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RAB11FIP4 RAB11 family interacting protein 4 [ Homo sapiens (human) ]

Gene ID: 84440, updated on 5-Mar-2024

Summary

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Official Symbol
RAB11FIP4provided by HGNC
Official Full Name
RAB11 family interacting protein 4provided by HGNC
Primary source
HGNC:HGNC:30267
See related
Ensembl:ENSG00000131242 MIM:611999; AllianceGenome:HGNC:30267
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FIP4-Rab11; RAB11-FIP4
Summary
The protein encoded by this gene interacts with RAB11 and is thought to be involved in bringing recycling endosome membranes to the cleavage furrow in late cytokinesis. Hypoxic conditions can lead to an upregulation of the encoded protein and enhance the metastatic potential of hepatocellular carcinoma. [provided by RefSeq, Oct 2016]
Expression
Broad expression in brain (RPKM 25.4), testis (RPKM 6.0) and 17 other tissues See more
Orthologs
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Genomic context

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Location:
17q11.2
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (31391675..31538211)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (32337033..32483971)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (29718693..29865230)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neurofibromin 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12009 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12010 Neighboring gene NF1 intron 50 Alu-mediated recombination region Neighboring gene ecotropic viral integration site 2A Neighboring gene Sharpr-MPRA regulatory region 6872 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29717908-29718497 Neighboring gene adenylate kinase 4 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29727239-29727740 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29738471-29739436 Neighboring gene uncharacterized LOC124903977 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29741367-29742330 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29742806-29743646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29743647-29744486 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29751937-29752664 Neighboring gene uncharacterized LOC105371725 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29760725-29761454 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:29762116-29762616 Neighboring gene H3K27ac hESC enhancer GRCh37_chr17:29762617-29763117 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12011 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29781223-29781724 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29781725-29782224 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29784216-29785064 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29785065-29785912 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29786467-29786968 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29786969-29787468 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29794364-29795058 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:29796711-29797212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29803345-29804161 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8411 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12012 Neighboring gene RNA, 7SL, cytoplasmic 79, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29825931-29826892 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29826893-29827852 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12013 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29836658-29837448 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:29850121-29850755 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29851414-29852028 Neighboring gene Sharpr-MPRA regulatory region 11348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12014 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12015 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12016 Neighboring gene RNA, 7SL, cytoplasmic 45, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8412 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr17:29884070-29884694 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:29886028-29886818 Neighboring gene tRNA-Thr (anticodon CGT) 4-1 Neighboring gene microRNA 4724 Neighboring gene microRNA 193a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. High Rab11-FIP4 expression predicts poor prognosis and exhibits tumor promotion in pancreatic cancer. He Y, et al. Int J Oncol, 2017 Feb. PMID 28035375, Free PMC Article
  2. Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma. Hu F, et al. Oncogene, 2015 Dec 3. PMID 25745995
  3. Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis. Wang JZ, et al. Mol Med Rep, 2018 Mar. PMID 29257314
  4. Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout. Hickson GR, et al. Mol Biol Cell, 2003 Jul. PMID 12857874, Free PMC Article
  5. Tumor susceptibility gene 101 (TSG101) is a novel binding-partner for the class II Rab11-FIPs. Horgan CP, et al. PLoS One, 2012. PMID 22348143, Free PMC Article

