..56826064)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 532 Neighboring gene RNA, U2 small nuclear 69, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr18:56635193-56636106 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:56650842-56652041 Neighboring gene O-acyltransferase like, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9489 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56716067-56717037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr18:56717038-56718007 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr18:56729547-56730746 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13406 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13407 Neighboring gene NANOG hESC enhancer GRCh37_chr18:56758336-56758837 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9490 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 9491 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13409 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13408 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13410 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 13412 Neighboring gene signal recognition particle 19kDa pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr18:56855703-56856902 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr18:56886610-56887224 Neighboring gene gastrin releasing peptide

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Signal peptidase 21 suppresses cell proliferation, migration, and invasion via the PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma. Zhang N, et al. PeerJ, 2022. PMID 36275477, Free PMC Article
  2. Signal peptidase complex 18, encoded by SEC11A, contributes to progression via TGF-α secretion in gastric cancer. Oue N, et al. Oncogene, 2014 Jul 24. PMID 23995782
  3. Two subunits of the canine signal peptidase complex are homologous to yeast SEC11 protein. Shelness GS, et al. J Biol Chem, 1990 Jun 5. PMID 2188978
  4. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage. Liaci AM, et al. Mol Cell, 2021 Oct 7. PMID 34388369
  5. The role of assembly in insulin's biosynthesis. Dodson G, et al. Curr Opin Struct Biol, 1998 Apr. PMID 9631292

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Signal peptidase 21 suppresses cell proliferation, migration, and invasion via the PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
    Title: Signal peptidase 21 suppresses cell proliferation, migration, and invasion via the PTEN-PI3K/Akt signaling pathway in lung adenocarcinoma.
  2. Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
    Title: Structure of the human signal peptidase complex reveals the determinants for signal peptide cleavage.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in signal peptide processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal peptide processing IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
part_of signal peptidase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of signal peptidase complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of signal peptidase complex IPI
Inferred from Physical Interaction
more info
 PubMed 

General protein information

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Preferred Names
signal peptidase complex catalytic subunit SEC11C
Names
SEC11-like 3
SEC11-like protein 3
SPase 21 kDa subunit
microsomal signal peptidase 21 kDa subunit
signal peptidase complex 21
NP_001294870.1
NP_150596.1
XP_011524562.1
XP_054175301.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001307941.2 → NP_001294870.1  signal peptidase complex catalytic subunit SEC11C isoform 2

    See identical proteins and their annotated locations for NP_001294870.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR, and lacks an alternate exon in the 3' coding region resulting in a frameshift, compared to variant 1. The encoded isoform (2) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    BM760252, BM789622, BQ417397
    Consensus CDS
    CCDS77193.1
    UniProtKB/TrEMBL
    B4DI03, K7EJQ7
    Related
    ENSP00000465281.1, ENST00000588875.2
    Conserved Domains (1) summary
    cl10465
    Location:34 → 134
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

  2. NM_033280.4 → NP_150596.1  signal peptidase complex catalytic subunit SEC11C isoform 1

    See identical proteins and their annotated locations for NP_150596.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF212233, BM789622
    Consensus CDS
    CCDS11970.1
    UniProtKB/Swiss-Prot
    B2RAA3, Q9BY50
    UniProtKB/TrEMBL
    B4DI03
    Related
    ENSP00000468633.1, ENST00000587834.6
    Conserved Domains (1) summary
    cl10465
    Location:34 → 167
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p14 Primary Assembly

    Range
    59139884..59158832
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011526260.4 → XP_011524562.1  signal peptidase complex catalytic subunit SEC11C isoform X1

    Conserved Domains (1) summary
    cl10465
    Location:31 → 164
    Peptidase_S24_S26; The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060942.1 Alternate T2T-CHM13v2.0

    Range
    59341164..59360112
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054319326.1 → XP_054175301.1  signal peptidase complex catalytic subunit SEC11C isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BY50.3 GenPept UniProtKB/Swiss-Prot:Q9BY50

Gene LinkOut

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