SLC45A3 solute carrier family 45 member 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: SLC45A3provided by HGNC
Official Full Name: solute carrier family 45 member 3provided by HGNC
Primary source: HGNC:HGNC:8642
See related: Ensembl:ENSG00000158715 MIM:605097; AllianceGenome:HGNC:8642
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRST; IPCA6; IPCA-2; IPCA-6; IPCA-8; PCANAP2; PCANAP6; PCANAP8
Summary: Predicted to enable sucrose:proton symporter activity. Predicted to be involved in positive regulation of small molecule metabolic process; regulation of oligodendrocyte differentiation; and sucrose transport. Predicted to be located in plasma membrane. Predicted to be active in membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in prostate (RPKM 193.8) and stomach (RPKM 8.4) See more
Orthologs: mouse all
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Genomic context

Location:: 1q32.1

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	1	NC_000001.11 (205657851..205680509, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	1	NC_060925.1 (204922486..204945157, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	1	NC_000001.10 (205626979..205649637, complement)

Chromosome 1 - NC_000001.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prostein expression in human tumors: a tissue microarray study on 19,202 tumors from 152 different Tumor entities.
Title: Prostein expression in human tumors: a tissue microarray study on 19,202 tumors from 152 different Tumor entities.
Mapping genetic variability in mature miRNAs and miRNA binding sites in prostate cancer.
Title: Mapping genetic variability in mature miRNAs and miRNA binding sites in prostate cancer.
Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
Title: Novel loci for childhood body mass index and shared heritability with adult cardiometabolic traits.
Identification of a novel autoimmune peptide epitope of prostein in prostate cancer has been reported.
Title: Identification of a Novel Autoimmune Peptide Epitope of Prostein in Prostate Cancer.
CTCF has a role in regulating SLC45A3-ELK4 Chimeric RNA
Title: Role of CTCF in Regulating SLC45A3-ELK4 Chimeric RNA.
genome-wide association studies show that the top SNP associated with log PSA 9Prostate-specific antigen) levels was rs2153904 in SLC45A3.
Title: Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
Title: Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
This study provides first evidence that the expression of SLC45A3 protein is down regulated through SLC45A3-ERG fusion in prostate cancer.
Title: Loss of SLC45A3 protein (prostein) expression in prostate cancer is associated with SLC45A3-ERG gene rearrangement and an unfavorable clinical course.
Data suggest that chimeric SLC45A3-ELK4 controls prostate cancer cell proliferation, and the chimera level correlates with prostate cancer disease progression.
Title: Chimeric transcript generated by cis-splicing of adjacent genes regulates prostate cancer cell proliferation.
Double sequential immunohistochemical staining with p63 and P501S is highly specific and can be a useful tool in distinguishing urothelial carcinoma from prostate carcinoma.
Title: Diagnostic utility of p63/P501S double sequential immunohistochemical staining in differentiating urothelial carcinoma from prostate carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide association study of serum levels of prostate-specific antigen in the Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. EBI GWAS Catalog EBI GWAS CatalogPubMed
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Slc45a3 (e-PCR), detects polymorphism
- UniSTS:547117

AL033941 (e-PCR)
- UniSTS:93835

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables sucrose:proton symporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables sucrose:proton symporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables sugar transmembrane transporter activity	TAS Traceable Author Statement more info

Process	Evidence Code	Pubs
involved_in hexose transmembrane transport	TAS Traceable Author Statement more info
involved_in positive regulation of fatty acid biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of glucose metabolic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of oligodendrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in sucrose transport	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: solute carrier family 45 member 3

Names: prostate cancer associated protein 2; prostate cancer associated protein 6; prostate cancer associated protein 8; prostate cancer-associated gene 2; prostate cancer-associated gene 6; prostate cancer-associated gene 8; prostein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.