TNS4 tensin 4 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNS4provided by HGNC
Official Full Name: tensin 4provided by HGNC
Primary source: HGNC:HGNC:24352
See related: Ensembl:ENSG00000131746 MIM:608385; AllianceGenome:HGNC:24352
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CTEN; PP14434
Summary: Predicted to enable actin binding activity. Involved in protein localization. Located in focal adhesion. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in skin (RPKM 23.1), esophagus (RPKM 12.4) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17q21.2

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (40475834..40501623, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (41339341..41365145, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (38632086..38657875, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression.
Title: Epigenetic Activation of Tensin 4 Promotes Gastric Cancer Progression.
Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27.
Title: Nuclear-localized CTEN is a novel transcriptional regulator and promotes cancer cell migration through its downstream target CDC27.
Mining TCGA and GEO databases for the prediction of poor prognosis in lung adenocarcinoma based on up-regulated expression of TNS4.
Title: Mining TCGA and GEO databases for the prediction of poor prognosis in lung adenocarcinoma based on up-regulated expression of TNS4.
CTEN Inhibits Tumor Angiogenesis and Growth by Targeting VEGFA Through Down-Regulation of beta-Catenin in Breast Cancer.
Title: CTEN Inhibits Tumor Angiogenesis and Growth by Targeting VEGFA Through Down-Regulation of β-Catenin in Breast Cancer.
Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion.
Title: Investigating TNS4 in the Colorectal Tumor Microenvironment Using 3D Spheroid Models of Invasion.
Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells.
Title: Histone acetyltransferase p300 mediates the upregulation of CTEN induced by the activation of EGFR signaling in cancer cells.
Tensin4 promotes invasion and migration of gastric cancer cells via regulating AKT/GSK-3beta/snail signaling pathway.
Title: Tensin4 promotes invasion and migration of gastric cancer cells via regulating AKT/GSK-3β/snail signaling pathway.
The authors propose that TNS4 plays a crucial role in CRC tumorigenesis, and that suppression of TNS4 would be an effective therapeutic strategy in treating a subset of cetuximab-refractory CRC patients including KRAS activating mutations.
Title: Whole Transcriptome Analysis Identifies TNS4 as a Key Effector of Cetuximab and a Regulator of the Oncogenic Activity of KRAS Mutant Colorectal Cancer Cell Lines.
analysis of cten force-induced recruitment along keratin network in epithelial cells
Title: Force-induced recruitment of cten along keratin network in epithelial cells.
Src is a novel and functionally important target of the Cten signaling pathway and that Cten protein causes post-transcriptional stabilization of Src in promoting EMT and possibly metastasis in colorectal cancer
Title: Cten promotes Epithelial-Mesenchymal Transition (EMT) in colorectal cancer through stabilisation of Src.

Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH69878 (e-PCR)
- UniSTS:75205

SHGC-83863 (e-PCR)
- UniSTS:101833

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in focal adhesion	IBA Inferred from Biological aspect of Ancestor more info
located_in focal adhesion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tensin-4

Names: C terminal tensin like; C-terminal tensin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_032865.6 → NP_116254.4 tensin-4 precursor

See identical proteins and their annotated locations for NP_116254.4

Status: VALIDATED

Source sequence(s)

AC018629, AF417488, AW378527, AW937802, BC018706, BM710196

Consensus CDS

CCDS11368.1

UniProtKB/Swiss-Prot

A6NMJ7, Q71RB7, Q8IZW8, Q8WV64, Q96JV4

UniProtKB/TrEMBL

A0A2Z4HJF2

Related

ENSP00000254051.6, ENST00000254051.11

Conserved Domains (2) summary

cd01213
Location:580 → 710

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

cl15255
Location:445 → 558

SH2; Src homology 2 (SH2) domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p14 Primary Assembly

Range

40475834..40501623 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005257744.2 → XP_005257801.1 tensin-4 isoform X2

UniProtKB/TrEMBL

A0A2Z4HJF2

Conserved Domains (2) summary

cd01213
Location:579 → 709

PTB_tensin; Tensin Phosphotyrosine-binding (PTB) domain

cl15255
Location:444 → 557

SH2; Src homology 2 (SH2) domain
XM_017025236.2 → XP_016880725.1 tensin-4 isoform X3

UniProtKB/TrEMBL

A0A2Z4HJF2
XM_047436949.1 → XP_047292905.1 tensin-4 isoform X1
XM_047436950.1 → XP_047292906.1 tensin-4 isoform X5
XM_017025237.2 → XP_016880726.1 tensin-4 isoform X4