LINGO1 leucine rich repeat and Ig domain containing 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: LINGO1provided by HGNC
Official Full Name: leucine rich repeat and Ig domain containing 1provided by HGNC
Primary source: HGNC:HGNC:21205
See related: Ensembl:ENSG00000169783 MIM:609791; AllianceGenome:HGNC:21205
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: LERN1; MRT64; LRRN6A; UNQ201
Summary: Predicted to enable epidermal growth factor receptor binding activity. Predicted to act upstream of or within generation of neurons and protein kinase B signaling. Predicted to be located in plasma membrane. Predicted to be active in extracellular matrix and extracellular space. Implicated in autosomal recessive non-syndromic intellectual disability and glaucoma. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in brain (RPKM 24.2), placenta (RPKM 1.9) and 3 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q24.3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (77613027..77820900, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (75473724..75683106, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (77905369..78113242, complement)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Genetic and Epigenetic Regulation in Lingo-1: Effects on Cognitive Function and White Matter Microstructure in a Case-Control Study for Schizophrenia.
Title: Genetic and Epigenetic Regulation in Lingo-1: Effects on Cognitive Function and White Matter Microstructure in a Case-Control Study for Schizophrenia.
Nogo-A and LINGO-1: Two Important Targets for Remyelination and Regeneration.
Title: Nogo-A and LINGO-1: Two Important Targets for Remyelination and Regeneration.
LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-kappaB and JAK2/STAT3.
Title: LINGO-1 shRNA protects the brain against ischemia/reperfusion injury by inhibiting the activation of NF-κB and JAK2/STAT3.
LINGO1 is a regulator of BK channels.
Title: LINGO1 is a regulatory subunit of large conductance, Ca(2+)-activated potassium channels.
LINGO1 might be a positive primary glioblastoma prognostic gene and C7orf31 and VEGFA might be negative prognosticators.
Title: LINGO1, C7orf31 and VEGFA are prognostic genes of primary glioblastoma: analysis of gene expression microarray.
We identified homozygous missense variants in LINGO1, p.(Arg290His) in family F162 and p.(Tyr288Cys) in family PKMR65. Both variants were predicted to be pathogenic, and segregated with the phenotype in the respective families. Molecular modeling of LINGO1 suggests that both variants interfere with the glycosylation of the protein.
Title: Biallelic variants in LINGO1 are associated with autosomal recessive intellectual disability, microcephaly, speech and motor delay.
LINGO1 rs11856808 plays a protective role by decreasing the risk for PD, but not for MSA, in Chinese population.
Title: Analysis and meta-analysis of five polymorphisms of the LINGO1 and LINGO2 genes in Parkinson's disease and multiple system atrophy in a Chinese population.
LINGO1 protein acts as a gateway protein internalizing into the tumor cells when engaged by antibody and can carry antibody conjugated with drugs to kill Ewing sarcoma cells.
Title: Exploring the surfaceome of Ewing sarcoma identifies a new and unique therapeutic target.
Data indicate that leucine-rich repeat neuronal protein 1 (LINGO-1) is intracellular and competes with Nogo-66 receptor (NgR) for binding to p75 neurotrophin receptor (p75NTR).
Title: LINGO-1 protein interacts with the p75 neurotrophin receptor in intracellular membrane compartments.
The results of this study show Increased LINGO1 in the cerebellum of essential tremor patients.
Title: Increased LINGO1 in the cerebellum of essential tremor patients.

Submit: New GeneRIF Correction See all GeneRIFs (50)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Intellectual disability, autosomal recessive 64 MedGen: C4748192 OMIM: 618103 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
A genome-wide association study of the Protein C anticoagulant pathway. EBI GWAS Catalog EBI GWAS CatalogPubMed
Variant in the sequence of the LINGO1 gene confers risk of essential tremor. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

G59824 (e-PCR)
- UniSTS:136973

STS-H11343 (e-PCR)
- UniSTS:21050

SHGC-146402 (e-PCR)
- UniSTS:175199

WI-21778 (e-PCR)
- UniSTS:199

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables epidermal growth factor receptor binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Component	Evidence Code	Pubs
is_active_in extracellular matrix	IBA Inferred from Biological aspect of Ancestor more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	TAS Traceable Author Statement more info

General protein information

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Preferred Names: leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1

Names: leucine rich repeat neuronal 6A; leucine-rich repeat and immunoglobulin domain-containing protein 1; leucine-rich repeat neuronal protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301186.2 → NP_001288115.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288115.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AK027500, BC011057, DA150164, DA232085

