U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRXL2A peroxiredoxin like 2A [ Homo sapiens (human) ]

Gene ID: 84293, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
PRXL2Aprovided by HGNC
Official Full Name
peroxiredoxin like 2Aprovided by HGNC
Primary source
HGNC:HGNC:28651
See related
Ensembl:ENSG00000122378 MIM:617165; AllianceGenome:HGNC:28651
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Adrx; PAMM; FAM213A; C10orf58
Summary
Enables antioxidant activity. Involved in regulation of osteoclast differentiation. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in fat (RPKM 75.6), brain (RPKM 14.4) and 16 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See PRXL2A in Genome Data Viewer
Location:
10q23.1
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (80407829..80437115)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (81276927..81306214)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (82167585..82196871)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 519 pseudogene 1 Neighboring gene MPRA-validated peak1026 silencer Neighboring gene DPY30 domain containing 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:82123032-82123216 Neighboring gene DPY30 domain containing 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:82163430-82163602 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2545 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82168661-82169254 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:82170101-82170600 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:82177040-82177582 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3654 Neighboring gene Sharpr-MPRA regulatory region 12974 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3655 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82214375-82214892 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3657 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3658 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3659 Neighboring gene Sharpr-MPRA regulatory region 907 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82224527-82225098 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82225099-82225670 Neighboring gene Sharpr-MPRA regulatory region 4556 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3660 Neighboring gene tetraspanin 14 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3661 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3662 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3663 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2547 Neighboring gene Sharpr-MPRA regulatory region 2609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:82257110-82258073 Neighboring gene Sharpr-MPRA regulatory region 10623 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3664 Neighboring gene uncharacterized LOC124902471 Neighboring gene TSPAN14 antisense RNA 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. FAM213A is linked to prognostic significance in acute myeloid leukemia through regulation of oxidative stress and myelopoiesis. Oh CK, et al. Hematol Oncol, 2020 Aug. PMID 32124993
  2. Adiporedoxin suppresses endothelial activation via inhibiting MAPK and NF-κB signaling. He H, et al. Sci Rep, 2016 Dec 12. PMID 27941911, Free PMC Article
  3. A short report: PAMM, a novel antioxidant protein, induced by oxidative stress. Xu Y, et al. Redox Biol, 2015 Dec. PMID 26402163, Free PMC Article
  4. miR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A. Chen YF, et al. Redox Biol, 2019 Apr. PMID 30785086, Free PMC Article
  5. Adiporedoxin, an upstream regulator of ER oxidative folding and protein secretion in adipocytes. Jedrychowski MP, et al. Mol Metab, 2015 Nov. PMID 26629401, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAM213A is linked to prognostic significance in acute myeloid leukemia through regulation of oxidative stress and myelopoiesis.
    Title: FAM213A is linked to prognostic significance in acute myeloid leukemia through regulation of oxidative stress and myelopoiesis.
  2. this study has pinpointed novel clues demonstrating that downregulation of miR-125b suppressor underlies upregulation of PRXL2A in OSCC, and this then protects the affected tumor cells from oxidative stress.
    Title: miR-125b suppresses oral oncogenicity by targeting the anti-oxidative gene PRXL2A.
  3. Antioxidant stress induces PAMM mRNA expression in human peripheral blood mononuclear cells .
    Title: A short report: PAMM, a novel antioxidant protein, induced by oxidative stress.
  4. results suggest that adipocyte-derived PAMM may suppress macrophage activation by inhibiting MAPK signalling pathway.
    Title: Adipocyte-derived PAMM suppresses macrophage inflammation by inhibiting MAPK signalling.
  5. The PAMM is a redox regulatory protein that modulates osteoclast differentiation in vitro. PAMM expression may affect bone resorption in vivo and help to maintain bone mass.
    Title: PAMM: a redox regulatory protein that modulates osteoclast differentiation.
  6. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC4248, FLJ12536, FLJ14952, FLJ44312

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables antioxidant activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables antioxidant activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of osteoclast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
peroxiredoxin-like 2A
Names
Adiporedoxin
UPF0765 protein C10orf58
family with sequence similarity 213 member A
peroxiredoxin (PRX)-like 2 activated in M-CSF stimulated monocytes
peroxiredoxin-like 2 activated in M-CSF stimulated monocytes
redox-regulatory protein FAM213A
redox-regulatory protein PAMM

