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Emc9 ER membrane protein complex subunit 9 [ Mus musculus (house mouse) ]

Gene ID: 85308, updated on 3-Apr-2024

Summary

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Official Symbol
Emc9provided by MGI
Official Full Name
ER membrane protein complex subunit 9provided by MGI
Primary source
MGI:MGI:1934682
See related
Ensembl:ENSMUSG00000022217 AllianceGenome:MGI:1934682
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Cgi112; Fam158a; 1500005A01Rik
Summary
Predicted to contribute to membrane insertase activity. Predicted to be involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Predicted to be located in cytoplasm. Predicted to be part of EMC complex. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Orthologous to human EMC9 (ER membrane protein complex subunit 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 23.3), subcutaneous fat pad adult (RPKM 18.2) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
14 C3; 14 28.19 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (55818976..55822832, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (55581519..55585375, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 11 Neighboring gene fat storage-inducing transmembrane protein 1 Neighboring gene proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) Neighboring gene STARR-positive B cell enhancer ABC_E5440 Neighboring gene CapStarr-seq enhancer MGSCv37_chr14:56210161-56210270 Neighboring gene proteasome (prosome, macropain) activator subunit 2 (PA28 beta) Neighboring gene ring finger protein 31

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Nucleotide sequence analysis of the approximately 35-kb segment containing interferon-gamma-inducible mouse proteasome activator genes. Yawata M, et al. Immunogenetics, 2001 Mar. PMID 11345588
  2. The ER membrane protein complex is a transmembrane domain insertase. Guna A, et al. Science, 2018 Jan 26. PMID 29242231, Free PMC Article
  3. BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. Magdaleno S, et al. PLoS Biol, 2006 Apr. PMID 16602821, Free PMC Article
  4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
  5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
contributes_to membrane insertase activity ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein insertion into ER membrane by stop-transfer membrane-anchor sequence ISO
Inferred from Sequence Orthology
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
part_of EMC complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of EMC complex ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ER membrane protein complex subunit 9
Names
UPF0172 protein FAM158A
family with sequence similarity 158, member A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418787.1 → NP_001405716.1  ER membrane protein complex subunit 9 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC174678

  2. NM_001418788.1 → NP_001405717.1  ER membrane protein complex subunit 9 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC174678

  3. NM_001418789.1 → NP_001405718.1  ER membrane protein complex subunit 9 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC174678
    Related
    ENSMUSP00000133463.2, ENSMUST00000174352.8

  4. NM_001418790.1 → NP_001405719.1  ER membrane protein complex subunit 9 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC174678

  5. NM_033146.2 → NP_149158.1  ER membrane protein complex subunit 9 isoform 1

    See identical proteins and their annotated locations for NP_149158.1

    Status: VALIDATED

    Source sequence(s)
    AC174678
    Consensus CDS
    CCDS27117.1
    UniProtKB/Swiss-Prot
    Q9DB76
    UniProtKB/TrEMBL
    Q793L1
    Related
    ENSMUSP00000022828.9, ENSMUST00000022828.9
    Conserved Domains (1) summary
    cd08060
    Location:6 → 188
    MPN_UPF0172; Mov34/MPN/PAD-1 family: UPF0172 family of unknown function includes neighbor of COX4 (Noc4p)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    55818976..55822832 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036158938.1 → XP_036014831.1  ER membrane protein complex subunit 9 isoform X2

    Conserved Domains (1) summary
    pfam03665
    Location:3 → 94
    UPF0172; Uncharacterized protein family (UPF0172)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9DB76.1 GenPept UniProtKB/Swiss-Prot:Q9DB76

Gene LinkOut

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