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ZNF835 zinc finger protein 835 [ Homo sapiens (human) ]

Gene ID: 90485, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF835provided by HGNC
Official Full Name
zinc finger protein 835provided by HGNC
Primary source
HGNC:HGNC:34332
See related
Ensembl:ENSG00000127903 AllianceGenome:HGNC:34332
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BC37295_3
Summary
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary (RPKM 1.2), brain (RPKM 0.9) and 20 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.43
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (56661980..56671757, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (59756128..59765893, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (57173348..57183125, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11070 Neighboring gene ZNF71-SMIM17 readthrough (NMD candidate) Neighboring gene zinc finger protein 71 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:57128366-57128584 Neighboring gene Sharpr-MPRA regulatory region 15209 Neighboring gene small integral membrane protein 17 Neighboring gene uncharacterized LOC105372473 Neighboring gene uncharacterized LOC105372472 Neighboring gene olfactory receptor family 5 subfamily AH member 1 pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Heterozygous deletion of chromosome 17p renders prostate cancer vulnerable to inhibition of RNA polymerase II. Li Y, et al. Nat Commun, 2018 Oct 22. PMID 30349055, Free PMC Article
  2. A human skeletal muscle interactome centered on proteins involved in muscular dystrophies: LGMD interactome. Blandin G, et al. Skelet Muscle, 2013 Feb 15. PMID 23414517, Free PMC Article
  3. A reference map of the human binary protein interactome. Luck K, et al. Nature, 2020 Apr. PMID 32296183, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 835

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001005850.3 → NP_001005850.2  zinc finger protein 835

    See identical proteins and their annotated locations for NP_001005850.2

    Status: VALIDATED

    Source sequence(s)
    AC007228, AK023017, AK299565, DB536138, DC382896
    Consensus CDS
    CCDS56105.1
    UniProtKB/Swiss-Prot
    B7Z5Y0, G3V1S0, Q9Y2P0
    Related
    ENSP00000444747.1, ENST00000537055.4
    Conserved Domains (5) summary
    COG5048
    Location:136 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:140 → 160
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:474 → 496
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:348 → 373
    zf-H2C2_2; Zinc-finger double domain
    cl00955
    Location:178 → 243
    Ribosomal_L34e; Ribosomal protein L34e

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    56661980..56671757 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259382.3 → XP_005259439.1  zinc finger protein 835 isoform X1

    See identical proteins and their annotated locations for XP_005259439.1

    UniProtKB/Swiss-Prot
    B7Z5Y0, G3V1S0, Q9Y2P0
    Conserved Domains (5) summary
    COG5048
    Location:136 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:140 → 160
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:474 → 496
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:348 → 373
    zf-H2C2_2; Zinc-finger double domain
    cl00955
    Location:178 → 243
    Ribosomal_L34e; Ribosomal protein L34e

  2. XM_005259383.4 → XP_005259440.1  zinc finger protein 835 isoform X1

    See identical proteins and their annotated locations for XP_005259440.1

    UniProtKB/Swiss-Prot
    B7Z5Y0, G3V1S0, Q9Y2P0
    Conserved Domains (5) summary
    COG5048
    Location:136 → 487
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:140 → 160
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:474 → 496
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:348 → 373
    zf-H2C2_2; Zinc-finger double domain
    cl00955
    Location:178 → 243
    Ribosomal_L34e; Ribosomal protein L34e

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    59756128..59765893 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322553.1 → XP_054178528.1  zinc finger protein 835 isoform X1

  2. XM_054322552.1 → XP_054178527.1  zinc finger protein 835 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y2P0.2 GenPept UniProtKB/Swiss-Prot:Q9Y2P0

Gene LinkOut

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