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KLC4 kinesin light chain 4 [ Homo sapiens (human) ]

Gene ID: 89953, updated on 5-Mar-2024

Summary

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Official Symbol
KLC4provided by HGNC
Official Full Name
kinesin light chain 4provided by HGNC
Primary source
HGNC:HGNC:21624
See related
Ensembl:ENSG00000137171 AllianceGenome:HGNC:21624
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KNSL8; bA387M24.3
Summary
Predicted to be located in cytoplasm and microtubule. Predicted to be part of kinesin complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in duodenum (RPKM 24.3), small intestine (RPKM 22.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
6p21.1
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43059631..43075093)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (42888702..42903839)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43027369..43042831)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901318 Neighboring gene RNA, 7SL, cytoplasmic 403, pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43013559-43013750 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43018382-43018882 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43018883-43019383 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43019933-43020768 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17217 Neighboring gene cullin 7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24587 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:43027385-43028336 Neighboring gene mitochondrial ribosomal protein L2 Neighboring gene Sharpr-MPRA regulatory region 10128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43038920-43039420 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43043187-43043710 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17218 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43049243-43049446 Neighboring gene KLC4 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43050481-43051047 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43051048-43051613 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43057365-43057958 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr6:43057959-43058553 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43058554-43059147 Neighboring gene protein tyrosine kinase 7 (inactive) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24590 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24591 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43086921-43087840 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43087841-43088760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43099803-43100304 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43100305-43100804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24592 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43138211-43138940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17219 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43139967-43140935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24594 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43145601-43146102 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43146103-43146602 Neighboring gene serum response factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network. Baek JH, et al. Cell Death Dis, 2020 May 26. PMID 32457423, Free PMC Article
  2. Hereditary spastic paraplegia with recessive trait caused by mutation in KLC4 gene. Bayrakli F, et al. J Hum Genet, 2015 Dec. PMID 26423925
  3. Insight into the molecular mechanism of the multitasking kinesin-8 motor. Peters C, et al. EMBO J, 2010 Oct 20. PMID 20818331, Free PMC Article
  4. SETD3 reduces KLC4 expression to improve the sensitization of cervical cancer cell to radiotherapy. Li Q, et al. Biochem Biophys Res Commun, 2019 Aug 27. PMID 31235251
  5. Hereditary Spastic Paraplegia Overview. Adam MP, et al. , 1993. PMID 20301682

See all (61) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network.
    Title: Kinesin light chain 4 as a new target for lung cancer chemoresistance via targeted inhibition of checkpoint kinases in the DNA repair network.
  2. Findings indicate that SET domain protein 3 (SETD3) down-regulated the expression of kinesin light chain 4 (KLC4), contributing to the radiosensitivity of cervical cancer cells, suggesting targeting SETD3 might be a potential strategy for the clinical management of cervical cancer.
    Title: SETD3 reduces KLC4 expression to improve the sensitization of cervical cancer cell to radiotherapy.
  3. The association of a KLC4 mutation with spastic paraplegia identifies a new locus for the disease.
    Title: Hereditary spastic paraplegia with recessive trait caused by mutation in KLC4 gene.
  4. Data reveal aspects of the molecular mechanism of kinesin-8 motors that contribute to their unique dual motile and depolymerising functions, which are adapted to control microtubule length.
    Title: Insight into the molecular mechanism of the multitasking kinesin-8 motor.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC111777

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables kinesin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in microtubule-based movement IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of kinesin complex IEA
Inferred from Electronic Annotation
more info
  
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
kinesin light chain 4
Names
kinesin-like protein 8

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289034.2 → NP_001275963.1  kinesin light chain 4 isoform a

    See identical proteins and their annotated locations for NP_001275963.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.
    Source sequence(s)
    AK056393, BC080637, BX640717
    Consensus CDS
    CCDS4883.1
    UniProtKB/Swiss-Prot
    B3KNY4, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6, Q9NSK0
    Related
    ENSP00000418031.1, ENST00000479388.5
    Conserved Domains (3) summary
    TIGR02168
    Location:33 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 368
    TPR_12; Tetratricopeptide repeat

  2. NM_001289035.2 → NP_001275964.1  kinesin light chain 4 isoform d

    See identical proteins and their annotated locations for NP_001275964.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) contains an alternate 5' terminal exon, initiates translation at a downstream start codon and lacks an alternate in-frame exon in the 5' coding region, compared to variant 3. It encodes isoform d, which is shorter than isoform b.
    Source sequence(s)
    AK297433, BC080637
    Consensus CDS
    CCDS75459.1
    UniProtKB/Swiss-Prot
    Q9NSK0
    Related
    ENSP00000395806.2, ENST00000453940.6
    Conserved Domains (2) summary
    sd00006
    Location:218 → 246
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:217 → 291
    TPR_12; Tetratricopeptide repeat

  3. NM_138343.4 → NP_612352.1  kinesin light chain 4 isoform c

    See identical proteins and their annotated locations for NP_612352.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and the 5' coding region and contains a 3' terminal exon that extends past a splice site, compared to variant 3. It encodes isoform c, which is shorter and has a distinct C-terminus, compared to isoform b.
    Source sequence(s)
    BC012357, DA782235
    Consensus CDS
    CCDS47429.1
    UniProtKB/Swiss-Prot
    Q9NSK0
    Related
    ENSP00000410358.2, ENST00000458460.6
    Conserved Domains (3) summary
    TIGR02168
    Location:33 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:212 → 239
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:210 → 285
    TPR_12; Tetratricopeptide repeat

  4. NM_201521.3 → NP_958929.1  kinesin light chain 4 isoform a

    See identical proteins and their annotated locations for NP_958929.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.
    Source sequence(s)
    BC080637, DA782235
    Consensus CDS
    CCDS4883.1
    UniProtKB/Swiss-Prot
    B3KNY4, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6, Q9NSK0
    Related
    ENSP00000340221.5, ENST00000347162.10
    Conserved Domains (3) summary
    TIGR02168
    Location:33 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 368
    TPR_12; Tetratricopeptide repeat

  5. NM_201522.3 → NP_958930.1  kinesin light chain 4 isoform a

    See identical proteins and their annotated locations for NP_958930.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 3. Variants 1, 2 and 5 encode the same isoform (a), which has a shorter N-terminus, compared to isoform b.
    Source sequence(s)
    AK055293, AK056393, BC080637, DA835055
    Consensus CDS
    CCDS4883.1
    UniProtKB/Swiss-Prot
    B3KNY4, B3KPI3, B3KSQ3, B4DME9, Q66K28, Q96EG6, Q9NSK0
    Related
    ENSP00000377620.2, ENST00000394056.6
    Conserved Domains (3) summary
    TIGR02168
    Location:33 → 148
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    sd00006
    Location:295 → 323
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:294 → 368
    TPR_12; Tetratricopeptide repeat

  6. NM_201523.3 → NP_958931.1  kinesin light chain 4 isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes the longest isoform (b).
    Source sequence(s)
    AK094102, BC080637
    Consensus CDS
    CCDS4882.1
    UniProtKB/Swiss-Prot
    Q9NSK0
    Related
    ENSP00000259708.3, ENST00000259708.7
    Conserved Domains (3) summary
    sd00006
    Location:313 → 341
    TPR; TPR repeat [structural motif]
    pfam13424
    Location:312 → 386
    TPR_12; Tetratricopeptide repeat
    cl25732
    Location:51 → 166
    SMC_N; RecF/RecN/SMC N terminal domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    43059631..43075093
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    42888702..42903839
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NSK0.3 GenPept UniProtKB/Swiss-Prot:Q9NSK0

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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