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Cd96 CD96 antigen [ Mus musculus (house mouse) ]

Gene ID: 84544, updated on 5-Mar-2024

Summary

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Official Symbol
Cd96provided by MGI
Official Full Name
CD96 antigenprovided by MGI
Primary source
MGI:MGI:1934368
See related
Ensembl:ENSMUSG00000022657 AllianceGenome:MGI:1934368
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Tactile; 1700109I12Rik
Summary
Acts upstream of or within negative regulation of interferon-gamma production; negative regulation of natural killer cell cytokine production; and response to lipopolysaccharide. Predicted to be located in cytoplasm. Is expressed in several structures, including blood; central nervous system; ganglia; heart; and lung. Human ortholog(s) of this gene implicated in C syndrome. Orthologous to human CD96 (CD96 molecule). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thymus adult (RPKM 13.8), testis adult (RPKM 6.8) and 3 other tissues See more
Orthologs
human all
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Genomic context

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Location:
16 B5; 16 30.45 cM
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (45856015..45940611, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (46035652..46120248, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 24754 Neighboring gene predicted gene, 31198 Neighboring gene zinc finger BED-type containing 2 Neighboring gene STARR-seq mESC enhancer starr_40924 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46104635-46104888 Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:46120234-46120417 Neighboring gene adenosylhomocysteinase like Neighboring gene predicted gene, 26297

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CD96 functions as a co-stimulatory receptor to enhance CD8(+) T cell activation and effector responses. Chiang EY, et al. Eur J Immunol, 2020 Jun. PMID 32043568
  2. CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells. Stanko K, et al. Proc Natl Acad Sci U S A, 2018 Mar 27. PMID 29531070, Free PMC Article
  3. The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1. Seth S, et al. Biochem Biophys Res Commun, 2007 Dec 28. PMID 17971293
  4. Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz trigonocephaly) syndrome. Kaname T, et al. Am J Hum Genet, 2007 Oct. PMID 17847009, Free PMC Article
  5. BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer. Feng M, et al. Signal Transduct Target Ther, 2021 Aug 20. PMID 34417435, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer.
    Title: BCL9 regulates CD226 and CD96 checkpoints in CD8(+) T cells to improve PD-1 response in cancer.
  2. CD96 functions as a co-stimulatory receptor to enhance CD8(+) T cell activation and effector responses.
    Title: CD96 functions as a co-stimulatory receptor to enhance CD8(+) T cell activation and effector responses.
  3. Blockade of CD96 completely restored the expansion and inflammatory properties of CD96(high) Th9 cells
    Title: CD96 expression determines the inflammatory potential of IL-9-producing Th9 cells.
  4. knock-out mice display hyperinflammatory responses to lipopolysaccharide and resistance to lung carcinogenesis
    Title: The receptors CD96 and CD226 oppose each other in the regulation of natural killer cell functions.
  5. CD96-driven adhesion to CD155 may be crucial in developmental processes
    Title: CD96 interaction with CD155 via its first Ig-like domain is modulated by alternative splicing or mutations in distal Ig-like domains.
  6. These results suggest a function of the CD96/CD155-adhesion system in T cell biology.
    Title: The murine pan T cell marker CD96 is an adhesion receptor for CD155 and nectin-1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (7) 

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cell-matrix adhesion ISO
Inferred from Sequence Orthology
more info
 PubMed 
acts_upstream_of_or_within cytokine production involved in inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of natural killer cell cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of natural killer cell cytokine production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within negative regulation of type II interferon production IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to lipopolysaccharide IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
T-cell surface protein tactile
Names
T cell activation, increased late expression
cell surface antigen CD96
t cell-activated increased late expression protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032465.2 → NP_115854.2  T-cell surface protein tactile precursor

    See identical proteins and their annotated locations for NP_115854.2

    Status: VALIDATED

    Source sequence(s)
    AK040539, BC052865
    Consensus CDS
    CCDS37348.1
    UniProtKB/Swiss-Prot
    Q3U0X8, Q7TMW0, Q8C9U6, Q99M67
    Related
    ENSMUSP00000023336.10, ENSMUST00000023336.10
    Conserved Domains (1) summary
    cl11960
    Location:43 → 131
    Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    45856015..45940611 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317168.2 → XP_017172657.1  T-cell surface protein tactile isoform X1

    Conserved Domains (1) summary
    cl11960
    Location:111 → 188
    Ig; Immunoglobulin domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3U0X8.1 GenPept UniProtKB/Swiss-Prot:Q3U0X8

Gene LinkOut

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