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PLPP5 phospholipid phosphatase 5 [ Homo sapiens (human) ]

Gene ID: 84513, updated on 3-Apr-2024

Summary

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Official Symbol
PLPP5provided by HGNC
Official Full Name
phospholipid phosphatase 5provided by HGNC
Primary source
HGNC:HGNC:25026
See related
Ensembl:ENSG00000147535 MIM:610626; AllianceGenome:HGNC:25026
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DPPL1; HTPAP; PPAPDC1B
Summary
Enables diacylglycerol diphosphate phosphatase activity and phosphatidate phosphatase activity. Involved in phospholipid dephosphorylation. Predicted to be located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in prostate (RPKM 24.6), duodenum (RPKM 12.1) and 25 other tissues See more
Orthologs
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Genomic context

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See PLPP5 in Genome Data Viewer
Location:
8p11.23
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (38263130..38269224, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (38540085..38546179, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (38120648..38126742, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:38032979-38033836 Neighboring gene RNA, U6 small nuclear 323, pseudogene Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38033837-38034694 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27245 Neighboring gene LSM1 homolog, mRNA degradation associated Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27246 Neighboring gene BAG cochaperone 4 Neighboring gene Sharpr-MPRA regulatory region 4585 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19117 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38089405-38089904 Neighboring gene DDHD domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19119 Neighboring gene nuclear receptor binding SET domain protein 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19120 Neighboring gene NUP98-NSD3 recombination region Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27247 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38235530-38236031 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38238312-38238846 Neighboring gene H3K27ac hESC enhancer GRCh37_chr8:38239137-38239927 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19122 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19123 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:38242638-38243268 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr8:38243269-38243898 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38244052-38244553 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19125 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38247000-38247501 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38248280-38248781 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38257600-38258101 Neighboring gene uncharacterized LOC102723716 Neighboring gene OCT4-H3K4me1 hESC enhancer GRCh37_chr8:38261681-38262180 Neighboring gene OCT4 hESC enhancer GRCh37_chr8:38262831-38263332 Neighboring gene leucine zipper and EF-hand containing transmembrane protein 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma. Wu JC, et al. PLoS One, 2014. PMID 24603412, Free PMC Article
  2. Association of specific genotypes in metastatic suppressor HTPAP with tumor metastasis and clinical prognosis in hepatocellular carcinoma. Ren N, et al. Cancer Res, 2011 May 1. PMID 21531764
  3. Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinoma. Dai C, et al. Cancer Sci, 2011 Mar. PMID 21219541
  4. HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma. Wu X, et al. Oncogene, 2006 Mar 16. PMID 16261160
  5. PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors. Mahmood SF, et al. Am J Pathol, 2013 Nov. PMID 24051013

