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SIGLEC10 sialic acid binding Ig like lectin 10 [ Homo sapiens (human) ]

Gene ID: 89790, updated on 3-Apr-2024

Summary

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Official Symbol
SIGLEC10provided by HGNC
Official Full Name
sialic acid binding Ig like lectin 10provided by HGNC
Primary source
HGNC:HGNC:15620
See related
Ensembl:ENSG00000142512 MIM:606091; AllianceGenome:HGNC:15620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SLG2; PRO940; SIGLEC-10
Summary
SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).[supplied by OMIM, Jul 2002]
Expression
Biased expression in appendix (RPKM 14.2), spleen (RPKM 13.0) and 12 other tissues See more
Orthologs
all
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Genomic context

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See SIGLEC10 in Genome Data Viewer
Location:
19q13.41
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51410020..51417642, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54498651..54506273, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51913274..51920896, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene chromosome 19 open reading frame 84 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:51897116-51897712 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15015 Neighboring gene NIFK pseudogene 6 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15016 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:51912204-51912704 Neighboring gene SIGLEC10 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15017 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15018 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51941886-51942056 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15019 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15020 Neighboring gene sialic acid binding Ig like lectin 8 Neighboring gene sialic acid binding Ig like lectin 25, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage. Gao S, et al. Dis Markers, 2022. PMID 36188429, Free PMC Article
  2. Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples. Zhang C, et al. Front Med, 2022 Aug. PMID 35075579
  3. A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides. Alborzian Deh Sheikh A, et al. J Autoimmun, 2021 Jan. PMID 33223341
  4. Siglec-10 expression is up-regulated in activated human CD4(+) T cells. Bandala-Sanchez E, et al. Hum Immunol, 2020 Feb-Mar. PMID 32046870
  5. Siglec-10 is associated with survival and natural killer cell dysfunction in hepatocellular carcinoma. Zhang P, et al. J Surg Res, 2015 Mar. PMID 25450598

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Siglec10 Expression on Tumor-associated Macrophages Is an Independent Prognostic Factor in Stage I Lung Adenocarcinoma.
    Title: Siglec10 Expression on Tumor-associated Macrophages Is an Independent Prognostic Factor in Stage I Lung Adenocarcinoma.
  2. Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's disease: potential early diagnostic indicators.
    Title: Gene expression patterns of CRYM and SIGLEC10 in Alzheimer's disease: potential early diagnostic indicators.
  3. High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
    Title: High Expression and Significance of Siglec10/CD24 in Unexplained Missed Abortion.
  4. Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage.
    Title: Long-Term Elevated Siglec-10 in Cerebral Spinal Fluid Heralds Better Prognosis for Patients with Aneurysmal Subarachnoid Hemorrhage.
  5. Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples.
    Title: Innate immune checkpoint Siglec10 in cancers: mining of comprehensive omics data and validation in patient samples.
  6. A Guillain-Barre syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.
    Title: A Guillain-Barré syndrome-associated SIGLEC10 rare variant impairs its recognition of gangliosides.
  7. Novel insights into the function of CD24: A driving force in cancer.
    Title: Novel insights into the function of CD24: A driving force in cancer.
  8. Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10.
    Title: Molecular Mechanism of Tumor Cell Immune Escape Mediated by CD24/Siglec-10.
  9. Siglec-10 expression is up-regulated in activated human CD4(+) T cells.
    Title: Siglec-10 expression is up-regulated in activated human CD4(+) T cells.
  10. Genetic ablation of either CD24 or Siglec-10, as well as blockade of the CD24-Siglec-10 interaction using monoclonal antibodies, robustly augment the phagocytosis of all CD24-expressing human tumours that we tested. Genetic ablation and therapeutic blockade of CD24 resulted in a macrophage-dependent reduction of tumour growth in vivo and an increase in survival time.
    Title: CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC126774

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH2 domain binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sialic acid binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adaptive immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of inflammatory response to wounding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
sialic acid-binding Ig-like lectin 10
Names
sialic acid binding Ig-like lectin 10 Ig-like lectin 7
siglec-like gene 2
siglec-like protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001171156.2 → NP_001164627.1  sialic acid-binding Ig-like lectin 10 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001164627.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame segment in the CDS, as compared to variant 1. The resulting isoform (2) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54303.1
    UniProtKB/TrEMBL
    B7ZL06
    Related
    ENSP00000389132.2, ENST00000439889.6
    Conserved Domains (4) summary
    cd00096
    Location:320 → 381
    Ig; Immunoglobulin domain
    smart00408
    Location:211 → 272
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:309 → 384
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  2. NM_001171157.2 → NP_001164628.1  sialic acid-binding Ig-like lectin 10 isoform 3 precursor

    See identical proteins and their annotated locations for NP_001164628.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (3) lacks an internal segment, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54305.1
    UniProtKB/TrEMBL
    B7ZL04
    Related
    ENSP00000342389.5, ENST00000353836.9
    Conserved Domains (3) summary
    cd00096
    Location:146 → 150
    Ig; Ig strand A [structural motif]
    cd05712
    Location:21 → 140
    IgV_CD33; Immunoglobulin Variable (IgV) domain at the N-terminus of CD33 and related Siglecs (sialic acid-binding Ig-like lectins)
    cl11960
    Location:146 → 233
    Ig; Immunoglobulin domain

