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SYT7 synaptotagmin 7 [ Homo sapiens (human) ]

Gene ID: 9066, updated on 11-Apr-2024

Summary

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Official Symbol
SYT7provided by HGNC
Official Full Name
synaptotagmin 7provided by HGNC
Primary source
HGNC:HGNC:11514
See related
Ensembl:ENSG00000011347 MIM:604146; AllianceGenome:HGNC:11514
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IPCA7; IPCA-7; SYTVII; PCANAP7; SYT-VII
Summary
This gene is a member of the synaptotagmin gene family and encodes a protein similar to other family members that mediate calcium-dependent regulation of membrane trafficking in synaptic transmission. A similar protein in rodents mediates hormone secretion and lysosome exocytosis. In humans, expression of this gene has been associated with prostate cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in brain (RPKM 15.4), prostate (RPKM 13.8) and 12 other tissues See more
Orthologs
mouse all
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Genomic context

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See SYT7 in Genome Data Viewer
Location:
11q12.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (61513714..61588387, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (61502594..61577283, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (61281186..61348548, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61280313-61280926 Neighboring gene leucine rich repeat containing 10B Neighboring gene microRNA 4488 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61297435-61297934 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61301414-61302353 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61302354-61303292 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3394 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3395 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3396 Neighboring gene uncharacterized LOC105369331 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61354237-61354816 Neighboring gene uncharacterized LOC101927495 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61355975-61356553 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61366831-61367498 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61368167-61368834 Neighboring gene ribosomal protein lateral stalk subunit P0 pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61393636-61394198 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61394199-61394759 Neighboring gene Sharpr-MPRA regulatory region 3465 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:61396115-61397096 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:61406067-61406567 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:61406607-61407134

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. SYT7 plays a role in promoting thyroid cancer by mediating HMGB3 ubiquitination. Dong S, et al. Endocr Relat Cancer, 2022 Mar 1. PMID 35073278
  2. Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma. Jin H, et al. Future Oncol, 2020 Dec. PMID 33052751
  3. High SYT7 expression is associated with poor prognosis in human non-small cell lung carcinoma. Han Q, et al. Pathol Res Pract, 2020 Sep. PMID 32825966
  4. Silencing of synaptotagmin 7 regulates osteosarcoma cell proliferation, apoptosis, and migration. Wu Z, et al. Histol Histopathol, 2020 Mar. PMID 31631310
  5. SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells. Kanda M, et al. Oncogene, 2018 Sep. PMID 29858600

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SYT7 is a key player in increasing exosome secretion and promoting angiogenesis in non-small-cell lung cancer.
    Title: SYT7 is a key player in increasing exosome secretion and promoting angiogenesis in non-small-cell lung cancer.
  2. SYT7 plays a role in promoting thyroid cancer by mediating HMGB3 ubiquitination.
    Title: SYT7 plays a role in promoting thyroid cancer by mediating HMGB3 ubiquitination.
  3. Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma.
    Title: Syt-7 overexpression predicts poor prognosis and promotes cell proliferation in hepatocellular carcinoma.
  4. High SYT7 expression is associated with poor prognosis in human non-small cell lung carcinoma.
    Title: High SYT7 expression is associated with poor prognosis in human non-small cell lung carcinoma.
  5. Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity.
    Title: Synaptotagmin-7 deficiency induces mania-like behavioral abnormalities through attenuating GluN2B activity.
  6. Silencing of synaptotagmin 7 regulates osteosarcoma cell proliferation, apoptosis, and migration.
    Title: Silencing of synaptotagmin 7 regulates osteosarcoma cell proliferation, apoptosis, and migration.
  7. The Syt7 mRNA level was significantly attenuated in the bipolar disorder patient plasma compared to the healthy controls.
    Title: Synaptotagmin-7 is a key factor for bipolar-like behavioral abnormalities in mice.
  8. Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7
    Title: Membrane-Binding Cooperativity and Coinsertion by C2AB Tandem Domains of Synaptotagmins 1 and 7.
  9. The oncogenic role of SYT7 in lung cancer.the oncogenic roles of SYT7 in lung cancer.SYT7 interacts with P53 and to potentiate the interaction between P53 and MDM2.
    Title: Synaptotagmin-7, a binding protein of P53, inhibits the senescence and promotes the tumorigenicity of lung cancer cells.
  10. Transcriptome data identified the overexpression of synaptotagmin VII (SYT7) in gastric cancer tissues with hepatic metastasis
    Title: SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (20)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of plasma N6 polyunsaturated fatty acids within the cohorts for heart and aging research in genomic epidemiology consortium.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC150517

