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ZNF282 zinc finger protein 282 [ Homo sapiens (human) ]

Gene ID: 8427, updated on 5-Mar-2024

Summary

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Official Symbol
ZNF282provided by HGNC
Official Full Name
zinc finger protein 282provided by HGNC
Primary source
HGNC:HGNC:13076
See related
Ensembl:ENSG00000170265 MIM:603397; AllianceGenome:HGNC:13076
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HUB1
Summary
Enables sequence-specific double-stranded DNA binding activity. Predicted to be involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in endometrium (RPKM 6.2), prostate (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

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See ZNF282 in Genome Data Viewer
Location:
7q36.1
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (149195546..149226243)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (150377373..150408083)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (148892638..148923334)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene zinc finger protein 398 Neighboring gene uncharacterized LOC107986856 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:148842175-148842748 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148842749-148843322 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148843323-148843896 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26809 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148844471-148845044 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18749 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18750 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148853225-148853792 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148853793-148854358 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:148854359-148854926 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26810 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26811 Neighboring gene centrosomal protein 83kDa pseudogene Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148892414-148892735 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18752 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26812 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:148900065-148900565 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:148906433-148907147 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:148916930-148917919 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:148923698-148923905 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr7:148930294-148931493 Neighboring gene Sharpr-MPRA regulatory region 80 Neighboring gene zinc finger protein 212 Neighboring gene uncharacterized LOC124901769 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18753 Neighboring gene zinc finger protein 783

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma. Yeo SY, et al. Oncotarget, 2014 Dec 15. PMID 25373738, Free PMC Article
  2. SUMOylation of ZFP282 potentiates its positive effect on estrogen signaling in breast tumorigenesis. Yu EJ, et al. Oncogene, 2013 Aug 29. PMID 22986521, Free PMC Article
  3. HUB1, a novel Krüppel type zinc finger protein, represses the human T cell leukemia virus type I long terminal repeat-mediated expression. Okumura K, et al. Nucleic Acids Res, 1997 Dec 15. PMID 9396811, Free PMC Article
  4. Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution. Cheng J, et al. Science, 2005 May 20. PMID 15790807
  5. Quantitative dissection and stoichiometry determination of the human SET1/MLL histone methyltransferase complexes. van Nuland R, et al. Mol Cell Biol, 2013 May. PMID 23508102, Free PMC Article

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ZNF282 is E2F1 co-activator involved in esophageal squamous cell carcinoma
    Title: ZNF282 (Zinc finger protein 282), a novel E2F1 co-activator, promotes esophageal squamous cell carcinoma.
  2. SUMOylation of ZFP282 potentiates its positive effect on estrogen signaling in breast tumorigenesis.
    Title: SUMOylation of ZFP282 potentiates its positive effect on estrogen signaling in breast tumorigenesis.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables sequence-specific double-stranded DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in negative regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 282
Names
HTLV-I U5 repressive element-binding protein 1
HTLV-I U5RE-binding protein 1
HUB-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303481.3 → NP_001290410.1  zinc finger protein 282 isoform 2

    See identical proteins and their annotated locations for NP_001290410.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 3' end compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AC004890, AK316282, BC041704, BC073805, D30612
    Consensus CDS
    CCDS78284.1
    UniProtKB/Swiss-Prot
    Q9UDV7
    UniProtKB/TrEMBL
    Q86YG2
    Related
    ENSP00000418840.1, ENST00000479907.1
    Conserved Domains (1) summary
    smart00349
    Location:198 → 260
    KRAB; krueppel associated box

  2. NM_003575.4 → NP_003566.1  zinc finger protein 282 isoform 1

    See identical proteins and their annotated locations for NP_003566.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC041704, BC073805, D30612
    Consensus CDS
    CCDS5895.1
    UniProtKB/Swiss-Prot
    B4DRI5, O43691, Q6DKK0, Q9UDV7
    UniProtKB/TrEMBL
    A0A090N8Y3
    Related
    ENSP00000477841.1, ENST00000610704.5
    Conserved Domains (6) summary
    cd07765
    Location:198 → 237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:198 → 260
    KRAB; krueppel associated box
    COG5048
    Location:506 → 651
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:548 → 568
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:574 → 596
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:616 → 641
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    149195546..149226243
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006716151.5 → XP_006716214.1  zinc finger protein 282 isoform X1

    Conserved Domains (6) summary
    cd07765
    Location:198 → 237
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:198 → 260
    KRAB; krueppel associated box
    COG5048
    Location:507 → 652
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:549 → 569
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:575 → 597
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:617 → 642
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    150377373..150408083
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054359217.1 → XP_054215192.1  zinc finger protein 282 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UDV7.3 GenPept UniProtKB/Swiss-Prot:Q9UDV7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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