U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

C1orf198 chromosome 1 open reading frame 198 [ Homo sapiens (human) ]

Gene ID: 84886, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
C1orf198provided by HGNC
Official Full Name
chromosome 1 open reading frame 198provided by HGNC
Primary source
HGNC:HGNC:25900
See related
Ensembl:ENSG00000119280 AllianceGenome:HGNC:25900
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung (RPKM 42.9), brain (RPKM 27.3) and 24 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q42.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (230837119..230869591, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (230217591..230250079, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (230972865..231005337, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 79 Neighboring gene uncharacterized LOC124904548 Neighboring gene VISTA enhancer hs1766 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:230990988-230992187 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:231004239-231004830 Neighboring gene uncharacterized LOC101927604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231012485-231012986 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231012987-231013486 Neighboring gene uncharacterized LOC124904547 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:231024325-231024499 Neighboring gene uncharacterized LOC105373167 Neighboring gene RNA, 7SL, cytoplasmic 837, pseudogene

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. CD95/Fas suppresses NF-κB activation through recruitment of KPC2 in a CD95L/FasL-independent mechanism. Guégan JP, et al. iScience, 2021 Dec 17. PMID 34917906, Free PMC Article
  2. High Throughput Chemical Screening Reveals Multiple Regulatory Proteins on FOXA1 in Breast Cancer Cell Lines. Wang S, et al. Int J Mol Sci, 2018 Dec 19. PMID 30572598, Free PMC Article
  3. Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B. Hunter MR, et al. J Mol Biol, 2018 Jul 6. PMID 29778605, Free PMC Article
  4. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. Gevaert K, et al. Nat Biotechnol, 2003 May. PMID 12665801
  5. Proteomic Analysis of the EWS-Fli-1 Interactome Reveals the Role of the Lysosome in EWS-Fli-1 Turnover. Elzi DJ, et al. J Proteome Res, 2014 Aug 1. PMID 24999758, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • FLJ14525, FLJ16283, FLJ38847, MGC10710, DKFZp667D152

Gene Ontology Provided by GOA

Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  

General protein information

Go to the top of the page Help
Preferred Names
uncharacterized protein C1orf198

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001136494.2 → NP_001129966.1  uncharacterized protein C1orf198 isoform 2

    See identical proteins and their annotated locations for NP_001129966.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK096166, AL118511, BC066649
    Consensus CDS
    CCDS44330.1
    UniProtKB/Swiss-Prot
    Q9H425
    Related
    ENSP00000428172.1, ENST00000470540.5
    Conserved Domains (1) summary
    pfam15797
    Location:1 → 93
    DUF4706; Domain of unknown function (DUF4706)

  2. NM_001136495.2 → NP_001129967.1  uncharacterized protein C1orf198 isoform 3

    See identical proteins and their annotated locations for NP_001129967.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (3) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AK292433, BC066649, DA333501
    Consensus CDS
    CCDS44331.1
    UniProtKB/Swiss-Prot
    Q9H425
    Related
    ENSP00000430967.1, ENST00000523410.1

  3. NM_032800.3 → NP_116189.1  uncharacterized protein C1orf198 isoform 1

    See identical proteins and their annotated locations for NP_116189.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL118511
    Consensus CDS
    CCDS1587.1
    UniProtKB/Swiss-Prot
    A8K8R8, B3KTW1, G5EA08, Q9H425
    Related
    ENSP00000355623.5, ENST00000366663.10
    Conserved Domains (1) summary
    pfam15797
    Location:31 → 131
    DUF4706; Domain of unknown function (DUF4706)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    230837119..230869591 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432496.1 → XP_047288452.1  uncharacterized protein C1orf198 isoform X2

  2. XM_047432495.1 → XP_047288451.1  uncharacterized protein C1orf198 isoform X1

  3. XM_017002599.3 → XP_016858088.1  uncharacterized protein C1orf198 isoform X4

    UniProtKB/Swiss-Prot
    Q9H425

  4. XM_047432504.1 → XP_047288460.1  uncharacterized protein C1orf198 isoform X4

  5. XM_047432497.1 → XP_047288453.1  uncharacterized protein C1orf198 isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    230217591..230250079 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054339266.1 → XP_054195241.1  uncharacterized protein C1orf198 isoform X2

  2. XM_054339265.1 → XP_054195240.1  uncharacterized protein C1orf198 isoform X1

  3. XM_054339267.1 → XP_054195242.1  uncharacterized protein C1orf198 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H425.1 GenPept UniProtKB/Swiss-Prot:Q9H425

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous