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UNC5A unc-5 netrin receptor A [ Homo sapiens (human) ]

Gene ID: 90249, updated on 5-Mar-2024

Summary

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Official Symbol
UNC5Aprovided by HGNC
Official Full Name
unc-5 netrin receptor Aprovided by HGNC
Primary source
HGNC:HGNC:12567
See related
Ensembl:ENSG00000113763 MIM:607869; AllianceGenome:HGNC:12567
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UNC5H1
Summary
UNC5A belongs to a family of netrin-1 (MIM 601614) receptors thought to mediate the chemorepulsive effect of netrin-1 on specific axons. For more information on UNC5 proteins, see UNC5C (MIM 603610).[supplied by OMIM, Apr 2004]
Expression
Biased expression in brain (RPKM 7.1) and adrenal (RPKM 2.6) See more
Orthologs
mouse all
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Genomic context

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Location:
5q35.2
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (176810559..176880898)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (177357147..177426724)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (176237560..176307899)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176087757-176088480 Neighboring gene uncharacterized LOC124901144 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176093385-176093611 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176098601-176099166 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr5:176099167-176099730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176106874-176107834 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176107835-176108794 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176119741-176120285 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176124309-176125132 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176126779-176127601 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176139283-176140243 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176148139-176148638 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176152218-176152749 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176152750-176153280 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176160291-176161220 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176159360-176160290 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176167545-176168254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176170772-176171740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176174798-176175456 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176176117-176176775 Neighboring gene long intergenic non-protein coding RNA 1574 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176211747-176212340 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176212935-176213528 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:176214607-176215806 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176219277-176220119 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176220120-176220961 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176225159-176226105 Neighboring gene MPRA-validated peak5589 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16665 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 23691 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176257203-176258159 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176271727-176272558 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176284513-176285014 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:176295664-176296411 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176299555-176299736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176302473-176303396 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:176306956-176307321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:176314417-176314917 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176327167-176327668 Neighboring gene hexokinase 3 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:176370315-176371173 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr5:176371174-176372031 Neighboring gene ubiquitin interaction motif containing 1 Neighboring gene uncharacterized LOC124901145 Neighboring gene MPRA-validated peak5592 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16666 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16667 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16668 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176449401-176449938 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:176449939-176450475 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16670 Neighboring gene zinc finger protein 346 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:176488686-176489885

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Reciprocal antagonism between the netrin-1 receptor uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus. Plissonnier ML, et al. Oncogene, 2017 Nov 30. PMID 28783179
  2. DNA damage-inducible gene, UNC5A, functions as a tumor-suppressor in bladder cancer. Zhu Y, et al. Tumour Biol, 2014 Jul. PMID 24737586
  3. Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes. Barnault R, et al. Biochem Biophys Res Commun, 2018 Jan 22. PMID 29277614
  4. Characterization of the receptors for axon guidance factor netrin-4 and identification of the binding domains. Qin S, et al. Mol Cell Neurosci, 2007 Feb. PMID 17174565
  5. p53RDL1 regulates p53-dependent apoptosis. Tanikawa C, et al. Nat Cell Biol, 2003 Mar. PMID 12598906

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These studies reveal an unexpected role of the axon guidance receptor UNC5A in fine-tuning ERalpha and EGFR signaling and the luminal progenitor status of hormone-sensitive breast cancers. Furthermore, UNC5A knockdown cells provide an ideal model system to investigate metastasis of ERalpha(+) breast cancers
    Title: Dependence receptor UNC5A restricts luminal to basal breast cancer plasticity and metastasis.
  2. The results suggest that netrin-1 promotes glioma cell proliferation by activating NF-kappaB signaling via UNC5A.
    Title: Netrin-1 promotes glioma growth by activating NF-κB via UNC5A.
  3. Such data indicate that cooperation between the UPR and UNC5A depletion as previously observed by ourselves in HCC patients samples may foster liver cancer development and growth.
    Title: Hepatocellular carcinoma-associated depletion of the netrin-1 receptor Uncoordinated Phenotype-5A (UNC5A) skews the hepatic unfolded protein response towards prosurvival outcomes.
  4. UNC5A is capable of impeding autophagy and promoting HCV restriction through specific impact on virion infectivity, in a cell death-independent and DAPK-related manner.
    Title: Reciprocal antagonism between the netrin-1 receptor uncoordinated-phenotype-5A (UNC5A) and the hepatitis C virus.
  5. FANCC interferes with UNC5A's functions in apoptosis and suggest that FANCC may participate in developmental processes through association with the dependence receptor UNC5A.
    Title: The Fanconi anemia group C protein interacts with uncoordinated 5A and delays apoptosis.
  6. these data suggest an important role for UNC5A, a candidate tumor suppressor, in predicting response to DNA damage induced by chemotherapeutic drug and regulating cell death in bladder cancer
    Title: DNA damage-inducible gene, UNC5A, functions as a tumor-suppressor in bladder cancer.
  7. UNC5A is a novel transcriptional target of p53 and plays a role in p53-dependent apoptosis
    Title: Identification of UNC5A as a novel transcriptional target of tumor suppressor p53 and a regulator of apoptosis.
  8. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
  9. Observational study of gene-disease association. (HuGE Navigator)
    Title: Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
  10. may represent tumor suppressor that inhibit tumor extension outside the region of netrin-1 availability by inducing apoptosis
    Title: The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitment.
Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ16449, KIAA1976

