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Cdh11 cadherin 11 [ Rattus norvegicus (Norway rat) ]

Gene ID: 84407, updated on 13-Apr-2024

Summary

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Official Symbol
Cdh11provided by RGD
Official Full Name
cadherin 11provided by RGD
Primary source
RGD:619742
See related
Ensembl:ENSRNOG00000013481 AllianceGenome:RGD:619742
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable cadherin binding activity and calcium ion binding activity. Predicted to be involved in several processes, including calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules; cell-cell junction organization; and skin development. Predicted to act upstream of or within corticospinal tract morphogenesis. Predicted to be located in cytoplasm; glutamatergic synapse; and plasma membrane. Predicted to be part of catenin complex. Predicted to be active in Schaffer collateral - CA1 synapse and adherens junction. Human ortholog(s) of this gene implicated in Elsahy-Waters syndrome. Orthologous to human CDH11 (cadherin 11). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Uterus (RPKM 132.1), Lung (RPKM 105.6) and 8 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
19p14
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 19 NC_086037.1 (2152961..2312140)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 19 NC_051354.1 (2148447..2305754)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 19 NC_005118.4 (2391181..2551245)

Chromosome 19 - NC_086037.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC134483296 Neighboring gene U2 spliceosomal RNA Neighboring gene small nucleolar RNA SNORA44 Neighboring gene aldo-keto reductase family 1 member B, pseudogene 5 Neighboring gene basic transcription factor 3 like 8

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. Estradiol promotes M1-like macrophage activation through cadherin-11 to aggravate temporomandibular joint inflammation in rats. Kou XX, et al. J Immunol, 2015 Mar 15. PMID 25681337
  2. Pressure and inflammatory stimulation induced increase of cadherin-11 is mediated by PI3K/Akt pathway in synovial fibroblasts from temporomandibular joint. Wu M, et al. Osteoarthritis Cartilage, 2013 Oct. PMID 23916685
  3. Adhesion molecules of detrusor muscle cells are influenced by a hypercholesterolemic diet or bladder outlet obstruction in a Wistar rat model. Pontes-Júnior J, et al. BMC Urol, 2013 Oct 20. PMID 24139451, Free PMC Article
  4. Different regulation of N-cadherin and cadherin-11 in rat hippocampus. Bartelt-Kirbach B, et al. Cell Commun Adhes, 2010 Aug. PMID 21250828
  5. Loss of cadherin-11 adhesion receptor enhances plastic changes in hippocampal synapses and modifies behavioral responses. Manabe T, et al. Mol Cell Neurosci, 2000 Jun. PMID 10860580

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that estradiol mainly promoted cadherin-11 expression in M1-like macrophages of inflamed temporomandibular joint.
    Title: Estradiol promotes M1-like macrophage activation through cadherin-11 to aggravate temporomandibular joint inflammation in rats.
  2. Higher Cadherin-11 expression was observed only in the high choleserol diet-treated rats with bladder outlet obstruction.
    Title: Adhesion molecules of detrusor muscle cells are influenced by a hypercholesterolemic diet or bladder outlet obstruction in a Wistar rat model.
  3. The findings suggest that cadherin-11 may play an important role in synovial fibroblasts from the temporomandibular joint following exposure to mechanical loading and inflammatory stimulation.
    Title: Pressure and inflammatory stimulation induced increase of cadherin-11 is mediated by PI3K/Akt pathway in synovial fibroblasts from temporomandibular joint.
  4. Cadherin-11 expression is relatively low in early hippocampus, but high in mature synapses, at postnatal and adult stages. Cadherin-11 might be more important for stabilization of synapses in the postnatal period and adulthood.
    Title: Different regulation of N-cadherin and cadherin-11 in rat hippocampus.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables beta-catenin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in adherens junction organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in aortic valve formation ISO
Inferred from Sequence Orthology
more info
  
involved_in calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion ISO
Inferred from Sequence Orthology
more info
  
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell migration ISO
Inferred from Sequence Orthology
more info
  
involved_in cell morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell adhesion TAS
Traceable Author Statement
more info
 PubMed 
involved_in cell-cell adhesion mediated by cadherin IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-cell junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within corticospinal tract morphogenesis ISO
Inferred from Sequence Orthology
more info
  
involved_in focal adhesion assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in homophilic cell adhesion via plasma membrane adhesion molecules IEA
Inferred from Electronic Annotation
more info
  
involved_in modulation of chemical synaptic transmission ISO
Inferred from Sequence Orthology
more info
  
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Schaffer collateral - CA1 synapse ISO
Inferred from Sequence Orthology
more info
  
is_active_in adherens junction IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catenin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
cadherin-11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_053392.1 → NP_445844.1  cadherin-11 precursor

    See identical proteins and their annotated locations for NP_445844.1

    Status: VALIDATED

    Source sequence(s)
    JAXUCZ010000019
    UniProtKB/TrEMBL
    A6JXY0, F1MAH6
    Related
    ENSRNOP00000018535.3, ENSRNOT00000018535.6
    Conserved Domains (3) summary
    cd11304
    Location:163 → 264
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:649 → 787
    Cadherin_C; Cadherin cytoplasmic region

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086037.1 Reference GRCr8

    Range
    2152961..2312140
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063278319.1 → XP_063134389.1  cadherin-11 isoform X1

    UniProtKB/TrEMBL
    F1MAH6

  2. XM_006255059.5 → XP_006255121.1  cadherin-11 isoform X1

    See identical proteins and their annotated locations for XP_006255121.1

    UniProtKB/TrEMBL
    A6JXY0, F1MAH6
    Conserved Domains (3) summary
    cd11304
    Location:163 → 264
    Cadherin_repeat; Cadherin tandem repeat domain
    smart00112
    Location:79 → 157
    CA; Cadherin repeats
    pfam01049
    Location:649 → 787
    Cadherin_C; Cadherin cytoplasmic region
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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