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ZNF527 zinc finger protein 527 [ Homo sapiens (human) ]

Gene ID: 84503, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF527provided by HGNC
Official Full Name
zinc finger protein 527provided by HGNC
Primary source
HGNC:HGNC:29385
See related
Ensembl:ENSG00000189164 AllianceGenome:HGNC:29385
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 1.6), ovary (RPKM 1.3) and 25 other tissues See more
Orthologs
all
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Genomic context

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Location:
19q13.12
Exon count:
5
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (37371099..37393066)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (40172613..40194581)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (37862001..37883968)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37763986-37764523 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37764524-37765060 Neighboring gene Putative uncharacterized protein PP6455 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37771594-37772125 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37772126-37772656 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37777707-37778689 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37787960-37788471 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10554 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14541 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:37809147-37810044 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811117-37811765 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr19:37811766-37812414 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37824558-37825500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37825501-37826442 Neighboring gene zinc finger protein 875 Neighboring gene MPRA-validated peak3463 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14544 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14545 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10555 Neighboring gene zinc finger protein 569 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14547 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14548 Neighboring gene zinc finger protein 570 Neighboring gene ZNF793 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37996759-37997550 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:37997551-37998342 Neighboring gene zinc finger protein 793

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF527 GENE rs386809049 ANALYSIS IN POPULATION OF UKRAINE. Gulkovskyi RV, et al. Tsitol Genet, 2015 Jul-Aug. PMID 26419067
  2. Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. Nagase T, et al. DNA Res, 2001 Apr 27. PMID 11347906
  3. Cullin 3 Exon 9 Deletion in Familial Hyperkalemic Hypertension Impairs Cullin3-Ring-E3 Ligase (CRL3) Dynamic Regulation and Cycling. Kouranti I, et al. Int J Mol Sci, 2022 May 5. PMID 35563538, Free PMC Article
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. Ota T, et al. Nat Genet, 2004 Jan. PMID 14702039
  5. Dual proteome-scale networks reveal cell-specific remodeling of the human interactome. Huttlin EL, et al. Cell, 2021 May 27. PMID 33961781, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • KIAA1829

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
zinc finger protein 527

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032453.2 → NP_115829.1  zinc finger protein 527

    See identical proteins and their annotated locations for NP_115829.1

    Status: VALIDATED

    Source sequence(s)
    AC008806, DC341389
    Consensus CDS
    CCDS42559.1
    UniProtKB/Swiss-Prot
    B4DVL5, Q8NB42
    Related
    ENSP00000390179.2, ENST00000436120.7
    Conserved Domains (5) summary
    smart00349
    Location:14 → 74
    KRAB; krueppel associated box
    COG5048
    Location:328 → 490
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:360 → 380
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:400 → 425
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    37371099..37393066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259329.5 → XP_005259386.1  zinc finger protein 527 isoform X1

    See identical proteins and their annotated locations for XP_005259386.1

    UniProtKB/Swiss-Prot
    Q8NB42
    Conserved Domains (5) summary
    smart00349
    Location:14 → 54
    KRAB; krueppel associated box
    COG5048
    Location:296 → 458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:14 → 53
    KRAB; KRAB box
    pfam13465
    Location:368 → 393
    zf-H2C2_2; Zinc-finger double domain

  2. XM_005259328.6 → XP_005259385.1  zinc finger protein 527 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:296 → 458
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:328 → 348
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:368 → 393
    zf-H2C2_2; Zinc-finger double domain

  3. XM_017027381.2 → XP_016882870.1  zinc finger protein 527 isoform X4

    Conserved Domains (3) summary
    COG5048
    Location:264 → 426
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:296 → 316
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:336 → 361
    zf-H2C2_2; Zinc-finger double domain

  4. XM_017027380.2 → XP_016882869.1  zinc finger protein 527 isoform X3

    Conserved Domains (3) summary
    COG5048
    Location:267 → 429
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:299 → 319
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:339 → 364
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    40172613..40194581
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054322359.1 → XP_054178334.1  zinc finger protein 527 isoform X1

  2. XM_054322360.1 → XP_054178335.1  zinc finger protein 527 isoform X2

  3. XM_054322362.1 → XP_054178337.1  zinc finger protein 527 isoform X4

  4. XM_054322361.1 → XP_054178336.1  zinc finger protein 527 isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NB42.2 GenPept UniProtKB/Swiss-Prot:Q8NB42

Gene LinkOut

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