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. genetic variants at loci -1053 and +64 of the HTPAP promoter affect the expression of HTPAP, which might be a novel determinant and target for HCC prognosis
    Title: Genomic aberrations in the HTPAP promoter affect tumor metastasis and clinical prognosis of hepatocellular carcinoma.
  2. PPAPDC1B and WHSC1L1 played a major role in regulating the survival of breast cancer, pancreatic adenocarcinoma and small-cell lung cancer-derived cell lines.
    Title: PPAPDC1B and WHSC1L1 are common drivers of the 8p11-12 amplicon, not only in breast tumors but also in pancreatic adenocarcinomas and lung tumors.
  3. Findings identify an HTPAP genotype and associated gene expression pattern that favors metastasis progression and that could be used to predict tumor metastasis and prognosis in HCC patients.
    Title: Association of specific genotypes in metastatic suppressor HTPAP with tumor metastasis and clinical prognosis in hepatocellular carcinoma.
  4. HTPAP-1 may be the transcript of HTPAP to exhibit a suppressive role on hepatocellular cancer(HCC) metastasis, and can be a prognostic marker for HCC.
    Title: Downregulation of HTPAP transcript variant 1 correlates with tumor metastasis and poor survival in patients with hepatocellular carcinoma.
  5. microarray experiments on PPAPDC1B knockdown indicated this gene interfered with cell signaling pathways, including Janus-activated kinase-signal transducer and activator of transcription, mitogen-activated protein kinase, and protein kinase C pathways
    Title: Characterization of the recurrent 8p11-12 amplicon identifies PPAPDC1B, a phosphatase protein, as a new therapeutic target in breast cancer.
  6. DPPL1 and DPPL2 represent a novel type of mammalian phosphatidate phosphatase.
    Title: Cloning and characterization of DPPL1 and DPPL2, representatives of a novel type of mammalian phosphatidate phosphatase.
  7. HTPAP is a novel metastatic suppressor gene for hepatocellular carcinoma
    Title: HTPAP gene on chromosome 8p is a candidate metastasis suppressor for human hepatocellular carcinoma.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables diacylglycerol diphosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in phospholipid dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phospholipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
phospholipid phosphatase 5
Names
diacylglycerol pyrophosphate like 1
diacylglycerol pyrophosphate phosphatase-like 1
phosphatidate phosphatase PPAPDC1B
phosphatidic acid phosphatase type 2 domain containing 1B
phosphatidic acid phosphatase type 2 domain-containing protein 1B
testicular secretory protein Li 38
NP_001096029.1
NP_001096030.1
NP_001341381.1
NP_001341383.1
NP_001341385.1
NP_001341386.1
NP_001341387.1
NP_001341388.1
NP_001397849.1
NP_115872.2
XP_011542974.1
XP_011542976.2
XP_011542977.2
XP_016869394.2
XP_024303074.1
XP_024303075.2
XP_047278277.1
XP_047278279.1
XP_054217329.1
XP_054217330.1
XP_054217331.1
XP_054217332.1
XP_054217333.1
XP_054217334.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102559.2 → NP_001096029.1  phospholipid phosphatase 5 isoform 1

    See identical proteins and their annotated locations for NP_001096029.1

    Status: VALIDATED

    Source sequence(s)
    AA761242, AC087362, BC033025, BC106014, DB458595
    Consensus CDS
    CCDS47841.1
    UniProtKB/Swiss-Prot
    C9JKF5, Q3KQX6, Q8NEB5, Q9BY45
    UniProtKB/TrEMBL
    A0A140VK38, H0YCQ3
    Related
    ENSP00000392553.2, ENST00000424479.7
    Conserved Domains (1) summary
    cd03390
    Location:43 → 231
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  2. NM_001102560.2 → NP_001096030.1  phospholipid phosphatase 5 isoform 3

    See identical proteins and their annotated locations for NP_001096030.1

    Status: VALIDATED

    Source sequence(s)
    AC087362, BE856962, DB458595
    Consensus CDS
    CCDS47843.1
    UniProtKB/Swiss-Prot
    Q8NEB5
    Related
    ENSP00000414522.2, ENST00000419686.2
    Conserved Domains (1) summary
    cl00474
    Location:43 → 155
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

  3. NM_001354452.2 → NP_001341381.1  phospholipid phosphatase 5 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC087362
    UniProtKB/TrEMBL
    H0YCQ3
    Related
    ENSP00000432122.1, ENST00000524616.5
    Conserved Domains (1) summary
    cd03390
    Location:43 → 213
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  4. NM_001354454.2 → NP_001341383.1  phospholipid phosphatase 5 isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC087362
    Conserved Domains (1) summary
    cd03390
    Location:43 → 240
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  5. NM_001354456.2 → NP_001341385.1  phospholipid phosphatase 5 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC087362
    Conserved Domains (1) summary
    cd03390
    Location:43 → 214
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  6. NM_001354457.2 → NP_001341386.1  phospholipid phosphatase 5 isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC087362
    Conserved Domains (1) summary
    cl00474
    Location:43 → 94
    PAP2_like; PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid ...