  3. NM_001171158.2 → NP_001164629.1  sialic acid-binding Ig-like lectin 10 isoform 4 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an in-frame segment and an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (4) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54304.1
    UniProtKB/TrEMBL
    B7ZL04
    Related
    ENSP00000414324.2, ENST00000436984.6
    Conserved Domains (4) summary
    cd00096
    Location:330 → 391
    Ig; Immunoglobulin domain
    smart00408
    Location:221 → 282
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:319 → 394
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  4. NM_001171159.2 → NP_001164630.1  sialic acid-binding Ig-like lectin 10 isoform 5 precursor

    See identical proteins and their annotated locations for NP_001164630.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an in-frame segment and an in-frame exon in the CDS, as compared to variant 1. The resulting isoform (5) lacks two internal segments, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54302.1
    UniProtKB/TrEMBL
    B7ZL04
    Related
    ENSP00000408387.2, ENST00000441969.7
    Conserved Domains (4) summary
    cd00096
    Location:320 → 381
    Ig; Immunoglobulin domain
    smart00408
    Location:211 → 272
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:309 → 384
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  5. NM_001171161.2 → NP_001164632.1  sialic acid-binding Ig-like lectin 10 isoform 7 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) lacks an in-frame segment and two in-frame exons in the CDS, as compared to variant 1. The resulting isoform (7) lacks three internal segments, as compared to isoform 1.
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS54301.1
    UniProtKB/Swiss-Prot
    Q96LC7
    Related
    ENSP00000395475.2, ENST00000442846.7
    Conserved Domains (3) summary
    cd00096
    Location:230 → 291
    Ig; Immunoglobulin domain
    smart00410
    Location:219 → 294
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  6. NM_001322105.2 → NP_001309034.1  sialic acid-binding Ig-like lectin 10 isoform 8 precursor

    Status: REVIEWED

    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS82384.1
    UniProtKB/TrEMBL
    B7ZL04, E9PL79
    Related
    ENSP00000431444.1, ENST00000525998.5
    Conserved Domains (3) summary
    cd00096
    Location:288 → 349
    Ig; Immunoglobulin domain
    smart00410
    Location:277 → 352
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  7. NM_033130.5 → NP_149121.2  sialic acid-binding Ig-like lectin 10 isoform 1 precursor

    See identical proteins and their annotated locations for NP_149121.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC008750
    Consensus CDS
    CCDS12832.1
    UniProtKB/Swiss-Prot
    A8K1I5, A8K3C7, C9JJ33, C9JM10, F8W917, Q3MIR5, Q6UXI8, Q96G54, Q96LC7, Q96LC8
    UniProtKB/TrEMBL
    B7ZL06
    Related
    ENSP00000345243.4, ENST00000339313.10
    Conserved Domains (4) summary
    cd00096
    Location:378 → 439
    Ig; Immunoglobulin domain
    smart00408
    Location:269 → 330
    IGc2; Immunoglobulin C-2 Type
    smart00410
    Location:367 → 442
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51410020..51417642 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047439605.1 → XP_047295561.1  sialic acid-binding Ig-like lectin 10 isoform X6

  2. XM_047439602.1 → XP_047295558.1  sialic acid-binding Ig-like lectin 10 isoform X3

  3. XM_047439601.1 → XP_047295557.1  sialic acid-binding Ig-like lectin 10 isoform X2

  4. XM_047439603.1 → XP_047295559.1  sialic acid-binding Ig-like lectin 10 isoform X4

  5. XM_047439600.1 → XP_047295556.1  sialic acid-binding Ig-like lectin 10 isoform X1

    Related
    ENST00000357375.4

  6. XM_005259367.5 → XP_005259424.1  sialic acid-binding Ig-like lectin 10 isoform X8

    UniProtKB/TrEMBL
    B7ZL06
    Conserved Domains (3) summary
    cd00096
    Location:230 → 291
    Ig; Immunoglobulin domain
    smart00410
    Location:219 → 294
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

  7. XM_047439604.1 → XP_047295560.1  sialic acid-binding Ig-like lectin 10 isoform X5

  8. XM_005259366.6 → XP_005259423.1  sialic acid-binding Ig-like lectin 10 isoform X7

    UniProtKB/TrEMBL
    B7ZL06
    Conserved Domains (3) summary
    cd00096
    Location:288 → 349
    Ig; Immunoglobulin domain
    smart00410
    Location:277 → 352
    IG_like; Immunoglobulin like
    cl11960
    Location:23 → 140
    Ig; Immunoglobulin domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54498651..54506273 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322496.1 → XP_054178471.1  sialic acid-binding Ig-like lectin 10 isoform X8

  2. XM_054322494.1 → XP_054178469.1  sialic acid-binding Ig-like lectin 10 isoform X5

  3. XM_054322495.1 → XP_054178470.1  sialic acid-binding Ig-like lectin 10 isoform X7

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001171160.1: Suppressed sequence

    Description
    NM_001171160.1: This RefSeq was permanently suppressed because currently there is support for the transcript but not for the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96LC7.3 GenPept UniProtKB/Swiss-Prot:Q96LC7

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