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SNARE binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-dependent phospholipid binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables calcium-dependent phospholipid binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables calmodulin binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables clathrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4,5-bisphosphate binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylserine binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables syntaxin binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in calcium ion regulated lysosome exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in calcium ion-regulated exocytosis of neurotransmitter IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in calcium ion-regulated exocytosis of neurotransmitter ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in phagosome-lysosome fusion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in plasma membrane repair ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of calcium ion-dependent exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of bone remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of glucagon secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of insulin secretion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of phagocytosis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in short-term synaptic potentiation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in synaptic vesicle recycling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in vesicle fusion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vesicle-mediated cholesterol transport ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in dense core granule IEA
Inferred from Electronic Annotation
more info
  
located_in early phagosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in extracellular exosome HDA PubMed 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
  
located_in lysosomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lysosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in peroxisomal membrane IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in phagocytic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in presynaptic membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
synaptotagmin-7
Names
prostate cancer-associated protein 7
synaptotagmin VII

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252065.2 → NP_001238994.1  synaptotagmin-7 isoform 1

    See identical proteins and their annotated locations for NP_001238994.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AP002754, AP003108, BC042495, BC125171, BE644642, BM675410, BQ447018
    Consensus CDS
    CCDS58139.1
    UniProtKB/Swiss-Prot
    O43581
    Related
    ENSP00000444201.1, ENST00000540677.5
    Conserved Domains (2) summary
    cd08386
    Location:210 → 334
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:342 → 477
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  2. NM_001300773.2 → NP_001287702.1  synaptotagmin-7 isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains an alternate in-frame exon in place of another alternate in-frame exon compared to variant 1. The resulting isoform (3) has an alternate 44 aa internal segment in place of an alternate 75 aa internal segment compared to isoform 1.
    Source sequence(s)
    AP002754, AP003108, BC042495, BC125170, BE644642, BQ447018, CA868518
    Consensus CDS
    CCDS73298.1
    UniProtKB/Swiss-Prot
    O43581
    Related
    ENSP00000444568.1, ENST00000542836.5
    Conserved Domains (2) summary
    cd08386
    Location:179 → 303
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:311 → 446
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  3. NM_001365809.2 → NP_001352738.1  synaptotagmin-7 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AP002754, AP003108, AP003559
    Consensus CDS
    CCDS91487.1
    Related
    ENSP00000439694.1, ENST00000539008.6
    Conserved Domains (3) summary
    cd08386
    Location:418 → 542
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:550 → 685
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    PHA03307
    Location:143 → 310
    PHA03307; transcriptional regulator ICP4; Provisional

  4. NM_001370210.1 → NP_001357139.1  synaptotagmin-7 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AP003108, AP003559
    Conserved Domains (2) summary
    cd08386
    Location:231 → 355
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cl14603
    Location:363 → 466
    C2; C2 domain

  5. NM_001370211.1 → NP_001357140.1  synaptotagmin-7 isoform 6

    Status: REVIEWED

    Source sequence(s)
    AP002754, AP003108, AP003559
    Conserved Domains (2) summary
    cd08386
    Location:135 → 259
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cl14603
    Location:267 → 370
    C2; C2 domain

  6. NM_001411007.1 → NP_001397936.1  synaptotagmin-7 isoform 7

    Status: REVIEWED

    Source sequence(s)
    AP002754, AP003108, AP003559
    Consensus CDS
    CCDS91486.1
    Related
    ENSP00000437720.1, ENST00000535826.5