See all (29) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Rab11 FIP4 was also discovered through a yeast two-hybrid screen for Arf5 effectors and named Arfophilin-2, as described here. Rab11 FIP4/Arfophilin-2 was shown to localize to a perinuclear compartment, the centrosome, and focal adhesions in HeLa cells. Rab11 FIP4/Arfophilin-2 over-expression was shown to cluster the Rab11-positive endosomal recycling compartment around the centrosome.
    Title: Arfophilins are dual Arf/Rab 11 binding proteins that regulate recycling endosome distribution and are related to Drosophila nuclear fallout.
  2. Rab11-FIP4 expression promotes migration and invasion of colon cancer cells and correlates with poor prognosis.
    Title: Hypoxia-induced Rab11-family interacting protein 4 expression promotes migration and invasion of colon cancer and correlates with poor prognosis.
  3. Our findings suggest that overexpression of Rab11-FIP4 predicts poor clinical outcomes for pancreatic cancer and contributes to pancreatic tumor progression.
    Title: High Rab11-FIP4 expression predicts poor prognosis and exhibits tumor promotion in pancreatic cancer.
  4. Results show the expression of Rab11-FIP4 upregulated in hepatocellular carcinoma (HCC) and correlated with poor prognosis. Rab11-FIP4 dramatically contributed to HCC metastasis via phosphorylation of PRAS40.
    Title: Hypoxia upregulates Rab11-family interacting protein 4 through HIF-1α to promote the metastasis of hepatocellular carcinoma.
  5. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  6. FIP3 and FIP4 serve to couple Rab11-positive vesicle traffic from recycling endosomes to the cleavage furrow/midbody where they are tethered prior to fusion events via interactions with Arf6 and the Exocyst.
    Title: Rab11-FIP3 and FIP4 interact with Arf6 and the exocyst to control membrane traffic in cytokinesis.
  7. Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells.
    Title: Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ00131, KIAA1821, MGC11316, MGC126566

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables small GTPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in endocytic recycling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of cytokinesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
is_active_in cleavage furrow IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cleavage furrow IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular space HDA PubMed 
is_active_in midbody IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in midbody IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in recycling endosome membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in recycling endosome membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in spindle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
rab11 family-interacting protein 4
Names
RAB11 family interacting protein 4 (class II)
arfophilin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051977.1 RefSeqGene

    Range
    5052..151588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001303542.3 → NP_001290471.2  rab11 family-interacting protein 4 isoform 2

    See identical proteins and their annotated locations for NP_001290471.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks three 5' exons but contains an alternate 5' terminal exon, and it thus differs in the 5' UTR and 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AB058724, AJ314646, AK097424, AL831830, BC047674
    Consensus CDS
    CCDS76985.1
    UniProtKB/Swiss-Prot
    Q86YS3
    Related
    ENSP00000378227.2, ENST00000394744.6
    Conserved Domains (2) summary
    COG1196
    Location:238 → 519
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09457
    Location:494 → 534
    RBD-FIP; FIP domain

  2. NM_001346747.2 → NP_001333676.1  rab11 family-interacting protein 4 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC003101, KF510421

  3. NM_001346748.2 → NP_001333677.1  rab11 family-interacting protein 4 isoform 4

    Status: REVIEWED

    Source sequence(s)
    AC003101, AJ314646, KF510421
    UniProtKB/Swiss-Prot
    Q86YS3
    Conserved Domains (2) summary
    pfam09457
    Location:455 → 495
    RBD-FIP; FIP domain
    cl25732
    Location:199 → 480
    SMC_N; RecF/RecN/SMC N terminal domain

  4. NM_001346749.2 → NP_001333678.1  rab11 family-interacting protein 4 isoform 5

    Status: REVIEWED

    Source sequence(s)
    AC003101, AJ314646, DA956442, KF510421
    UniProtKB/Swiss-Prot
    Q86YS3
    Conserved Domains (2) summary
    pfam09457
    Location:336 → 376
    RBD-FIP; FIP domain
    cl25732
    Location:80 → 361
    SMC_N; RecF/RecN/SMC N terminal domain

  5. NM_032932.6 → NP_116321.2  rab11 family-interacting protein 4 isoform 1

    See identical proteins and their annotated locations for NP_116321.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AJ314646, AY169244, BC047674, BC093914
    Consensus CDS
    CCDS11267.1
    UniProtKB/Swiss-Prot
    Q52LI1, Q86YS3, Q8N829, Q8NDT7, Q969D8
    Related
    ENSP00000482620.1, ENST00000621161.5
    Conserved Domains (3) summary
    COG1196
    Location:340 → 621
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam09457
    Location:596 → 636
    RBD-FIP; FIP domain
    pfam13499
    Location:20 → 78
    EF-hand_7; EF-hand domain pair

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    31391675..31538211
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES

Genomic

  1. NW_025791803.1 Reference GRCh38.p14 PATCHES

    Range
    470537..512985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    32337033..32483971
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q86YS3.1 GenPept UniProtKB/Swiss-Prot:Q86YS3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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