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KLF11 KLF transcription factor 11 [ Homo sapiens (human) ]

Gene ID: 8462, updated on 3-Apr-2024

Summary

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Official Symbol
KLF11provided by HGNC
Official Full Name
KLF transcription factor 11provided by HGNC
Primary source
HGNC:HGNC:11811
See related
Ensembl:ENSG00000172059 MIM:603301; AllianceGenome:HGNC:11811
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FKLF; FKLF1; MODY7; TIEG2; Tieg3
Summary
The protein encoded by this gene is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters. This binding inhibits cell growth and causes apoptosis. Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7). Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Apr 2010]
Expression
Ubiquitous expression in testis (RPKM 20.2), lung (RPKM 12.4) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
2p25.1
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (10043550..10054836)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (10072326..10083576)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (10183677..10194963)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene KLF11-I enhancer Neighboring gene uncharacterized LOC112268412 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:10170473-10170643 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10173619-10174119 Neighboring gene KLF11 promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11151 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11152 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11153 Neighboring gene KLF11 divergent transcript Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10185594-10186333 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10188595-10189095 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10197717-10198660 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:10198661-10199603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10200462-10201324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10201325-10202185 Neighboring gene cystin 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10203342-10203940 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10203941-10204538 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10204790-10205668 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10205669-10206546 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:10211417-10211918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11155 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11157 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15296 Neighboring gene uncharacterized LOC124900536

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant in a Three-Generation Family with MODY7. Guan G, et al. Horm Metab Res, 2023 Feb. PMID 36241199
  2. Endothelial KLF11 as a Nephroprotectant in AKI. Ghajar-Rahimi G, et al. Kidney360, 2022 Aug 25. PMID 36176668, Free PMC Article
  3. KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury. Nath KA, et al. Kidney360, 2022 Aug 25. PMID 36176648, Free PMC Article
  4. A novel KLF11 variant in a family with maturity-onset diabetes of the young. Wu S, et al. Pediatr Diabetes, 2022 Aug. PMID 35689450
  5. KLF11 promotes the progression of glioma via regulating Holliday junction recognition protein. Li J, et al. Cell Biol Int, 2022 Jul. PMID 35293659

See all (79) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Maturity-onset diabetes of the young type 7 (MODY7) and mutation in the Kruppel-like transcription factor 11 (KLF11) gene.
    Title: Maturity-onset diabetes of the young type 7 (MODY7) and mutation in the Krüppel-like transcription factor 11 (KLF11) gene.
  2. Maturity-onset Diabetes of the Young Type 7 (MODY7) and the Kruppellike Factor 11 Mutation (KLF11). A Review.
    Title: Maturity-onset Diabetes of the Young Type 7 (MODY7) and the Krüppellike Factor 11 Mutation (KLF11). A Review.
  3. KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.
    Title: KLF11 regulates lung adenocarcinoma ferroptosis and chemosensitivity by suppressing GPX4.
  4. Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant in a Three-Generation Family with MODY7.
    Title: Genetic and Functional Analyses of the Novel KLF11 Pro193Thr Variant in a Three-Generation Family with MODY7.
  5. Endothelial KLF11 as a Nephroprotectant in AKI.
    Title: Endothelial KLF11 as a Nephroprotectant in AKI.
  6. KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury.
    Title: KLF11 Is a Novel Endogenous Protectant against Renal Ischemia-Reperfusion Injury.
  7. A novel KLF11 variant in a family with maturity-onset diabetes of the young.
    Title: A novel KLF11 variant in a family with maturity-onset diabetes of the young.
  8. KLF11 promotes the progression of glioma via regulating Holliday junction recognition protein.
    Title: KLF11 promotes the progression of glioma via regulating Holliday junction recognition protein.
  9. KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression.
    Title: KLF11 Protects against Venous Thrombosis via Suppressing Tissue Factor Expression.
  10. Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.
    Title: Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.
Submit: New GeneRIF Correction See all GeneRIFs (57)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
Inferred from Sequence Alignment
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transcription cis-regulatory region binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to peptide IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of positive regulation of apoptotic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of regulation of G1/S transition of mitotic cell cycle IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of chromatin ISA
Inferred from Sequence Alignment
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
located_in nuclear body IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Krueppel-like factor 11
Names
Kruppel like factor 11
TGFB-inducible early growth response protein 2
TIEG-2
transforming growth factor-beta-inducible early growth response protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017199.2 RefSeqGene

    Range
    5002..16288
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001177716.2 → NP_001171187.1  Krueppel-like factor 11 isoform b

    See identical proteins and their annotated locations for NP_001171187.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC104794
    Consensus CDS
    CCDS54333.1
    UniProtKB/TrEMBL
    B7ZAX4
    Related
    ENSP00000444690.1, ENST00000540845.5
    Conserved Domains (4) summary
    COG5048
    Location:376 → 432
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:437 → 459
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:423 → 446
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001177718.2 → NP_001171189.1  Krueppel-like factor 11 isoform b

    See identical proteins and their annotated locations for NP_001171189.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AC104794
    Consensus CDS
    CCDS54333.1
    UniProtKB/TrEMBL
    B7ZAX4
    Related
    ENSP00000442722.1, ENST00000535335.1
    Conserved Domains (4) summary
    COG5048
    Location:376 → 432
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:382 → 401
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:437 → 459
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:423 → 446
    zf-H2C2_2; Zinc-finger double domain

  3. NM_003597.5 → NP_003588.1  Krueppel-like factor 11 isoform a

    See identical proteins and their annotated locations for NP_003588.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (a).
    Source sequence(s)
    AC104794
    Consensus CDS
    CCDS1668.1
    UniProtKB/Swiss-Prot
    B4DZE7, O14901, Q9EPF4
    UniProtKB/TrEMBL
    B2RCZ6, Q53QU8
    Related
    ENSP00000307023.1, ENST00000305883.6
    Conserved Domains (4) summary
    COG5048
    Location:393 → 449
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:399 → 418
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:454 → 476
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:440 → 463
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    10043550..10054836
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047446025.1 → XP_047301981.1  Krueppel-like factor 11 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    10072326..10083576
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344204.1 → XP_054200179.1  Krueppel-like factor 11 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O14901.2 GenPept UniProtKB/Swiss-Prot:O14901

Gene LinkOut

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