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243778.2 → NP_001230707.1  peroxiredoxin-like 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001230707.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AA829725, AC021028, AL359195, BC005871
    Consensus CDS
    CCDS7368.1
    UniProtKB/Swiss-Prot
    B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
    Related
    ENSP00000361261.5, ENST00000372187.9
    Conserved Domains (1) summary
    cd02970
    Location:48 → 201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  2. NM_001243779.2 → NP_001230708.1  peroxiredoxin-like 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001230708.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1)
    Source sequence(s)
    AA829725, AC021028, AF305824, BC005871, BE742158
    Consensus CDS
    CCDS7368.1
    UniProtKB/Swiss-Prot
    B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
    Related
    ENSP00000361262.1, ENST00000372188.5
    Conserved Domains (1) summary
    cd02970
    Location:48 → 201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  3. NM_001243780.2 → NP_001230709.1  peroxiredoxin-like 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_001230709.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses an alternate splice site in the 5' UTR compared to variant 1. Variants 1, 2, 3 and 4 encode the same isoform (1).
    Source sequence(s)
    AA829725, AC021028, BC024308, DB494833
    Consensus CDS
    CCDS7368.1
    UniProtKB/Swiss-Prot
    B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
    Related
    ENSP00000478152.1, ENST00000615554.4
    Conserved Domains (1) summary
    cd02970
    Location:48 → 201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  4. NM_001243781.2 → NP_001230710.1  peroxiredoxin-like 2A isoform 2 precursor

    See identical proteins and their annotated locations for NP_001230710.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site and initiates translation at a downstream, in-frame start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AA829725, AC021028, AK075447, BC005871
    Consensus CDS
    CCDS58089.1
    UniProtKB/Swiss-Prot
    Q9BRX8
    Related
    ENSP00000361259.1, ENST00000372185.5
    Conserved Domains (1) summary
    cd02970
    Location:37 → 190
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  5. NM_001243782.2 → NP_001230711.1  peroxiredoxin-like 2A isoform 3 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, uses an alternate splice site and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (3) is shorter and has a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AA829725, AC021028, AL359195, BC005871, CN396006
    UniProtKB/Swiss-Prot
    Q9BRX8
    Conserved Domains (1) summary
    cd02970
    Location:44 → 197
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  6. NM_032333.5 → NP_115709.3  peroxiredoxin-like 2A isoform 1 precursor

    See identical proteins and their annotated locations for NP_115709.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2, 3 and 4 encode the same isoform.
    Source sequence(s)
    AA829725, AC021028, AI589570, AK074643, BC071938
    Consensus CDS
    CCDS7368.1
    UniProtKB/Swiss-Prot
    B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
    Related
    ENSP00000482445.1, ENST00000606162.6
    Conserved Domains (1) summary
    cd02970
    Location:48 → 201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    80407829..80437115
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011540266.3 → XP_011538568.1  peroxiredoxin-like 2A isoform X2

    See identical proteins and their annotated locations for XP_011538568.1

    UniProtKB/Swiss-Prot
    B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
    Conserved Domains (1) summary
    cd02970
    Location:48 → 201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  2. XM_017016775.2 → XP_016872264.1  peroxiredoxin-like 2A isoform X1

    Conserved Domains (1) summary
    cd02970
    Location:55 → 208
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

  3. XM_011540265.3 → XP_011538567.1  peroxiredoxin-like 2A isoform X2

    See identical proteins and their annotated locations for XP_011538567.1

    UniProtKB/Swiss-Prot
    B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
    Conserved Domains (1) summary
    cd02970
    Location:48 → 201
    PRX_like2; Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    81276927..81306214
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366927.1 → XP_054222902.1  peroxiredoxin-like 2A isoform X1

  2. XM_054366929.1 → XP_054222904.1  peroxiredoxin-like 2A isoform X2

    UniProtKB/Swiss-Prot
    B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8

  3. XM_054366928.1 → XP_054222903.1  peroxiredoxin-like 2A isoform X2

    UniProtKB/Swiss-Prot
    B2RD81, Q6UW08, Q8N2K3, Q8NBK9, Q96JR0, Q9BRX8
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BRX8.3 GenPept UniProtKB/Swiss-Prot:Q9BRX8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous