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Rnf123 ring finger protein 123 [ Mus musculus (house mouse) ]

Gene ID: 84585, updated on 23-Apr-2024

Summary

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Official Symbol
Rnf123provided by MGI
Official Full Name
ring finger protein 123provided by MGI
Primary source
MGI:MGI:2148796
See related
Ensembl:ENSMUSG00000041528 AllianceGenome:MGI:2148796
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kpc1
Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in proteolysis involved in cellular protein catabolic process. Predicted to be located in cytosol and nuclear membrane. Predicted to be active in cytoplasm. Is expressed in liver. Orthologous to human RNF123 (ring finger protein 123). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver E14.5 (RPKM 28.3), spleen adult (RPKM 26.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
9 F1; 9 59.07 cM
Exon count:
40
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (107928869..107957183, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108051672..108080352, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4930535L15 gene Neighboring gene cadherin-related family member 4 Neighboring gene STARR-positive B cell enhancer ABC_E61 Neighboring gene inositol hexaphosphate kinase 1 Neighboring gene STARR-positive B cell enhancer ABC_E2305 Neighboring gene STARR-positive B cell enhancer ABC_E6803 Neighboring gene STARR-positive B cell enhancer ABC_E3859 Neighboring gene GDP-mannose pyrophosphorylase B Neighboring gene adhesion molecule with Ig like domain 3 Neighboring gene microRNA 7088 Neighboring gene macrophage stimulating 1 (hepatocyte growth factor-like) Neighboring gene STARR-positive B cell enhancer ABC_E2914 Neighboring gene acylpeptide hydrolase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. E3 ubiquitin ligase RNF123-deficient mice exhibit reduced parasitemia and mortality in rodent malaria (Plasmodium yoelii 17XL) infection. Miyasaka Y, et al. Parasitol Int, 2022 Jun. PMID 35063657
  2. Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation. Tashiro R, et al. J Cell Physiol, 2021 Nov. PMID 33973242
  3. Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model. Susaki E, et al. Proc Natl Acad Sci U S A, 2009 Mar 31. PMID 19276117, Free PMC Article
  4. Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Kamura T, et al. Nat Cell Biol, 2004 Dec. PMID 15531880
  5. USP19 deubiquitinating enzyme supports cell proliferation by stabilizing KPC1, a ubiquitin ligase for p27Kip1. Lu Y, et al. Mol Cell Biol, 2009 Jan. PMID 19015242, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E3 ubiquitin ligase RNF123-deficient mice exhibit reduced parasitemia and mortality in rodent malaria (Plasmodium yoelii 17XL) infection.
    Title: E3 ubiquitin ligase RNF123-deficient mice exhibit reduced parasitemia and mortality in rodent malaria (Plasmodium yoelii 17XL) infection.
  2. Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation.
    Title: Dysregulation of Rnf 213 gene contributes to T cell response via antigen uptake, processing, and presentation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1) 
  • Endonuclease-mediated (4)  1 citation

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISO
Inferred from Sequence Orthology
more info
  
enables ubiquitin-protein transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in protein maturation ISO
Inferred from Sequence Orthology
more info
  
involved_in protein polyubiquitination ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis involved in protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
E3 ubiquitin-protein ligase RNF123
Names
RING-type E3 ubiquitin transferase RNF123
kip1 ubiquitination-promoting complex protein 1
ubiquitin ligase
NP_001298081.1
NP_001408507.1
NP_001408508.1
NP_115932.1
XP_006511941.1
XP_006511942.1
XP_030100604.1
XP_030100605.1
XP_036011311.1
XP_036011312.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001311152.2 → NP_001298081.1  E3 ubiquitin-protein ligase RNF123 isoform 1

    See identical proteins and their annotated locations for NP_001298081.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC137678
    Consensus CDS
    CCDS81072.1
    UniProtKB/TrEMBL
    Q05CH9
    Related
    ENSMUSP00000125745.2, ENSMUST00000162355.8
    Conserved Domains (2) summary
    cd12882
    Location:123 → 250
    SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
    cd16541
    Location:1258 → 1298
    RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

  2. NM_001421578.1 → NP_001408507.1  E3 ubiquitin-protein ligase RNF123 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC137678

  3. NM_001421579.1 → NP_001408508.1  E3 ubiquitin-protein ligase RNF123 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC137678
    UniProtKB/Swiss-Prot
    Q5XPI3, Q6PGE0

  4. NM_032543.3 → NP_115932.1  E3 ubiquitin-protein ligase RNF123 isoform 2

    See identical proteins and their annotated locations for NP_115932.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and uses an alternate in-frame splice site in the central coding region compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AC137678
    Consensus CDS
    CCDS52922.1
    UniProtKB/Swiss-Prot
    Q5XPI3, Q6PGE0
    UniProtKB/TrEMBL
    Q05CH9
    Related
    ENSMUSP00000125495.3, ENSMUST00000160649.9
    Conserved Domains (2) summary
    cd12882
    Location:123 → 250
    SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
    cd16541
    Location:1252 → 1292
    RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

RNA

  1. NR_185313.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC137678

  2. NR_185314.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC137678

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    107928869..107957183 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006511879.5 → XP_006511942.1  E3 ubiquitin-protein ligase RNF123 isoform X1

    See identical proteins and their annotated locations for XP_006511942.1

    UniProtKB/TrEMBL
    Q05CH9
    Related
    ENSMUST00000161673.8
    Conserved Domains (2) summary
    cd12882
    Location:123 → 250
    SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
    cd16541
    Location:1258 → 1298
    RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

  2. XM_006511878.4 → XP_006511941.1  E3 ubiquitin-protein ligase RNF123 isoform X1

    See identical proteins and their annotated locations for XP_006511941.1

    UniProtKB/TrEMBL
    Q05CH9
    Conserved Domains (2) summary
    cd12882
    Location:123 → 250
    SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
    cd16541
    Location:1258 → 1298
    RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

  3. XM_036155418.1 → XP_036011311.1  E3 ubiquitin-protein ligase RNF123 isoform X2

    UniProtKB/TrEMBL
    Q05CH9
    Conserved Domains (2) summary
    cd12882
    Location:123 → 250
    SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123
    cd16541
    Location:1254 → 1294
    RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

  4. XM_030244744.2 → XP_030100604.1  E3 ubiquitin-protein ligase RNF123 isoform X5

    Conserved Domains (1) summary
    cd16541
    Location:877 → 917
    RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

  5. XM_030244745.2 → XP_030100605.1  E3 ubiquitin-protein ligase RNF123 isoform X6

    Conserved Domains (1) summary
    cd16541
    Location:871 → 911
    RING-HC_RNF123; RING finger, HC subclass, found in RING finger protein 123 (RNF123) and similar proteins

  6. XM_036155419.1 → XP_036011312.1  E3 ubiquitin-protein ligase RNF123 isoform X4

    UniProtKB/TrEMBL
    Q05CH9
    Conserved Domains (1) summary
    cd12882
    Location:123 → 250
    SPRY_RNF123; SPRY domain at N-terminus of ring finger protein 123

RNA

  1. XR_004935615.1 RNA Sequence

  2. XR_004935614.1 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5XPI3.1 GenPept UniProtKB/Swiss-Prot:Q5XPI3

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