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SOCS2 suppressor of cytokine signaling 2 [ Homo sapiens (human) ]

Gene ID: 8835, updated on 10-Dec-2024

Summary

Official Symbol
SOCS2provided by HGNC
Official Full Name
suppressor of cytokine signaling 2provided by HGNC
Primary source
HGNC:HGNC:19382
See related
Ensembl:ENSG00000120833 MIM:605117; AllianceGenome:HGNC:19382
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CIS2; SSI2; Cish2; SSI-2; SOCS-2; STATI2
Summary
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Expression
Broad expression in endometrium (RPKM 13.5), prostate (RPKM 10.5) and 22 other tissues See more
Orthologs
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Genomic context

See SOCS2 in Genome Data Viewer
Location:
12q22
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (93569969..93626236)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (93551422..93607676)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (93963745..93970521)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene mitochondrial ribosomal protein L42 Neighboring gene RNA, 7SL, cytoplasmic 737, pseudogene Neighboring gene uncharacterized LOC124902985 Neighboring gene MPRA-validated peak1894 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4711 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4712 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4713 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4714 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 4715 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6771 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:93975910-93976410 Neighboring gene SOCS2 antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:93976411-93976911 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:93977698-93978644 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:93978645-93979590 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:93984897-93985456 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr12:94018330-94019529 Neighboring gene phosphoglycerate mutase 1 (brain) pseudogene Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:94070392-94071207 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:94071208-94072022 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr12:94072839-94073653 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr12:94092983-94093855 Neighboring gene CASP2 and RIPK1 domain containing adaptor with death domain Neighboring gene CRADD antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide analysis of hepatic lipid content in extreme obesity.
EBI GWAS Catalog
Genome-wide association analysis identifies 20 loci that influence adult height.
EBI GWAS Catalog
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.
EBI GWAS Catalog
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog
Hundreds of variants clustered in genomic loci and biological pathways affect human height.
EBI GWAS Catalog
Many sequence variants affecting diversity of adult human height.
EBI GWAS Catalog
Meta-analysis of genome-wide association studies of adult height in East Asians identifies 17 novel loci.
EBI GWAS Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat upregulates the expression of suppressor of cytokine signaling 2 (SOCS2) in human primary T cells PubMed
tat HIV-1 Tat impairs the IFNgamma-receptor signaling pathway in primary human monocytes at the level of STAT1 activation via Tat-dependent induction of suppressor of cytokine signaling-2 (SOCS-2) activity PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

General gene information

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cell surface receptor signaling pathway via JAK-STAT  
involved_in cellular response to hormone stimulus PubMed 
involved_in cytokine-mediated signaling pathway  
involved_in growth hormone receptor signaling pathway PubMed 
involved_in intracellular signal transduction  
involved_in lactation  
involved_in mammary gland alveolus development  
involved_in negative regulation of apoptotic process PubMed 
involved_in negative regulation of growth hormone receptor signaling pathway PubMed 
involved_in negative regulation of multicellular organism growth  
involved_in negative regulation of receptor signaling pathway via JAK-STAT  
involved_in negative regulation of signal transduction PubMed 
involved_in positive regulation of neuron differentiation  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process PubMed 
involved_in protein ubiquitination  
involved_in regulation of cell growth PubMed 
involved_in regulation of signal transduction PubMed 
involved_in response to estradiol PubMed 
Component Evidence Code Pubs
part_of Cul5-RING ubiquitin ligase complex PubMed 
is_active_in cytoplasm PubMed 
located_in cytoplasm PubMed 
located_in cytosol  

General protein information

Preferred Names
suppressor of cytokine signaling 2
Names
CIS-2
STAT-induced STAT inhibitor 2
cytokine-inducible SH2 protein 2

