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Klf15 KLF transcription factor 15 [ Rattus norvegicus (Norway rat) ]

Gene ID: 85497, updated on 13-Apr-2024

Summary

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Official Symbol
Klf15provided by RGD
Official Full Name
KLF transcription factor 15provided by RGD
Primary source
RGD:70918
See related
Ensembl:ENSRNOG00000017808 AllianceGenome:RGD:70918
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to peptide. Predicted to be located in nuclear speck. Orthologous to human KLF15 (Kruppel like factor 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 109.6), Liver (RPKM 91.5) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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See Klf15 in Genome Data Viewer
Location:
4q34
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 4 NC_086022.1 (124522652..124535613)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 4 NC_051339.1 (122965718..122978403)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 4 NC_005103.4 (122364688..122377690)

Chromosome 4 - NC_086022.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134486812 Neighboring gene ZXD family zinc finger C Neighboring gene cilia and flagella associated protein 100 Neighboring gene uncharacterized LOC134486813 Neighboring gene aldehyde dehydrogenase 1 family, member L1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Krϋppel-like factor 15 suppresses renal glomerular mesangial cell proliferation via enhancing P53 SUMO1 conjugation. Wu L, et al. J Cell Mol Med, 2021 Jun. PMID 33949114, Free PMC Article
  2. Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15. Patel SK, et al. BMC Nephrol, 2018 Jul 3. PMID 29970016, Free PMC Article
  3. Resveratrol-Mediated Expression of KLF15 in the Ischemic Myocardium is Associated with an Improved Cardiac Phenotype. Rogers RG, et al. Cardiovasc Drugs Ther, 2017 Feb. PMID 28064408
  4. [Impacts and mechanisms of kruppel like factor 15 in pressure overload induced cardiac remodeling and angiogenesis in rats]. Yu Y, et al. Zhonghua Xin Xue Guan Bing Za Zhi, 2015 Feb. PMID 25907490
  5. KLF15 is an essential negative regulatory factor for the cardiac remodeling response to pressure overload. Yu Y, et al. Cardiology, 2015. PMID 25633973

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. [KLF15/mTOR related proteins involved in effect of aerobic interval training on improving skeletal muscle lesions in rats with type 2 diabetes].
    Title: [KLF15/mTOR related proteins involved in effect of aerobic interval training on improving skeletal muscle lesions in rats with type 2 diabetes].
  2. Krupsilonppel-like factor 15 suppresses renal glomerular mesangial cell proliferation via enhancing P53 SUMO1 conjugation.
    Title: Krϋppel-like factor 15 suppresses renal glomerular mesangial cell proliferation via enhancing P53 SUMO1 conjugation.
  3. MiR-137-3p exacerbates the ischemia-reperfusion injured cardiomyocyte apoptosis by targeting KLF15.
    Title: MiR-137-3p exacerbates the ischemia-reperfusion injured cardiomyocyte apoptosis by targeting KLF15.
  4. Loss of cardiac KLF15 in chronic kidney disease induced left ventricular hypertrophy, is associated with trophic and fibrotic signaling.
    Title: Left ventricular hypertrophy in experimental chronic kidney disease is associated with reduced expression of cardiac Kruppel-like factor 15.
  5. Angiotensin II stimulation of transforming growth factor beta expression in the myocytes activated p38alpha kinase via TAK1 kinase, inhibiting KLF15 expression.
    Title: Estrogen receptor beta maintains expression of KLF15 to prevent cardiac myocyte hypertrophy in female rodents.
  6. Ang II down-regulates KLF15 expression via the AT1 receptor, and KLF15 is likely to inhibit Ang II-induced CTGF expression by repressing the recruitment of the co-activator P/CAF to the CTGF promoter.
    Title: KLF 15 Works as an Early Anti-Fibrotic Transcriptional Regulator in Ang II-Induced Renal Fibrosis via Down-Regulation of CTGF Expression.
  7. Overexpression of KLF15 can partially rescue aortic remodeling and aortic dissection formation in animal models by inhibiting CTGF expression.
    Title: KLF15 Overexpression Protects β-Aminopropionitrile-Induced Aortic Rupture in Rodent Model via Inhibiting Connective Tissue Growth Factor.
  8. Resveratrol treatment induces KLF15 expression, which may, in part, explain its therapeutic efficacy to improve the cardiac phenotype following ischemic injury.
    Title: Resveratrol-Mediated Expression of KLF15 in the Ischemic Myocardium is Associated with an Improved Cardiac Phenotype.
  9. KLF15 is repressed after pressure overload and induces fibrotic changes in the heart.
    Title: KLF15 is an essential negative regulatory factor for the cardiac remodeling response to pressure overload.
  10. upregulation of KLF15 expression in myocardial fibroblasts might promote vascular generation, alleviate the myocardial interstitial fibrosis and improve cardiac function in this pressure overload rat model
    Title: [Impacts and mechanisms of kruppel like factor 15 in pressure overload induced cardiac remodeling and angiogenesis in rats].
Submit: New GeneRIF Correction See all GeneRIFs (17)