  7. NM_004200.4 → NP_004191.2  synaptotagmin-7 isoform 2

    See identical proteins and their annotated locations for NP_004191.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region but maintains the reading frame, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    AP002754, AP003108, BC042495, BC125170, BE644642, BM675410, BQ447018
    Consensus CDS
    CCDS31577.1
    UniProtKB/Swiss-Prot
    F5GZC2, F5GZU9, F5H126, F5H1N2, F5H6C1, O43581, Q08AH6
    Related
    ENSP00000263846.4, ENST00000263846.8
    Conserved Domains (2) summary
    cd08386
    Location:135 → 259
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:267 → 402
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    61513714..61588387 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011545343.3 → XP_011543645.1  synaptotagmin-7 isoform X12

    Conserved Domains (2) summary
    cd08386
    Location:141 → 265
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:273 → 408
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  2. XM_011545340.3 → XP_011543642.1  synaptotagmin-7 isoform X8

    Conserved Domains (2) summary
    cd08386
    Location:216 → 340
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:348 → 483
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  3. XM_011545337.3 → XP_011543639.1  synaptotagmin-7 isoform X3

    Conserved Domains (2) summary
    cd08386
    Location:380 → 504
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:512 → 647
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  4. XM_011545341.3 → XP_011543643.1  synaptotagmin-7 isoform X9

    Conserved Domains (2) summary
    cd08386
    Location:185 → 309
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:317 → 452
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  5. XM_011545338.3 → XP_011543640.1  synaptotagmin-7 isoform X5

    Conserved Domains (2) summary
    cd08386
    Location:349 → 473
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:481 → 616
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  6. XM_011545339.3 → XP_011543641.1  synaptotagmin-7 isoform X7

    Conserved Domains (2) summary
    cd08386
    Location:260 → 384
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:392 → 527
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  7. XM_011545336.3 → XP_011543638.1  synaptotagmin-7 isoform X2

    Conserved Domains (2) summary
    cd08386
    Location:383 → 507
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:515 → 650
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  8. XM_011545335.3 → XP_011543637.1  synaptotagmin-7 isoform X1

    Conserved Domains (2) summary
    cd08386
    Location:424 → 548
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:556 → 691
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  9. XM_005274384.3 → XP_005274441.1  synaptotagmin-7 isoform X4

    Conserved Domains (3) summary
    cd08386
    Location:374 → 498
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:506 → 641
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7
    PHA03307
    Location:99 → 266
    PHA03307; transcriptional regulator ICP4; Provisional

  10. XM_005274385.5 → XP_005274442.1  synaptotagmin-7 isoform X6

    UniProtKB/Swiss-Prot
    O43581
    Related
    ENSP00000444019.1, ENST00000542670.5
    Conserved Domains (2) summary
    cd08386
    Location:343 → 467
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:475 → 610
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  11. XM_005274387.5 → XP_005274444.1  synaptotagmin-7 isoform X10

    Conserved Domains (2) summary
    cd08386
    Location:181 → 305
    C2A_Synaptotagmin-7; C2A domain first repeat present in Synaptotagmin 7
    cd08405
    Location:313 → 448
    C2B_Synaptotagmin-7; C2 domain second repeat present in Synaptotagmin 7

  12. XM_011545342.3 → XP_011543644.1  synaptotagmin-7 isoform X11

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    61502594..61577283 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054370458.1 → XP_054226433.1  synaptotagmin-7 isoform X9

  2. XM_054370461.1 → XP_054226436.1  synaptotagmin-7 isoform X12

  3. XM_054370456.1 → XP_054226431.1  synaptotagmin-7 isoform X7

  4. XM_054370450.1 → XP_054226425.1  synaptotagmin-7 isoform X1

  5. XM_054370452.1 → XP_054226427.1  synaptotagmin-7 isoform X3

  6. XM_054370451.1 → XP_054226426.1  synaptotagmin-7 isoform X2

  7. XM_054370454.1 → XP_054226429.1  synaptotagmin-7 isoform X5

  8. XM_054370457.1 → XP_054226432.1  synaptotagmin-7 isoform X8

  9. XM_054370453.1 → XP_054226428.1  synaptotagmin-7 isoform X4

  10. XM_054370455.1 → XP_054226430.1  synaptotagmin-7 isoform X6

  11. XM_054370459.1 → XP_054226434.1  synaptotagmin-7 isoform X10

  12. XM_054370460.1 → XP_054226435.1  synaptotagmin-7 isoform X11

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43581.3 GenPept UniProtKB/Swiss-Prot:O43581

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