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DUSP11 dual specificity phosphatase 11 [ Homo sapiens (human) ]

Gene ID: 8446, updated on 3-Apr-2024

Summary

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Official Symbol
DUSP11provided by HGNC
Official Full Name
dual specificity phosphatase 11provided by HGNC
Primary source
HGNC:HGNC:3066
See related
Ensembl:ENSG00000144048 MIM:603092; AllianceGenome:HGNC:3066
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIR1
Summary
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
Expression
Ubiquitous expression in esophagus (RPKM 14.8), urinary bladder (RPKM 12.3) and 25 other tissues See more
Orthologs
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Genomic context

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See DUSP11 in Genome Data Viewer
Location:
2p13.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (73762213..73780149, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (73775309..73793243, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73989340..74007230, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124905592 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16031 Neighboring gene TP53RK binding protein Neighboring gene ReSE screen-validated silencer GRCh37_chr2:73981125-73981308 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16032 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16033 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16034 Neighboring gene chromosome 2 open reading frame 78 Neighboring gene uncharacterized LOC105374807 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:74055859-74056077 Neighboring gene STAM binding protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus. Kincaid RP, et al. Proc Natl Acad Sci U S A, 2018 Aug 7. PMID 30038017, Free PMC Article
  2. Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells. Carrillo D, et al. Open Biol, 2017 Nov. PMID 29118270, Free PMC Article
  3. DUSP11 - An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells. Burke JM, et al. RNA Biol, 2017 Nov 2. PMID 28296624, Free PMC Article
  4. DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs. Burke JM, et al. Genes Dev, 2016 Sep 15. PMID 27798849, Free PMC Article
  5. Isolation and characterization of DUSP11, a novel p53 target gene. Caprara G, et al. J Cell Mol Med, 2009 Aug. PMID 19120688, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DUSP11 limits both miR-122-dependent and miR-122-independent Hepatitis C RNA accumulation.
    Title: miR-122 does not impact recognition of the HCV genome by innate sensors of RNA but rather protects the 5' end from the cellular pyrophosphatases, DOM3Z and DUSP11.
  2. Results implicate DUSP11 as an important component of XRN-mediated restriction of hepatitis C virus replication.
    Title: RNA triphosphatase DUSP11 enables exonuclease XRN-mediated restriction of hepatitis C virus.
  3. DUSP11 regulates host and viral non-coding RNAs in mammalian cells.
    Title: DUSP11 - An RNA phosphatase that regulates host and viral non-coding RNAs in mammalian cells.
  4. PIR gene expression is highly dependent on the expression of HR-HPV E6 and E7 oncoproteins HPV-positive cell lines.
    Title: Upregulation of PIR gene expression induced by human papillomavirus E6 and E7 in epithelial oral and cervical cells.
  5. DUSP11 converts the 5' triphosphate of miRNA precursors to a 5' monophosphate, promoting loading of derivative 5p miRNAs into Argonaute proteins via a Dicer-coupled 5' monophosphate-dependent strand selection mechanism.
    Title: DUSP11 activity on triphosphorylated transcripts promotes Argonaute association with noncanonical viral microRNAs and regulates steady-state levels of cellular noncoding RNAs.
  6. the atomic structure of a catalytically inactive mutant (C152S) of the human PIR1 phosphatase core (PIR1-core, residues 29-205), refined at 1.20 A resolution.
    Title: Structure of human PIR1, an atypical dual-specificity phosphatase.
  7. results suggest that DUSP11 contributes to p53-dependent inhibition of cell proliferation and that it might be involved in regulating RNA splicing through SAM68
    Title: Isolation and characterization of DUSP11, a novel p53 target gene.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.
EBI GWAS Catalog
Genetic loci influencing kidney function and chronic kidney disease.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

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Replication interactions

Interaction Pubs
Knockdown of dual specificity phosphatase 11 (RNA/RNP complex 1-interacting, DUSP11) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Potential readthrough

Included gene: TPRKB

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables RNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables polynucleotide 5'-phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables polynucleotide 5'-phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein tyrosine/serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA processing TAS
Traceable Author Statement
more info
 PubMed 
involved_in protein dephosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in fibrillar center IDA
Inferred from Direct Assay
more info
  
located_in intercellular bridge IDA
Inferred from Direct Assay
more info
  
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
RNA/RNP complex-1-interacting phosphatase
Names
RNA/RNP complex 1-interacting
RNA/RNP complex-interacting phosphatase
dual specificity protein phosphatase 11
phosphatase that interacts with RNA/RNP complex 1
serine/threonine specific protein phosphatase
NP_001411578.1
NP_003575.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001424649.1 → NP_001411578.1  RNA/RNP complex-1-interacting phosphatase isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This transcript variant (2) uses upstream transcription and translation start sites compared to transcript variant 1. The encoded isoform (2) has a longer N-terminus than isoform 1.
    Source sequence(s)
    AC092653

  2. NM_003584.3 → NP_003575.3  RNA/RNP complex-1-interacting phosphatase isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This transcript variant (1) encodes isoform 1.
    Source sequence(s)
    AC092653
    Consensus CDS
    CCDS1928.3
    UniProtKB/Swiss-Prot
    B2RCT8, C9JYA6, O75319, Q6AI47, Q9BWE3
    UniProtKB/TrEMBL
    A0A8Q3SIB0
    Related
    ENSP00000272444.4, ENST00000272444.8
    Conserved Domains (1) summary
    cd17665
    Location:34 → 201
    DSP_DUSP11; dual-specificity phosphatase domain of dual specificity protein phosphatase 11 and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    73762213..73780149 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791766.1 Reference GRCh38.p14 PATCHES

    Range
    431711..449647 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    73775309..73793243 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O75319.3 GenPept UniProtKB/Swiss-Prot:O75319

Gene LinkOut

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