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RGS8 regulator of G protein signaling 8 [ Homo sapiens (human) ]

Gene ID: 85397, updated on 5-Mar-2024

Summary

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Official Symbol
RGS8provided by HGNC
Official Full Name
regulator of G protein signaling 8provided by HGNC
Primary source
HGNC:HGNC:16810
See related
Ensembl:ENSG00000135824 MIM:607189; AllianceGenome:HGNC:16810
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
Expression
Biased expression in thyroid (RPKM 1.7), brain (RPKM 1.0) and 3 other tissues See more
Orthologs
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Genomic context

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See RGS8 in Genome Data Viewer
Location:
1q25.3
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (182641818..182752376, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (182001318..182111553, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (182610953..182721511, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1620 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2200 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2202 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2203 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182584000-182584897 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182584926-182585474 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182585475-182586022 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2205 Neighboring gene long intergenic non-protein coding RNA 1686 Neighboring gene regulator of G protein signaling 16 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:182612621-182613820 Neighboring gene long intergenic non-protein coding RNA 1688 Neighboring gene NSE4 homolog A, SMC5-SMC6 complex component pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182711495-182712108 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:182729835-182731034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2207 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:182758561-182759061 Neighboring gene N-acetylneuraminate pyruvate lyase Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2208 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:182808107-182808948 Neighboring gene DHX9 antisense RNA 1 Neighboring gene DExH-box helicase 9

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Regulators of G-protein signaling form a quaternary complex with the agonist, receptor, and G-protein. A novel explanation for the acceleration of signaling activation kinetics. Benians A, et al. J Biol Chem, 2005 Apr 8. PMID 15677457
  2. Participation of RGS8 in the ternary complex of agonist, receptor and G-protein. Benians A, et al. Biochem Soc Trans, 2004 Dec. PMID 15506959
  3. Biochemical and electrophysiological analyses of RGS8 function. Saitoh O, et al. Methods Enzymol, 2004. PMID 15488175
  4. The mechanism of membrane-translocation of regulator of G-protein signaling (RGS) 8 induced by Galpha expression. Masuho I, et al. J Neurochem, 2004 Jan. PMID 14675160
  5. Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain. Song D, et al. J Recept Signal Transduct Res, 2016 Oct. PMID 26754208

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets.
    Title: Key molecules associated with thyroid carcinoma prognosis: A study based on transcriptome sequencing and GEO datasets.
  2. The chimeric RGS8 domains containing the first or the second exon part of RGS5 showed strong inhibitory effects similar to that of wild type RGS8, but the chimeric domain with the third exon part of RGS5 lost its activity
    Title: Potent inhibition of angiotensin AT1 receptor signaling by RGS8: importance of the C-terminal third exon part of its RGS domain.
  3. Missense mutations in RGS8 gene is associated with breast cancer.
    Title: High-resolution melting analysis for mutation screening of RGSL1, RGS16, and RGS8 in breast cancer.
  4. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variations in regulator of G-protein signaling genes as susceptibility loci for second primary tumor/recurrence in head and neck squamous cell carcinoma.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. Spinophilin was identified as an RGS8-interacting protein.
    Title: Spinophilin inhibits the binding of RGS8 to M1-mAChR but enhances the regulatory function of RGS8.
  7. Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
    Title: Association of RGS2 and RGS5 variants with schizophrenia symptom severity.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC119067, MGC119068, MGC119069

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTPase activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in G protein-coupled receptor signaling pathway TAS
Traceable Author Statement
more info
  
involved_in negative regulation of signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of dopamine receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytoplasmic side of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in dendrite ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
regulator of G-protein signaling 8
Names
regulator of G-protein signalling 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102450.3 → NP_001095920.1  regulator of G-protein signaling 8 isoform 2

    See identical proteins and their annotated locations for NP_001095920.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has an additional exon in the 5' region, which results in an alternate 5' coding sequence, as compared to variant 1. The resulting isoform (2) has a shorter and alternate N-terminus, as compared to isoform 1.
    Source sequence(s)
    AL353778
    Consensus CDS
    CCDS41443.1
    UniProtKB/Swiss-Prot
    B4DGL9, P57771, Q3SYD2
    Related
    ENSP00000511884.1, ENST00000515211.2
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  2. NM_001369564.2 → NP_001356493.1  regulator of G-protein signaling 8 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353778
    Consensus CDS
    CCDS41443.1
    UniProtKB/Swiss-Prot
    B4DGL9, P57771, Q3SYD2
    Related
    ENSP00000356527.1, ENST00000367556.5
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  3. NM_001387847.1 → NP_001374776.1  regulator of G-protein signaling 8 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353778, AL513344
    Consensus CDS
    CCDS41443.1
    UniProtKB/Swiss-Prot
    B4DGL9, P57771, Q3SYD2
    Related
    ENSP00000356528.4, ENST00000367557.8
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  4. NM_001387848.1 → NP_001374777.1  regulator of G-protein signaling 8 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AL353778
    Consensus CDS
    CCDS41443.1
    UniProtKB/Swiss-Prot
    B4DGL9, P57771, Q3SYD2
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  5. NM_001387849.1 → NP_001374778.1  regulator of G-protein signaling 8 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AK296514, AL353778
    Consensus CDS
    CCDS41443.1
    UniProtKB/Swiss-Prot
    B4DGL9, P57771, Q3SYD2
    Related
    ENSP00000426289.1, ENST00000483095.6
    Conserved Domains (1) summary
    cd08711
    Location:46 → 170
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  6. NM_033345.4 → NP_203131.1  regulator of G-protein signaling 8 isoform 1

    See identical proteins and their annotated locations for NP_203131.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL353778
    Consensus CDS
    CCDS1349.1
    UniProtKB/Swiss-Prot
    P57771
    Conserved Domains (1) summary
    cd08711
    Location:64 → 188
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    182641818..182752376 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510089.4 → XP_011508391.1  regulator of G-protein signaling 8 isoform X1

    See identical proteins and their annotated locations for XP_011508391.1

    UniProtKB/Swiss-Prot
    P57771
    Related
    ENSP00000258302.4, ENST00000258302.8
    Conserved Domains (1) summary
    cd08711
    Location:64 → 188
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  2. XM_017002631.3 → XP_016858120.1  regulator of G-protein signaling 8 isoform X1

    UniProtKB/Swiss-Prot
    P57771
    Conserved Domains (1) summary
    cd08711
    Location:64 → 188
    RGS_RGS8; Regulator of G protein signaling (RGS) domain found in the RGS8 protein

  3. XM_047432939.1 → XP_047288895.1  regulator of G-protein signaling 8 isoform X2

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    182001318..182111553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339321.1 → XP_054195296.1  regulator of G-protein signaling 8 isoform X1

  2. XM_054339320.1 → XP_054195295.1  regulator of G-protein signaling 8 isoform X1

  3. XM_054339319.1 → XP_054195294.1  regulator of G-protein signaling 8 isoform X1

  4. XM_054339318.1 → XP_054195293.1  regulator of G-protein signaling 8 isoform X1

  5. XM_054339322.1 → XP_054195297.1  regulator of G-protein signaling 8 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P57771.1 GenPept UniProtKB/Swiss-Prot:P57771

Gene LinkOut

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