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ASAP2 ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 [ Homo sapiens (human) ]

Gene ID: 8853, updated on 5-Mar-2024

Summary

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Official Symbol
ASAP2provided by HGNC
Official Full Name
ArfGAP with SH3 domain, ankyrin repeat and PH domain 2provided by HGNC
Primary source
HGNC:HGNC:2721
See related
Ensembl:ENSG00000151693 MIM:603817; AllianceGenome:HGNC:2721
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAP; PAG3; AMAP2; DDEF2; SHAG1; CENTB3; Pap-alpha
Summary
This gene encodes a multidomain protein containing an N-terminal alpha-helical region with a coiled-coil motif, followed by a pleckstrin homology (PH) domain, an Arf-GAP domain, an ankyrin homology region, a proline-rich region, and a C-terminal Src homology 3 (SH3) domain. The protein localizes in the Golgi apparatus and at the plasma membrane, where it colocalizes with protein tyrosine kinase 2-beta (PYK2). The encoded protein forms a stable complex with PYK2 in vivo. This interaction appears to be mediated by binding of its SH3 domain to the C-terminal proline-rich domain of PYK2. The encoded protein is tyrosine phosphorylated by activated PYK2. It has catalytic activity for class I and II ArfGAPs in vitro, and can bind the class III Arf ARF6 without immediate GAP activity. The encoded protein is believed to function as an ARF GAP that controls ARF-mediated vesicle budding when recruited to Golgi membranes. In addition, it functions as a substrate and downstream target for PYK2 and SRC, a pathway that may be involved in the regulation of vesicular transport. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]
Expression
Broad expression in testis (RPKM 24.6), kidney (RPKM 11.9) and 21 other tissues See more
Orthologs
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Genomic context

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Location:
2p25.1; 2p24
Exon count:
33
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (9206812..9405678)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (9230598..9430981)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (9346941..9545807)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105373416 Neighboring gene uncharacterized LOC105373415 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:9269636-9269796 Neighboring gene uncharacterized LOC105373417 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9279832-9280332 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9282151-9283048 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15275 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9289685-9290604 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:9319676-9320875 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:9346090-9347022 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:9347023-9347953 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr2:9357948-9358822 Neighboring gene Sharpr-MPRA regulatory region 15524 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9371198-9371754 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9371755-9372309 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:9374524-9375723 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr2:9427423-9428622 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:9439781-9440280 Neighboring gene eukaryotic translation initiation factor 1 pseudogene 7 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr2:9495983-9497182 Neighboring gene Sharpr-MPRA regulatory region 10317 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9513595-9514143 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9514144-9514692 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9518857-9519441 Neighboring gene uncharacterized LOC124907730 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9532979-9533616 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9533617-9534254 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9540673-9541236 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9562108-9562966 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15276 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15277 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15278 Neighboring gene integrin subunit beta 1 binding protein 1 Neighboring gene cleavage and polyadenylation specific factor 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:9614491-9615258 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:9615739-9616299 Neighboring gene isoamyl acetate hydrolyzing esterase 1 (putative) Neighboring gene ADAM metallopeptidase domain 17

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer. Fujii A, et al. Cancer Sci, 2021 Apr. PMID 33605496, Free PMC Article
  2. The ASAP2 gene is a primary target of 1,25-dihydroxyvitamin D3 in human monocytes and macrophages. Seuter S, et al. J Steroid Biochem Mol Biol, 2014 Oct. PMID 23999061
  3. A novel mode of action of an ArfGAP, AMAP2/PAG3/Papa lpha, in Arf6 function. Hashimoto S, et al. J Biol Chem, 2004 Sep 3. PMID 15231847
  4. PAG3/Papalpha/KIAA0400, a GTPase-activating protein for ADP-ribosylation factor (ARF), regulates ARF6 in Fcgamma receptor-mediated phagocytosis of macrophages. Uchida H, et al. J Exp Med, 2001 Apr 16. PMID 11304556, Free PMC Article
  5. Regulation of Bin1 SH3 domain binding by phosphoinositides. Kojima C, et al. EMBO J, 2004 Nov 10. PMID 15483625, Free PMC Article

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer.
    Title: The novel driver gene ASAP2 is a potential druggable target in pancreatic cancer.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Replication of top markers of a genome-wide association study in multiple sclerosis in Spain.
  3. regulates multiple cytokine and growth factor-activated signaling pathways by acting as a recruitment factor for adapter proteins
    Title: A novel mode of action of an ArfGAP, AMAP2/PAG3/Papa lpha, in Arf6 function.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ42910, KIAA0400

