NKD1 NKD inhibitor of WNT signaling pathway 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: NKD1provided by HGNC
Official Full Name: NKD inhibitor of WNT signaling pathway 1provided by HGNC
Primary source: HGNC:HGNC:17045
See related: Ensembl:ENSG00000140807 MIM:607851; AllianceGenome:HGNC:17045
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: Naked1
Summary: In the mouse, Nkd is a Dishevelled (see DVL1; MIM 601365)-binding protein that functions as a negative regulator of the Wnt (see WNT1; MIM 164820)-beta-catenin (see MIM 116806)-Tcf (see MIM 602272) signaling pathway.[supplied by OMIM, Jun 2003]
Expression: Broad expression in lung (RPKM 3.1), brain (RPKM 2.1) and 20 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16q12.1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (50548396..50649249)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (56346149..56446862)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (50582307..50683160)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

[NKD1 promotes glucose uptake in colon cancer cells by activating YWHAE transcription].
Title: [NKD1 promotes glucose uptake in colon cancer cells by activating YWHAE transcription].
Let-7b-5p inhibits colon cancer progression by prohibiting APC ubiquitination degradation and the Wnt pathway by targeting NKD1.
Title: Let-7b-5p inhibits colon cancer progression by prohibiting APC ubiquitination degradation and the Wnt pathway by targeting NKD1.
Clinical Significance of NKD Inhibitor of WNT Signaling Pathway 1 (NKD1) in Glioblastoma.
Title: Clinical Significance of NKD Inhibitor of WNT Signaling Pathway 1 (NKD1) in Glioblastoma.
miR-532 is highly expressed in colorectal cancer cells and directly inhibits NKD1 expression
Title: miR-532 promotes colorectal cancer invasion and metastasis by targeting NKD1.
the downregulation of NKD1 may be involved in the proliferation and migration of osteosarcoma cells through the activation of the canonical Wnt signaling pathway.
Title: Downregulation of NKD1 in human osteosarcoma and its clinical significance.
The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocellular carcinoma cells.
Title: The NKD1/Rac1 feedback loop regulates the invasion and migration ability of hepatocarcinoma cells.
HNF1A-AS1 promoted HCC cell proliferation by repressing the NKD1 and p21 expression.
Title: Long non-coding RNA HNF1A-AS1 promotes hepatocellular carcinoma cell proliferation by repressing NKD1 and P21 expression.
Data indicate that microRNA miR-744 activated Wnt/beta-catenin pathway by targeting multiple negative regulators of Wnt/beta-catenin signaling, including SFRP1, GSK3beta, TLE3 and NKD1, and that NKD1 is a major functional target of miR-744.
Title: MicroRNA-744 promotes prostate cancer progression through aberrantly activating Wnt/β-catenin signaling.
NKD1 showed significantly increased level after induction chemotherapy achieved complete remission in follow-up paired acute myeloid leukemia patients ( p < 0.001). These findings indicated that reduced NKD1 expression is associated with unfavorable clinical outcome in cytogenetically normal acute myeloid leukemia.
Title: Low NKD1 expression predicts adverse prognosis in cytogenetically normal acute myeloid leukemia.
Low NKD1 expression is associated with hepatocellular carcinoma.
Title: NKD1 correlates with a poor prognosis and inhibits cell proliferation by inducing p53 expression in hepatocellular carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (14)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

PMC64968P1 (e-PCR)
- UniSTS:273424

SHGC-58948 (e-PCR)
- UniSTS:94487

RH98401 (e-PCR)
- UniSTS:84519

D16S3035 (e-PCR), detects polymorphism
- UniSTS:1417

D16S541 (e-PCR), detects polymorphism
- UniSTS:29667

G10577 (e-PCR)
- UniSTS:24050

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables PDZ domain binding	IEA Inferred from Electronic Annotation more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in axis elongation	ISS Inferred from Sequence or Structural Similarity more info
involved_in convergent extension	IEA Inferred from Electronic Annotation more info
involved_in eye photoreceptor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of MAPK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Wnt signaling pathway, planar cell polarity pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical Wnt signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell migration involved in somitogenic axis elongation	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in somatic muscle development	ISS Inferred from Sequence or Structural Similarity more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
part_of protein phosphatase type 2A complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: protein naked cuticle homolog 1

Names: Dvl-binding protein; NKD1, WNT signaling pathway inhibitor; naked cuticle homolog 1; naked cuticle-1; naked-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.