  7. NM_001354458.2 → NP_001341387.1  phospholipid phosphatase 5 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC087362
    Consensus CDS
    CCDS87598.1
    UniProtKB/TrEMBL
    E9PNB1
    Conserved Domains (1) summary
    cd03390
    Location:2 → 99
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  8. NM_001354459.2 → NP_001341388.1  phospholipid phosphatase 5 isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC087362
    Consensus CDS
    CCDS87598.1
    UniProtKB/TrEMBL
    E9PNB1
    Related
    ENSP00000437248.1, ENST00000531823.5
    Conserved Domains (1) summary
    cd03390
    Location:2 → 99
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  9. NM_001410920.1 → NP_001397849.1  phospholipid phosphatase 5 isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC087362
    Consensus CDS
    CCDS94281.1
    Related
    ENSP00000434916.1, ENST00000529359.5

  10. NM_032483.4 → NP_115872.2  phospholipid phosphatase 5 isoform 2

    See identical proteins and their annotated locations for NP_115872.2

    Status: VALIDATED

    Source sequence(s)
    AC087362, BC106014, DB458595
    Consensus CDS
    CCDS47842.1
    UniProtKB/Swiss-Prot
    Q8NEB5
    Related
    ENSP00000390622.2, ENST00000422581.6
    Conserved Domains (1) summary
    cd03390
    Location:43 → 211
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

RNA

  1. NR_148893.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087362

  2. NR_148894.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC087362

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

    Range
    38263130..38269224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024447307.2 → XP_024303075.2  phospholipid phosphatase 5 isoform X8

  2. XM_024447306.2 → XP_024303074.1  phospholipid phosphatase 5 isoform X7

    UniProtKB/TrEMBL
    E9PNB1
    Conserved Domains (1) summary
    cd03390
    Location:2 → 99
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  3. XM_047422323.1 → XP_047278279.1  phospholipid phosphatase 5 isoform X6

  4. XM_011544672.3 → XP_011542974.1  phospholipid phosphatase 5 isoform X1

    See identical proteins and their annotated locations for XP_011542974.1

    UniProtKB/TrEMBL
    A8K7V3
    Conserved Domains (1) summary
    cd03390
    Location:1 → 174
    PAP2_containing_1_like; PAP2, subfamily similar to human phosphatidic_acid_phosphatase_type_2_domain_containing_1. Most likely membrane-associated phosphatidic acid phosphatases. Plant members of this group are constitutively expressed in many tissues and exhibit both ...

  5. XM_047422321.1 → XP_047278277.1  phospholipid phosphatase 5 isoform X5

  6. XM_011544675.4 → XP_011542977.2  phospholipid phosphatase 5 isoform X4

  7. XM_011544674.3 → XP_011542976.2  phospholipid phosphatase 5 isoform X3

  8. XM_017013905.2 → XP_016869394.2  phospholipid phosphatase 5 isoform X2

RNA

  1. XR_001745609.3 RNA Sequence

  2. XR_001745608.3 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060932.1 Alternate T2T-CHM13v2.0

    Range
    38540085..38546179 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054361359.1 → XP_054217334.1  phospholipid phosphatase 5 isoform X8

  2. XM_054361358.1 → XP_054217333.1  phospholipid phosphatase 5 isoform X6

  3. XM_054361354.1 → XP_054217329.1  phospholipid phosphatase 5 isoform X1

  4. XM_054361357.1 → XP_054217332.1  phospholipid phosphatase 5 isoform X4

  5. XM_054361356.1 → XP_054217331.1  phospholipid phosphatase 5 isoform X3

  6. XM_054361355.1 → XP_054217330.1  phospholipid phosphatase 5 isoform X2

RNA

  1. XR_008487886.1 RNA Sequence

  2. XR_008487885.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NEB5.2 GenPept UniProtKB/Swiss-Prot:Q8NEB5

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