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
  

General protein information

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Preferred Names
arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2
Names
PYK2 C terminus-associated protein
centaurin, beta 3
development and differentiation-enhancing factor 2
paxillin-associated protein with ARF GAP activity 3
pyk2 C-terminus-associated protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001135191.2 → NP_001128663.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform b

    See identical proteins and their annotated locations for NP_001128663.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting protein (isoform b) is lacking a 45-aa portion of the proline-rich region, compared to isoform a.
    Source sequence(s)
    AA918883, AB007860, AC079782, BC063308
    Consensus CDS
    CCDS46224.1
    UniProtKB/Swiss-Prot
    O43150
    Related
    ENSP00000316404.4, ENST00000315273.4
    Conserved Domains (6) summary
    cd07642
    Location:34 → 248
    BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
    cd11966
    Location:903 → 958
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd13251
    Location:297 → 403
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    sd00045
    Location:586 → 618
    ANK; ANK repeat [structural motif]
    cd08849
    Location:419 → 541
    ArfGap_ASAP2; ArfGAP domain of ASAP2 (ArfGAP2 with SH3 domain, ANK repeat and PH domain-containing protein 2)
    pfam12796
    Location:589 → 673
    Ank_2; Ankyrin repeats (3 copies)

  2. NM_003887.3 → NP_003878.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform a

    See identical proteins and their annotated locations for NP_003878.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    AA918883, AB007860, AC079782
    Consensus CDS
    CCDS1661.1
    UniProtKB/Swiss-Prot
    D6W4Y8, O43150
    Related
    ENSP00000281419.3, ENST00000281419.8
    Conserved Domains (8) summary
    cd07642
    Location:34 → 248
    BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
    cd11966
    Location:948 → 1003
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd00204
    Location:579 → 673
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:297 → 403
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:306 → 393
    PH; PH domain
    pfam01412
    Location:421 → 538
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:607 → 661
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:586 → 618
    ANK; ANK repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    9206812..9405678
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510403.4 → XP_011508705.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1

    Conserved Domains (8) summary
    cd11966
    Location:962 → 1017
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd00204
    Location:593 → 687
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:311 → 417
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:320 → 407
    PH; PH domain
    pfam01412
    Location:435 → 552
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:621 → 675
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:600 → 632
    ANK; ANK repeat [structural motif]
    cl12013
    Location:34 → 259
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  2. XM_011510407.3 → XP_011508709.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X8

    Conserved Domains (8) summary
    cd11966
    Location:917 → 972
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd00204
    Location:593 → 687
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:311 → 417
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:320 → 407
    PH; PH domain
    pfam01412
    Location:435 → 552
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:621 → 675
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:600 → 632
    ANK; ANK repeat [structural motif]
    cl12013
    Location:34 → 259
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  3. XM_011510404.3 → XP_011508706.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2

    Conserved Domains (8) summary
    cd11966
    Location:959 → 1014
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd00204
    Location:590 → 684
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:308 → 414
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:317 → 404
    PH; PH domain
    pfam01412
    Location:432 → 549
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:618 → 672
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:597 → 629
    ANK; ANK repeat [structural motif]
    cl12013
    Location:34 → 259
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  4. XM_047446201.1 → XP_047302157.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X9

  5. XM_011510405.4 → XP_011508707.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X4

    Conserved Domains (8) summary
    cd11966
    Location:937 → 992
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd00204
    Location:568 → 662
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:286 → 392
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:295 → 382
    PH; PH domain
    pfam01412
    Location:410 → 527
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:596 → 650
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:575 → 607
    ANK; ANK repeat [structural motif]
    cl12013
    Location:34 → 234
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  6. XM_047446199.1 → XP_047302155.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X5

  7. XM_047446208.1 → XP_047302164.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X15

  8. XM_011510406.3 → XP_011508708.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X7

    Conserved Domains (8) summary
    cd11966
    Location:920 → 975
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd00204
    Location:551 → 645
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:269 → 375
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:278 → 365
    PH; PH domain
    pfam01412
    Location:393 → 510
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:579 → 633
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:558 → 590
    ANK; ANK repeat [structural motif]
    cl12013
    Location:11 → 217
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  9. XM_006711898.2 → XP_006711961.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3