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables netrin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anterior/posterior axon guidance IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in netrin-activated signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in membrane raft IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
netrin receptor UNC5A
Names
netrin receptor Unc5h1
protein unc-5 homolog 1
protein unc-5 homolog A
unc-5 homolog 1
unc-5 homolog A
unc5 (C.elegans homolog) a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_133369.3 → NP_588610.2  netrin receptor UNC5A precursor

    See identical proteins and their annotated locations for NP_588610.2

    Status: VALIDATED

    Source sequence(s)
    AC091902, BC009333, BC033727, BI818609, BM712478
    Consensus CDS
    CCDS34299.1
    UniProtKB/Swiss-Prot
    B2RXE6, Q6ZN44, Q8TF26, Q96GP4
    Related
    ENSP00000332737.4, ENST00000329542.9
    Conserved Domains (5) summary
    smart00218
    Location:439 → 542
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245 → 293
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151 → 239
    I-set; Immunoglobulin I-set domain
    cd08800
    Location:755 → 838
    Death_UNC5A; Death domain found in Uncoordinated-5A
    cl11960
    Location:153 → 239
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    176810559..176880898
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006714928.2 → XP_006714991.1  netrin receptor UNC5A isoform X3

    UniProtKB/TrEMBL
    H0Y8R2
    Related
    ENSP00000421795.2, ENST00000509580.2
    Conserved Domains (5) summary
    smart00218
    Location:495 → 598
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245 → 296
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151 → 239
    I-set; Immunoglobulin I-set domain
    cd08800
    Location:811 → 894
    Death_UNC5A; Death domain found in Uncoordinated-5A
    cl11960
    Location:153 → 239
    Ig; Immunoglobulin domain

  2. XM_011534686.2 → XP_011532988.1  netrin receptor UNC5A isoform X1

    Conserved Domains (4) summary
    smart00218
    Location:495 → 598
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245 → 296
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151 → 239
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:153 → 239
    Ig; Immunoglobulin domain

  3. XM_006714927.2 → XP_006714990.1  netrin receptor UNC5A isoform X2

    Conserved Domains (4) summary
    smart00218
    Location:439 → 542
    ZU5; Domain present in ZO-1 and Unc5-like netrin receptors
    smart00209
    Location:245 → 293
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151 → 239
    I-set; Immunoglobulin I-set domain
    cl11960
    Location:153 → 239
    Ig; Immunoglobulin domain

  4. XM_011534687.3 → XP_011532989.1  netrin receptor UNC5A isoform X4

    Conserved Domains (4) summary
    smart00209
    Location:245 → 296
    TSP1; Thrombospondin type 1 repeats
    pfam07679
    Location:151 → 239
    I-set; Immunoglobulin I-set domain
    cl02517
    Location:495 → 515
    ZU5; ZU5 domain
    cl11960
    Location:153 → 239
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    177357147..177426724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054353750.1 → XP_054209725.1  netrin receptor UNC5A isoform X3

    UniProtKB/TrEMBL
    H0Y8R2

  2. XM_054353748.1 → XP_054209723.1  netrin receptor UNC5A isoform X1

  3. XM_054353749.1 → XP_054209724.1  netrin receptor UNC5A isoform X2

  4. XM_054353751.1 → XP_054209726.1  netrin receptor UNC5A isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6ZN44.3 GenPept UniProtKB/Swiss-Prot:Q6ZN44

Gene LinkOut

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