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EIF3A eukaryotic translation initiation factor 3 subunit A [ Homo sapiens (human) ]

Gene ID: 8661, updated on 11-Apr-2024

Summary

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Official Symbol
EIF3Aprovided by HGNC
Official Full Name
eukaryotic translation initiation factor 3 subunit Aprovided by HGNC
Primary source
HGNC:HGNC:3271
See related
Ensembl:ENSG00000107581 MIM:602039; AllianceGenome:HGNC:3271
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIF3; P167; p180; p185; TIF32; EIF3S10; eIF3-p170; eIF3-theta
Summary
Enables RNA binding activity. Contributes to translation initiation factor activity. Involved in IRES-dependent viral translational initiation; formation of cytoplasmic translation initiation complex; and viral translational termination-reinitiation. Located in cytosol; nucleolus; and nucleoplasm. Part of eukaryotic translation initiation factor 3 complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 51.4), fat (RPKM 50.1) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
10q26.11
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (119033670..119080817, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (119929080..119976262, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (120793182..120840329, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 3036 Neighboring gene ribosomal protein L17 pseudogene 36 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:120654814-120655422 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120718457-120719187 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120719188-120719917 Neighboring gene lactate dehydrogenase A pseudogene 5 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120781819-120782461 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120782462-120783104 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120784290-120784863 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120788503-120789003 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2866 Neighboring gene small nucleolar RNA SNORA19 Neighboring gene nanos C2HC-type zinc finger 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120826117-120826618 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2867 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:120840059-120840821 Neighboring gene small nucleolar RNA, H/ACA box 19 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120852323-120852823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2868 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120865335-120865834 Neighboring gene Sharpr-MPRA regulatory region 2644 Neighboring gene DENN domain containing 10 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:120901959-120902460 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:120924677-120924863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2869 Neighboring gene sideroflexin 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content. Duan H, et al. EMBO J, 2023 Jun 15. PMID 37155573, Free PMC Article
  2. eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer. Chen YX, et al. Pharmacol Res, 2021 Dec. PMID 34648968
  3. The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair. Chen J, et al. Biochem Pharmacol, 2021 Aug. PMID 34022189
  4. Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells. Zheng X, et al. Genes Genomics, 2021 Apr. PMID 33595813
  5. Circular RNA screening from EIF3a in lung cancer. Huang MS, et al. Cancer Med, 2019 Aug. PMID 31197975, Free PMC Article

See all (272) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
    Title: The Helix-Loop-Helix motif of human EIF3A regulates translation of proliferative cellular mRNAs.
  2. eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content.
    Title: eIF3 mRNA selectivity profiling reveals eIF3k as a cancer-relevant regulator of ribosome content.
  3. Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation.
    Title: Translation initiation factor eIF3a regulates glucose metabolism and cell proliferation via promoting small GTPase Rheb synthesis and AMPK activation.
  4. YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.
    Title: YTHDF3 Facilitates eIF2AK2 and eIF3A Recruitment on mRNAs to Regulate Translational Processes in Oxaliplatin-Resistant Colorectal Cancer.
  5. eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage.
    Title: eIF3a regulation of mTOR signaling and translational control via HuR in cellular response to DNA damage.
  6. eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
    Title: eIF3a R803K mutation mediates chemotherapy resistance by inducing cellular senescence in small cell lung cancer.
  7. Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells.
    Title: Knockdown of eIF3a attenuated cell growth in K1 human thyroid cancer cells.
  8. The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
    Title: The effect of eIF3a on anthracycline-based chemotherapy resistance by regulating DSB DNA repair.
  9. LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway.
    Title: LncRNA H19 promotes keloid formation through targeting the miR-769-5p/EIF3A pathway.
  10. MicroRNA8755p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
    Title: MicroRNA‑875‑5p inhibits tumor growth and metastasis of hepatocellular carcinoma by targeting eukaryotic translation initiation factor 3 subunit a.
Submit: New GeneRIF Correction See all GeneRIFs (59)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Gag-Pol gag-pol Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Nef nef Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
Pr55(Gag) gag Tandem affinity purification and mass spectrometry analysis identify subunit A of eukaryotic translation initiation factor 3 (EIF3A), HIV-1 Gag, Gag/Pol, gp120, and Nef incorporated into staufen1 RNP complexes isolated from HIV-1-expressing cells PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with eukaryotic translation initiation factor 3, subunit A (EIF3A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA0139

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables structural molecule activity NAS
Non-traceable Author Statement
more info
 PubMed 
contributes_to translation initiation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
contributes_to translation initiation factor activity IC
Inferred by Curator
more info
 PubMed 
contributes_to translation initiation factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in IRES-dependent viral translational initiation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formation of cytoplasmic translation initiation complex IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in formation of cytoplasmic translation initiation complex IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in formation of cytoplasmic translation initiation complex NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of ERK1 and ERK2 cascade IEA
Inferred from Electronic Annotation
more info
  
involved_in translation reinitiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translational initiation IC
Inferred by Curator
more info
 PubMed 
involved_in viral translational termination-reinitiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
part_of eukaryotic 43S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic 48S preinitiation complex IEA
Inferred from Electronic Annotation
more info
  
part_of eukaryotic translation initiation factor 3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of eukaryotic translation initiation factor 3 complex, eIF3e IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of eukaryotic translation initiation factor 3 complex, eIF3m IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane HDA PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
  
part_of multi-eIF complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in postsynaptic density IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
eukaryotic translation initiation factor 3 subunit A
Names
EIF3, p180 subunit
centrosomin homolog
cytoplasmic protein p167
eIF-3-theta
eIF3 p167
eIF3 p180
eIF3 p185
eukaryotic translation initiation factor 3 subunit 10
eukaryotic translation initiation factor 3, subunit 10 (theta, 150/170kD)
eukaryotic translation initiation factor 3, subunit 10 (theta, 170kD)
eukaryotic translation initiation factor 3, subunit 10 theta, 150/170kDa
eukaryotic translation initiation factor 3, subunit 10, 170kD

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003750.4 → NP_003741.1  eukaryotic translation initiation factor 3 subunit A

    See identical proteins and their annotated locations for NP_003741.1

    Status: VALIDATED

    Source sequence(s)
    AL157788, AL355598
    Consensus CDS
    CCDS7608.1
    UniProtKB/Swiss-Prot
    B1AMV5, B4DYS1, F5H335, O00653, Q14152, Q15778
    UniProtKB/TrEMBL
    Q24JU4
    Related
    ENSP00000358140.3, ENST00000369144.8
    Conserved Domains (5) summary
    smart00088
    Location:426 → 498
    PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
    COG1196
    Location:517 → 791
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    PRK12678
    Location:910 → 1126
    PRK12678; transcription termination factor Rho; Provisional
    PRK14086
    Location:1127 → 1253
    dnaA; chromosomal replication initiator protein DnaA
    TIGR01642
    Location:1199 → 1258
    U2AF_lg; U2 snRNP auxilliary factor, large subunit, splicing factor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    119033670..119080817 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    119929080..119976262 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q14152.1 GenPept UniProtKB/Swiss-Prot:Q14152

Gene LinkOut

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