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001270467.2NP_001257396.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_001257396.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.
    Source sequence(s)
    AC012085, AI129818, AK313165, BC010399, BJ996504, CD699665, DA709082
    Consensus CDS
    CCDS9047.1
    UniProtKB/Swiss-Prot
    A8K3D1, O14508, O14542, O95102, Q9UKS5
    UniProtKB/TrEMBL
    B5BU82
    Related
    ENSP00000448815.1, ENST00000549206.5
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  2. NM_001270468.2NP_001257397.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_001257397.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.
    Source sequence(s)
    AI129818, AK313165, BC010399, BJ996504, CD699665, DA490057
    Consensus CDS
    CCDS9047.1
    UniProtKB/Swiss-Prot
    A8K3D1, O14508, O14542, O95102, Q9UKS5
    UniProtKB/TrEMBL
    B5BU82
    Related
    ENSP00000442898.2, ENST00000536696.6
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  3. NM_001270469.2NP_001257398.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_001257398.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.
    Source sequence(s)
    AI129818, AK313165, BC010399, BJ996504, CD699665, DB054162
    Consensus CDS
    CCDS9047.1
    UniProtKB/Swiss-Prot
    A8K3D1, O14508, O14542, O95102, Q9UKS5
    UniProtKB/TrEMBL
    B5BU82
    Related
    ENSP00000447161.1, ENST00000549122.5
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  4. NM_001270470.1NP_001257399.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_001257399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) represents the longest transcript. Variants 1-6 encode the same protein.
    Source sequence(s)
    AI129818, AK313165, BC010399, BJ996504, CD699665, DB054162, DB481261
    Consensus CDS
    CCDS9047.1
    UniProtKB/Swiss-Prot
    A8K3D1, O14508, O14542, O95102, Q9UKS5
    UniProtKB/TrEMBL
    B5BU82
    Related
    ENSP00000481249.1, ENST00000622746.4
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  5. NM_001270471.2NP_001257400.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_001257400.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.
    Source sequence(s)
    AI129818, AK313165, BC010399, BJ996504, CD699665, DC300183
    Consensus CDS
    CCDS9047.1
    UniProtKB/Swiss-Prot
    A8K3D1, O14508, O14542, O95102, Q9UKS5
    UniProtKB/TrEMBL
    B5BU82
    Related
    ENSP00000449227.1, ENST00000551556.2
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  6. NM_003877.5NP_003868.1  suppressor of cytokine signaling 2

    See identical proteins and their annotated locations for NP_003868.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 5. Variants 1-6 encode the same protein.
    Source sequence(s)
    AI129818, AK313165, AL522912, BC010399, BJ996504, CD699665
    Consensus CDS
    CCDS9047.1
    UniProtKB/Swiss-Prot
    A8K3D1, O14508, O14542, O95102, Q9UKS5
    UniProtKB/TrEMBL
    B5BU82
    Related
    ENSP00000339428.2, ENST00000340600.6
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

    Range
    93569969..93626236
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017020147.2XP_016875636.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  2. XM_017020152.2XP_016875641.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  3. XM_047429808.1XP_047285764.1  suppressor of cytokine signaling 2 isoform X6

    UniProtKB/Swiss-Prot
    A8K3D1, O14508, O14542, O95102, Q9UKS5
    UniProtKB/TrEMBL
    B5BU82
  4. XM_017020148.3XP_016875637.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  5. XM_017020151.2XP_016875640.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  6. XM_047429807.1XP_047285763.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  7. XM_017020149.2XP_016875638.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  8. XM_011538935.2XP_011537237.1  suppressor of cytokine signaling 2 isoform X4

    UniProtKB/TrEMBL
    B5BU82
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158198
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  9. XM_011538936.2XP_011537238.1  suppressor of cytokine signaling 2 isoform X5

    UniProtKB/TrEMBL
    B5BU82
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158197
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  10. XM_011538929.2XP_011537231.1  suppressor of cytokine signaling 2 isoform X3

    See identical proteins and their annotated locations for XP_011537231.1

    UniProtKB/TrEMBL
    B5BU82
    Conserved Domains (2) summary
    cd10383
    Location:40142
    SH2_SOCS2; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
    cd03736
    Location:158197
    SOCS_SOCS2; SOCS (suppressors of cytokine signaling) box of SOCS2-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS2 has recently been shown to regulate ...
  11. XM_017020155.3XP_016875644.1  suppressor of cytokine signaling 2 isoform X2

    UniProtKB/TrEMBL
    B5BU82

RNA

  1. XR_944810.2 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060936.1 Alternate T2T-CHM13v2.0

    Range
    93551422..93607676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054373709.1XP_054229684.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  2. XM_054373713.1XP_054229688.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  3. XM_054373710.1XP_054229685.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  4. XM_054373712.1XP_054229687.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  5. XM_054373711.1XP_054229686.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82
  6. XM_054373716.1XP_054229691.1  suppressor of cytokine signaling 2 isoform X4

    UniProtKB/TrEMBL
    B5BU82
  7. XM_054373717.1XP_054229692.1  suppressor of cytokine signaling 2 isoform X5

    UniProtKB/TrEMBL
    B5BU82
  8. XM_054373715.1XP_054229690.1  suppressor of cytokine signaling 2 isoform X3

    UniProtKB/TrEMBL
    B5BU82
  9. XM_054373714.1XP_054229689.1  suppressor of cytokine signaling 2 isoform X2

    UniProtKB/TrEMBL
    B5BU82
  10. XM_054373708.1XP_054229683.1  suppressor of cytokine signaling 2 isoform X1

    UniProtKB/TrEMBL
    B5BU82

RNA

  1. XR_008488706.1 RNA Sequence

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