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TCEAL3 transcription elongation factor A like 3 [ Homo sapiens (human) ]

Gene ID: 85012, updated on 5-Mar-2024

Summary

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Official Symbol
TCEAL3provided by HGNC
Official Full Name
transcription elongation factor A like 3provided by HGNC
Primary source
HGNC:HGNC:28247
See related
Ensembl:ENSG00000196507 AllianceGenome:HGNC:28247
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
WEX8
Summary
This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family contain TFA domains and may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in prostate (RPKM 39.3), brain (RPKM 35.9) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
Xq22.2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (103607963..103609927)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (102054947..102056911)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (102862891..102864855)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29820 Neighboring gene long intergenic non-protein coding RNA 2589 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chrX:102809676-102810875 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:102840363-102841076 Neighboring gene transcription elongation factor A like 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20921 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20922 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29821 Neighboring gene Sharpr-MPRA regulatory region 5968 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29823 Neighboring gene transcription elongation factor A like 1 Neighboring gene CNEP1R1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. Pillutla RC, et al. Genomics, 1999 Mar 1. PMID 10051408
  2. Mammalian BEX, WEX and GASP genes: coding and non-coding chimaerism sustained by gene conversion events. Winter EE, et al. BMC Evol Biol, 2005 Oct 12. PMID 16221301, Free PMC Article
  3. Proteomic and Interactome Approaches Reveal PAK4, PHB-2, and 14-3-3η as Targets of Overactivated Cdc42 in Cellular Responses to Genomic Instability. Silva LE, et al. J Proteome Res, 2019 Oct 4. PMID 31478661
  4. The DNA sequence of the human X chromosome. Ross MT, et al. Nature, 2005 Mar 17. PMID 15772651, Free PMC Article
  5. Proteome-wide identification of HSP70/HSC70 chaperone clients in human cells. Ryu SW, et al. PLoS Biol, 2020 Jul. PMID 32687490, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characterizes TCEAL1, another member of the human TCEAL gene family.
    Title: Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: TCEAL1

Homology

Clone Names

  • MGC15737

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription elongation factor A protein-like 3
Names
TCEA-like protein 3
transcription elongation factor A (SII)-like 3
transcription elongation factor S-II protein-like 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001006933.2 → NP_001006934.1  transcription elongation factor A protein-like 3

    See identical proteins and their annotated locations for NP_001006934.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript.
    Source sequence(s)
    AF163263, BC008703
    Consensus CDS
    CCDS14511.1
    UniProtKB/Swiss-Prot
    D3DXA4, Q969E4
    Related
    ENSP00000243286.3, ENST00000243286.7
    Conserved Domains (2) summary
    pfam04538
    Location:81 → 173
    BEX; Brain expressed X-linked like family
    cl27511
    Location:2 → 104
    Na_Ca_ex; Sodium/calcium exchanger protein

  2. NM_032926.3 → NP_116315.1  transcription elongation factor A protein-like 3

    See identical proteins and their annotated locations for NP_116315.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform.
    Source sequence(s)
    BC008703
    Consensus CDS
    CCDS14511.1
    UniProtKB/Swiss-Prot
    D3DXA4, Q969E4
    Related
    ENSP00000361710.5, ENST00000372627.10
    Conserved Domains (2) summary
    pfam04538
    Location:81 → 173
    BEX; Brain expressed X-linked like family
    cl27511
    Location:2 → 104
    Na_Ca_ex; Sodium/calcium exchanger protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    103607963..103609927
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    102054947..102056911
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q969E4.1 GenPept UniProtKB/Swiss-Prot:Q969E4

Gene LinkOut

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