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PSMG3 proteasome assembly chaperone 3 [ Homo sapiens (human) ]

Gene ID: 84262, updated on 5-Mar-2024

Summary

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Official Symbol
PSMG3provided by HGNC
Official Full Name
proteasome assembly chaperone 3provided by HGNC
Primary source
HGNC:HGNC:22420
See related
Ensembl:ENSG00000157778 MIM:617528; AllianceGenome:HGNC:22420
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAC3; C7orf48
Summary
Enables molecular adaptor activity. Involved in chaperone-mediated protein complex assembly. Predicted to be part of protein-containing complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 8.7), skin (RPKM 6.6) and 25 other tissues See more
Orthologs
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Genomic context

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Location:
7p22.3
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (1567332..1570032, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (1679436..1682138, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (1606968..1609668, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100128653 Neighboring gene Sharpr-MPRA regulatory region 13805 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1575241-1576184 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1576185-1577128 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1578073-1579015 Neighboring gene MAF bZIP transcription factor K Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25495 Neighboring gene transmembrane protein 184A Neighboring gene ReSE screen-validated silencer GRCh37_chr7:1594367-1594549 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1594659-1595459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1595460-1596259 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1599484-1599984 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:1599985-1600485 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:1606554-1607122 and GRCh37_chr7:1607123-1607691 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:1609398-1609966 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17861 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25497 Neighboring gene PSMG3 antisense RNA 1 (head to head) Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1615363-1616185 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:1616186-1617008 Neighboring gene uncharacterized LOC105375123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 25498

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Anaplasma phagocytophilum AptA enhances the UPS, autophagy, and anti-apoptosis of host cells by PSMG3. Ma Z, et al. Int J Biol Macromol, 2021 Aug 1. PMID 34126152
  2. Crystal structure of human proteasome assembly chaperone PAC4 involved in proteasome formation. Kurimoto E, et al. Protein Sci, 2017 May. PMID 28263418, Free PMC Article
  3. PAC1-PAC2 proteasome assembly chaperone retains the core α4-α7 assembly intermediates in the cytoplasm. Wu W, et al. Genes Cells, 2018 Oct. PMID 30133132
  4. Cooperation of multiple chaperones required for the assembly of mammalian 20S proteasomes. Hirano Y, et al. Mol Cell, 2006 Dec 28. PMID 17189198
  5. Affinity purification strategy to capture human endogenous proteasome complexes diversity and to identify proteasome-interacting proteins. Bousquet-Dubouch MP, et al. Mol Cell Proteomics, 2009 May. PMID 19193609, Free PMC Article

See all (30) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC10911

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular adaptor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chaperone-mediated protein complex assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteasome assembly IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
proteasome assembly chaperone 3
Names
PAC-3
hPAC3
proteasome (prosome, macropain) assembly chaperone 3
proteasome assembling chaperone 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001134340.2 → NP_001127812.1  proteasome assembly chaperone 3

    See identical proteins and their annotated locations for NP_001127812.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    BM825255, CN261807
    Consensus CDS
    CCDS5327.1
    UniProtKB/Swiss-Prot
    A4D216, A8MPW2, Q9BT73
    Related
    ENSP00000384799.3, ENST00000404674.7
    Conserved Domains (1) summary
    pfam10178
    Location:34 → 119
    PAC3; Proteasome assembly chaperone 3

  2. NM_032302.4 → NP_115678.1  proteasome assembly chaperone 3

    See identical proteins and their annotated locations for NP_115678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC093734, BC027171, CN261807
    Consensus CDS
    CCDS5327.1
    UniProtKB/Swiss-Prot
    A4D216, A8MPW2, Q9BT73
    Related
    ENSP00000288607.2, ENST00000288607.3
    Conserved Domains (1) summary
    pfam10178
    Location:34 → 119
    PAC3; Proteasome assembly chaperone 3

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    1567332..1570032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    1679436..1682138 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BT73.1 GenPept UniProtKB/Swiss-Prot:Q9BT73

Gene LinkOut

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