    Conserved Domains (8) summary
    cd07642
    Location:34 → 248
    BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
    cd11966
    Location:951 → 1006
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd00204
    Location:582 → 676
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:300 → 406
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:309 → 396
    PH; PH domain
    pfam01412
    Location:424 → 541
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:610 → 664
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:589 → 621
    ANK; ANK repeat [structural motif]

  10. XM_006711902.2 → XP_006711965.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X12

    Conserved Domains (8) summary
    cd07642
    Location:34 → 248
    BAR_ASAP2; The Bin/Amphiphysin/Rvs (BAR) domain of ArfGAP with SH3 domain, ANK repeat and PH domain containing protein 2
    cd11966
    Location:906 → 961
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd00204
    Location:582 → 676
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:300 → 406
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:309 → 396
    PH; PH domain
    pfam01412
    Location:424 → 541
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:610 → 664
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:589 → 621
    ANK; ANK repeat [structural motif]

  11. XM_047446200.1 → XP_047302156.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X6

  12. XM_047446223.1 → XP_047302179.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X17

  13. XM_011510408.4 → XP_011508710.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X14

    Conserved Domains (7) summary
    cd00204
    Location:593 → 687
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:311 → 417
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:320 → 407
    PH; PH domain
    pfam01412
    Location:435 → 552
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:621 → 675
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:600 → 632
    ANK; ANK repeat [structural motif]
    cl12013
    Location:34 → 259
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  14. XM_047446219.1 → XP_047302175.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X16

  15. XM_047446205.1 → XP_047302161.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X13

  16. XM_047446228.1 → XP_047302184.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X18

  17. XM_006711901.4 → XP_006711964.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X10

    Conserved Domains (8) summary
    cd11966
    Location:912 → 967
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd00204
    Location:543 → 637
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:261 → 367
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:270 → 357
    PH; PH domain
    pfam01412
    Location:385 → 502
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:571 → 625
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:550 → 582
    ANK; ANK repeat [structural motif]
    cl12013
    Location:3 → 209
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  18. XM_047446202.1 → XP_047302158.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X11

  19. XM_011510409.1 → XP_011508711.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X19

    Conserved Domains (8) summary
    cd11966
    Location:833 → 888
    SH3_ASAP2; Src homology 3 domain of ArfGAP with SH3 domain, ankyrin repeat and PH domain containing protein 2
    cd00204
    Location:464 → 558
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    cd13251
    Location:182 → 288
    PH_ASAP; ArfGAP with SH3 domain, ankyrin repeat and PH domain Pleckstrin homology (PH) domain
    pfam00169
    Location:191 → 278
    PH; PH domain
    pfam01412
    Location:306 → 423
    ArfGap; Putative GTPase activating protein for Arf
    pfam13857
    Location:492 → 546
    Ank_5; Ankyrin repeats (many copies)
    sd00045
    Location:471 → 503
    ANK; ANK repeat [structural motif]
    cl12013
    Location:1 → 130
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature

  20. XM_047446229.1 → XP_047302185.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X20

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    9230598..9430981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344382.1 → XP_054200357.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X7

  2. XM_054344378.1 → XP_054200353.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X3

  3. XM_054344387.1 → XP_054200362.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X12

  4. XM_054344381.1 → XP_054200356.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X6

  5. XM_054344391.1 → XP_054200366.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X17

  6. XM_054344390.1 → XP_054200365.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X16

  7. XM_054344384.1 → XP_054200359.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X9

  8. XM_054344388.1 → XP_054200363.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X14

  9. XM_054344379.1 → XP_054200354.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X4

  10. XM_054344376.1 → XP_054200351.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X1

  11. XM_054344383.1 → XP_054200358.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X8

  12. XM_054344380.1 → XP_054200355.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X5

  13. XM_054344377.1 → XP_054200352.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X2

  14. XM_054344389.1 → XP_054200364.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X15

  15. XM_054344392.1 → XP_054200367.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X18

  16. XM_054344385.1 → XP_054200360.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X10

  17. XM_054344386.1 → XP_054200361.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X11

  18. XM_054344393.1 → XP_054200368.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X19

  19. XM_054344394.1 → XP_054200369.1  arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 isoform X20

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43150.3 GenPept UniProtKB/Swiss-Prot:O43150

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