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IQCG IQ motif containing G [ Homo sapiens (human) ]

Gene ID: 84223, updated on 3-Apr-2024

Summary

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Official Symbol
IQCGprovided by HGNC
Official Full Name
IQ motif containing Gprovided by HGNC
Primary source
HGNC:HGNC:25251
See related
Ensembl:ENSG00000114473 MIM:612477; AllianceGenome:HGNC:25251
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DRC9; CFAP122
Summary
Enables Hsp70 protein binding activity and calmodulin binding activity. Predicted to be involved in sperm axoneme assembly. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in testis (RPKM 19.6), ovary (RPKM 6.1) and 20 other tissues See more
Orthologs
mouse all
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Genomic context

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Location:
3q29
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (197889077..197960177, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (200621536..200692632, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (197615948..197686862, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene leucine rich repeats and calponin homology domain containing 3 Neighboring gene uncharacterized LOC124909482 Neighboring gene uncharacterized LOC105374310 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21121 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:197581553-197582752 Neighboring gene ribosomal protein L17 pseudogene 18 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:197594026-197594561 Neighboring gene NUP98-IQCG recombination region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:197626412-197627184 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:197628168-197628668 Neighboring gene RNA, U6 small nuclear 858, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15094 Neighboring gene uncharacterized LOC124906330 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:197639502-197640701 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21122 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:197676763-197677545 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:197678329-197679110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:197685865-197686365 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15095 Neighboring gene MPRA-validated peak4998 silencer Neighboring gene ribosomal protein L35a Neighboring gene MPRA-validated peak4999 silencer Neighboring gene leishmanolysin like peptidase Neighboring gene RNA, U6 small nuclear 621, pseudogene Neighboring gene LMLN antisense RNA 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway. Pan MM, et al. Leukemia, 2016 Jul. PMID 26675333
  2. IQ motif-containing G (Iqcg) is required for mouse spermiogenesis. Harris TP, et al. G3 (Bethesda), 2014 Feb 19. PMID 24362311, Free PMC Article
  3. The N-DRC forms a conserved biochemical complex that maintains outer doublet alignment and limits microtubule sliding in motile axonemes. Bower R, et al. Mol Biol Cell, 2013 Apr. PMID 23427265, Free PMC Article
  4. Functional and molecular features of the calmodulin-interacting protein IQCG required for haematopoiesis in zebrafish. Chen LT, et al. Nat Commun, 2014 May 2. PMID 24787902
  5. A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition. Benslimane Y, et al. Aging Cell, 2021 Apr. PMID 33660365, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. human NUP98-IQCG fusion protein could induce fatal and transplantable acute myelomonocytic leukemia in a mouse model
    Title: Human NUP98-IQCG fusion protein induces acute myelomonocytic leukemia in mice by dysregulating the Hox/Pbx3 pathway.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ11667, FLJ23571, FLJ37775, DKFZp434B227

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables Hsp70 protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calmodulin binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in cilium organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sperm axoneme assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in actin cytoskeleton IDA
Inferred from Direct Assay
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in extracellular exosome HDA PubMed 
located_in manchette ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in sperm flagellum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
dynein regulatory complex protein 9
Names
IQ domain-containing protein G
dynein regulatory complex subunit 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033072.1 RefSeqGene

    Range
    5025..75939
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001134435.3 → NP_001127907.1  dynein regulatory complex protein 9 isoform a

    See identical proteins and their annotated locations for NP_001127907.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 3 encode the same isoform (a).
    Source sequence(s)
    AK027224, CR533515, DA566107
    Consensus CDS
    CCDS3331.1
    UniProtKB/Swiss-Prot
    Q9BST2, Q9H095, Q9HAG8
    UniProtKB/TrEMBL
    B9EG57
    Related
    ENSP00000407736.1, ENST00000455191.5
    Conserved Domains (2) summary
    smart00015
    Location:393 → 412
    IQ; Calmodulin-binding motif
    TIGR02169
    Location:179 → 396
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  2. NM_001323027.2 → NP_001309956.1  dynein regulatory complex protein 9 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 3 encode the same isoform (a).
    Source sequence(s)
    AC135893, BC004816
    Consensus CDS
    CCDS3331.1
    UniProtKB/Swiss-Prot
    Q9BST2, Q9H095, Q9HAG8
    UniProtKB/TrEMBL
    B9EG57
    Conserved Domains (2) summary
    smart00015
    Location:393 → 412
    IQ; Calmodulin-binding motif
    TIGR02169
    Location:179 → 396
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  3. NM_001323028.2 → NP_001309957.1  dynein regulatory complex protein 9 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC135893, BC004816
    UniProtKB/TrEMBL
    B9EG57
    Conserved Domains (2) summary
    PTZ00108
    Location:312 → 381
    PTZ00108; DNA topoisomerase 2-like protein; Provisional
    pfam04111
    Location:204 → 345
    APG6; Autophagy protein Apg6

  4. NM_001323029.2 → NP_001309958.1  dynein regulatory complex protein 9 isoform c

    Status: VALIDATED

    Source sequence(s)
    AC135893, BC004816
    UniProtKB/Swiss-Prot
    Q9H095
    Conserved Domains (1) summary
    TIGR02169
    Location:81 → 298
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  5. NM_001323030.2 → NP_001309959.1  dynein regulatory complex protein 9 isoform d

    Status: VALIDATED

    Source sequence(s)
    BC068973, DA566107
    Consensus CDS
    CCDS82898.1
    UniProtKB/TrEMBL
    C9JKX8
    Related
    ENSP00000389897.1, ENST00000453254.5

  6. NM_032263.5 → NP_115639.1  dynein regulatory complex protein 9 isoform a

    See identical proteins and their annotated locations for NP_115639.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1 through 3 encode the same isoform (a).
    Source sequence(s)
    AL136889, BC004816, BC016156, CK001737
    Consensus CDS
    CCDS3331.1
    UniProtKB/Swiss-Prot
    Q9BST2, Q9H095, Q9HAG8
    UniProtKB/TrEMBL
    B9EG57
    Related
    ENSP00000265239.6, ENST00000265239.11
    Conserved Domains (2) summary
    smart00015
    Location:393 → 412
    IQ; Calmodulin-binding motif
    TIGR02169
    Location:179 → 396
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    197889077..197960177 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024453790.2 → XP_024309558.1  dynein regulatory complex protein 9 isoform X1

    UniProtKB/Swiss-Prot
    Q9BST2, Q9H095, Q9HAG8
    UniProtKB/TrEMBL
    B9EG57
    Conserved Domains (2) summary
    smart00015
    Location:393 → 412
    IQ; Calmodulin-binding motif
    TIGR02169
    Location:179 → 396
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RNA

  1. XR_007095755.1 RNA Sequence

  2. XR_007095756.1 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    200621536..200692632 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054348086.1 → XP_054204061.1  dynein regulatory complex protein 9 isoform X1

    UniProtKB/Swiss-Prot
    Q9BST2, Q9H095, Q9HAG8

RNA

  1. XR_008486840.1 RNA Sequence

  2. XR_008486841.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9H095.1 GenPept UniProtKB/Swiss-Prot:Q9H095

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