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001301187.2 → NP_001288116.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288116.1

Status: VALIDATED

Description

Transcript Variant: This variant (3) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AK027500, BC011057, BI669707, DA232085, DA787289

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001301189.2 → NP_001288118.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288118.1

Status: VALIDATED

Description

Transcript Variant: This variant (4) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AC105133, AK027500, BC011057, BX355455, DA232085, DA494936

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001301191.2 → NP_001288120.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288120.1

Status: VALIDATED

Description

Transcript Variant: This variant (5) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AK027500, BC011057, BI669707, DA483616

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001301192.2 → NP_001288121.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288121.1

Status: VALIDATED

Description

Transcript Variant: This variant (6) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AK027500, BC011057, BI669707, DA182630

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001301194.2 → NP_001288123.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288123.1

Status: VALIDATED

Description

Transcript Variant: This variant (7) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AK027500, BC011057, BI669707, DA525603

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001301195.2 → NP_001288124.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288124.1

Status: VALIDATED

Description

Transcript Variant: This variant (8) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AC105133, AC110607, AK027500, BC011057, BI825536

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001301197.2 → NP_001288126.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288126.1

Status: VALIDATED

Description

Transcript Variant: This variant (9) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AK027500, BC011057, DA328735

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001301198.2 → NP_001288127.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288127.1

Status: VALIDATED

Description

Transcript Variant: This variant (10) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AK027500, BC011057, DB165168

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001301199.2 → NP_001288128.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288128.1

Status: VALIDATED

Description

Transcript Variant: This variant (11) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AK027500, BC011057, DA410114

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_001301200.2 → NP_001288129.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform b precursor

See identical proteins and their annotated locations for NP_001288129.1

Status: VALIDATED

Description

Transcript Variant: This variant (12) contains alternate 5' exon structure and thus differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (b) is shorter at the N-terminus, compared to isoform a. Variants 2 through 12 all encode isoform b.

Source sequence(s)

AK027500, BC011057, BC068558, DA183673

Consensus CDS

CCDS73766.1

UniProtKB/Swiss-Prot

Q96FE5

Related

ENSP00000453853.1, ENST00000561030.5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
NM_032808.7 → NP_116197.4 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform a precursor

See identical proteins and their annotated locations for NP_116197.4

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes the longer isoform (a).

Source sequence(s)

AC046168, AK027500, BC011057, BI523562

Consensus CDS

CCDS45313.1

UniProtKB/Swiss-Prot

D3DW80, Q6NUK3, Q6UXM3, Q6VVG0, Q6VVG1, Q6VVG2, Q8N3K5, Q96FE5, Q96K52

Related

ENSP00000347451.6, ENST00000355300.7

Conserved Domains (6) summary

TIGR00864
Location:341 → 421

PCC; polycystin cation channel protein

smart00013
Location:41 → 75

LRRNT; Leucine rich repeat N-terminal domain

COG4886
Location:66 → 371

LRR; Leucine-rich repeat (LRR) protein [Transcription]

sd00033
Location:73 → 96

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:120 → 179

LRR_8; Leucine rich repeat

cl11960
Location:439 → 514

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

77613027..77820900 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017022682.2 → XP_016878171.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_024450091.2 → XP_024305859.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42
XM_011522118.3 → XP_011520420.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1

See identical proteins and their annotated locations for XP_011520420.1

UniProtKB/Swiss-Prot

Q96FE5

Conserved Domains (6) summary

TIGR00864
Location:335 → 415

PCC; polycystin cation channel protein

smart00013
Location:35 → 69

LRRNT; Leucine rich repeat N-terminal domain

sd00033
Location:67 → 90

LRR_RI; leucine-rich repeat [structural motif]

pfam13855
Location:114 → 173

LRR_8; Leucine rich repeat

cd20969
Location:417 → 508

IgI_Lingo-1; Immunoglobulin I-set domain of the Leucine-rich repeat and immunoglobin-like domain-containing protein 1 (Lingo-1)

cd21340
Location:184 → 365

PPP1R42; protein phosphatase 1 regulatory subunit 42

Alternate T2T-CHM13v2.0

Genomic

NC_060939.1 Alternate T2T-CHM13v2.0

Range

75473724..75683106 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054379006.1 → XP_054234981.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1
XM_054379005.1 → XP_054234980.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1
XM_054379007.1 → XP_054234982.1 leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 isoform X1