VNN1 vanin 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: VNN1provided by HGNC
Official Full Name: vanin 1provided by HGNC
Primary source: HGNC:HGNC:12705
See related: Ensembl:ENSG00000112299 MIM:603570; AllianceGenome:HGNC:12705
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: HDLCQ8; Tiff66
Summary: This gene encodes a member of the vanin family of proteins, which share extensive sequence similarity with each other, and also with biotinidase. The family includes secreted and membrane-associated proteins, a few of which have been reported to participate in hematopoietic cell trafficking. No biotinidase activity has been demonstrated for any of the vanin proteins, however, they possess pantetheinase activity, which may play a role in oxidative-stress response. This protein, like its mouse homolog, is likely a GPI-anchored cell surface molecule. The mouse protein is expressed by the perivascular thymic stromal cells and regulates migration of T-cell progenitors to the thymus. This gene lies in close proximity to, and in the same transcriptional orientation as, two other vanin genes on chromosome 6q23-q24. [provided by RefSeq, Feb 2009]
Expression: Biased expression in duodenum (RPKM 74.9), liver (RPKM 69.9) and 5 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q23.2

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (132680849..132714055, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (133875818..133909022, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (133001988..133035194, complement)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.
Title: Urinary vanin-1 for predicting acute pyelonephritis in young children with urinary tract infection: a pilot study.
Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role of Vanin-1 in Chemotherapy.
Title: Near-Infrared Fluorescent Probe for Imaging and Evaluating the Role of Vanin-1 in Chemotherapy.
Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1-mediated ROS release to inhibit NLRP3 activation.
Title: Pancreatic ductal deletion of S100A9 alleviates acute pancreatitis by targeting VNN1-mediated ROS release to inhibit NLRP3 activation.
This review discusses the role of vanin 1 in the liver, kidney, intestine, and lung under physiological as well as pathophysiological conditions. [review]
Title: Vanin 1: Its Physiological Function and Role in Diseases.
Urinary vanin-1 is a useful biomarker to detect and monitor the clinical course of obstructive nephropathy.
Title: A Novel Biomarker for Acute Kidney Injury, Vanin-1, for Obstructive Nephropathy: A Prospective Cohort Pilot Study.
findings suggest that the metabolic pathway catalyzed by VNN1 pantetheinase plays a suppressive role in IAV infection in the respiratory tract, especially in severe conditions under hypercytokinemia
Title: Metabolic pathway catalyzed by Vanin-1 pantetheinase plays a suppressive role in influenza virus replication in human alveolar epithelial A549 cells.
Data show that G protein-coupled receptor, family C, group 5, member A protein (GPRC5A) regulates oxidative stress through vanin 1 protein (VNN1).
Title: Elevation of GPRC5A expression in colorectal cancer promotes tumor progression through VNN-1 induced oxidative stress.
These data suggest that urinary vanin-1 is an early predictive biomarker for decline in eGFR in patients with urothelial carcinoma after dosing of cisplatin
Title: Early prediction of cisplatin-induced nephrotoxicity by urinary vanin-1 in patients with urothelial carcinoma.
serum pantetheinas, encoded by the VNN1 gene, level regulates erythrocyte life span and modulates the risk of developing complicated malaria.
Title: Serum pantetheinase/vanin levels regulate erythrocyte homeostasis and severity of malaria.
VNN1 contributes to corticosteroid responsiveness, and changes in VNN1 nasal epithelial mRNA expression and VNN1 promoter methylation might be clinically useful biomarkers of treatment response in asthmatic children.
Title: Vanin-1 expression and methylation discriminate pediatric asthma corticosteroid treatment response.

Submit: New GeneRIF Correction See all GeneRIFs (30)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

VNN1 (e-PCR)
- UniSTS:514076

NoName (e-PCR)
- UniSTS:481201

Clone Names

MGC116930, MGC116931, MGC116932, MGC116933

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables pantetheine hydrolase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pantetheine hydrolase activity	IDA Inferred from Direct Assay more info	PubMed
enables pantetheine hydrolase activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in acute inflammatory response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in cell-cell adhesion	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in chronic inflammatory response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in coenzyme A catabolic process	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in innate immune response	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in pantothenate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in pantothenate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in pantothenate metabolic process	TAS Traceable Author Statement more info
involved_in positive regulation of T cell differentiation in thymus	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in response to oxidative stress	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in azurophil granule membrane	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info
located_in membrane	TAS Traceable Author Statement more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: pantetheinase

Names: pantetheine hydrolase; vannin 1; vascular non-inflammatory molecule 1

NP_004657.2

EC 3.5.1.92

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.