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC108619

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle hypertrophy in response to stress ISO
Inferred from Sequence Orthology
more info
  
involved_in cellular response to peptide IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within glial cell differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within intracellular glucose homeostasis ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of peptidyl-lysine acetylation ISO
Inferred from Sequence Orthology
more info
  
involved_in podocyte differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within positive regulation of glucose import ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of gene expression ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to insulin ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear speck IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear speck ISO
Inferred from Sequence Orthology
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
Krueppel-like factor 15
Names
Kruppel-like factor 15

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053536.2 → NP_445988.2  Krueppel-like factor 15

    Status: PROVISIONAL

    Source sequence(s)
    JAXUCZ010000004
    UniProtKB/TrEMBL
    A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
    Related
    ENSRNOP00000024011.2, ENSRNOT00000024011.6
    Conserved Domains (3) summary
    COG5189
    Location:318 → 400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:322 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd21580
    Location:3 → 320
    KLF15_N; N-terminal domain of Kruppel-like factor 15

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086022.1 Reference GRCr8

    Range
    124522652..124535613
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039108490.2 → XP_038964418.1  Krueppel-like factor 15 isoform X1

    UniProtKB/TrEMBL
    A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
    Conserved Domains (3) summary
    COG5189
    Location:318 → 400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:322 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd21580
    Location:3 → 320
    KLF15_N; N-terminal domain of Kruppel-like factor 15

  2. XM_063286783.1 → XP_063142853.1  Krueppel-like factor 15 isoform X1

    UniProtKB/TrEMBL
    A6IB85, B2DBE3, Q5FVT6

  3. XM_017592934.3 → XP_017448423.1  Krueppel-like factor 15 isoform X1

    UniProtKB/TrEMBL
    A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
    Conserved Domains (3) summary
    COG5189
    Location:318 → 400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:322 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd21580
    Location:3 → 320
    KLF15_N; N-terminal domain of Kruppel-like factor 15

  4. XM_006236882.5 → XP_006236944.1  Krueppel-like factor 15 isoform X1

    See identical proteins and their annotated locations for XP_006236944.1

    UniProtKB/TrEMBL
    A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
    Conserved Domains (3) summary
    COG5189
    Location:318 → 400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:322 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd21580
    Location:3 → 320
    KLF15_N; N-terminal domain of Kruppel-like factor 15

  5. XM_063286785.1 → XP_063142855.1  Krueppel-like factor 15 isoform X1

    UniProtKB/TrEMBL
    A6IB85, B2DBE3, Q5FVT6

  6. XM_006236884.5 → XP_006236946.1  Krueppel-like factor 15 isoform X1

    See identical proteins and their annotated locations for XP_006236946.1

    UniProtKB/TrEMBL
    A6IB85, B2DBE3, Q5FVT6, Q9WTQ3
    Conserved Domains (3) summary
    COG5189
    Location:318 → 400
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:322 → 344
    ZF_C2H2; C2H2 Zn finger [structural motif]
    cd21580
    Location:3 → 320
    KLF15_N; N-terminal domain of Kruppel-like factor 15
Nucleotide Protein Strain
Heading Accession and Version

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