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PPP1R1B protein phosphatase 1 regulatory inhibitor subunit 1B [ Homo sapiens (human) ]

Gene ID: 84152, updated on 3-Apr-2024

Summary

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Official Symbol
PPP1R1Bprovided by HGNC
Official Full Name
protein phosphatase 1 regulatory inhibitor subunit 1Bprovided by HGNC
Primary source
HGNC:HGNC:9287
See related
Ensembl:ENSG00000131771 MIM:604399; AllianceGenome:HGNC:9287
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DARPP32; DARPP-32
Summary
This gene encodes a bifunctional signal transduction molecule. Dopaminergic and glutamatergic receptor stimulation regulates its phosphorylation and function as a kinase or phosphatase inhibitor. As a target for dopamine, this gene may serve as a therapeutic target for neurologic and psychiatric disorders. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Biased expression in colon (RPKM 51.4), salivary gland (RPKM 45.0) and 11 other tissues See more
Orthologs
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Genomic context

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See PPP1R1B in Genome Data Viewer
Location:
17q12
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (39626707..39636624)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (40489777..40500194)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (37783205..37792877)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene neuronal differentiation 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12097 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12098 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8458 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8459 Neighboring gene VISTA enhancer hs627 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37775157-37775657 Neighboring gene uncharacterized LOC124903997 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12099 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37787615-37788534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37788535-37789454 Neighboring gene uncharacterized LOC124903998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37791542-37792165 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12100 Neighboring gene StAR related lipid transfer domain containing 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37810255-37810816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37814469-37815344 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:37822021-37822758 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:37822759-37823496 Neighboring gene titin-cap

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A Homozygous Missense Variant in PPP1R1B/DARPP-32 Is Associated With Generalized Complex Dystonia. Khan A, et al. Mov Disord, 2022 Feb. PMID 34820905
  2. Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression. Kotecha S, et al. Sci Rep, 2019 Nov 18. PMID 31740718, Free PMC Article
  3. Darpp-32 and t-Darpp protein products of PPP1R1B: Old dogs with new tricks. Avanes A, et al. Biochem Pharmacol, 2019 Feb. PMID 30552871, Free PMC Article
  4. Influence of DARPP-32 genetic variation on BOLD activation to happy faces. Persson N, et al. Soc Cogn Affect Neurosci, 2017 Oct 1. PMID 29048604, Free PMC Article
  5. Characterising the developmental profile of human embryonic stem cell-derived medium spiny neuron progenitors and assessing mature neuron function using a CRISPR-generated human DARPP-32(WT/eGFP-AMP) reporter line. Hunt CPJ, et al. Neurochem Int, 2017 Jun. PMID 28065797

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways.
    Title: Unravelling transcriptomic complexity in breast cancer through modulation of DARPP-32 expression and signalling pathways.
  2. DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium.
    Title: DARPP32, a target of hyperactive mTORC1 in the retinal pigment epithelium.
  3. A Homozygous Missense Variant in PPP1R1B/DARPP-32 Is Associated With Generalized Complex Dystonia.
    Title: A Homozygous Missense Variant in PPP1R1B/DARPP-32 Is Associated With Generalized Complex Dystonia.
  4. PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression.
    Title: PP1, PKA and DARPP-32 in breast cancer: A retrospective assessment of protein and mRNA expression.
  5. Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase-1 and cyclin-dependent kinase 5 expression in ovarian cancer.
    Title: Dopamine and cAMP-regulated phosphoprotein 32kDa (DARPP-32), protein phosphatase-1 and cyclin-dependent kinase 5 expression in ovarian cancer.
  6. ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation.
    Title: ASCL1-regulated DARPP-32 and t-DARPP stimulate small cell lung cancer growth and neuroendocrine tumour cell proliferation.
  7. Silencing of miR490-3p by H. pylori activates DARPP-32 and induces resistance to gefitinib.
    Title: Silencing of miR490-3p by H. pylori activates DARPP-32 and induces resistance to gefitinib.
  8. Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression.
    Title: Dopamine and cAMP-regulated phosphoprotein 32 kDa (DARPP-32) and survival in breast cancer: a retrospective analysis of protein and mRNA expression.
  9. Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder.
    Title: Differential protein expression of DARPP-32 versus Calcineurin in the prefrontal cortex and nucleus accumbens in schizophrenia and bipolar disorder.
  10. the DARPP-32-IGF1R signaling axis plays a key role in regulating the STAT3 signaling, a critical step in gastric tumorigenesis
    Title: Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells.
Submit: New GeneRIF Correction See all GeneRIFs (82)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ20940

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cAMP-dependent protein kinase inhibitor activity TAS
Traceable Author Statement
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein phosphatase inhibitor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein phosphatase inhibitor activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein phosphatase regulator activity TAS
Traceable Author Statement
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in behavioral response to cocaine IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular response to cocaine IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in locomotory behavior IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of female receptivity IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to amphetamine IEA
Inferred from Electronic Annotation
more info
  
involved_in response to morphine IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction TAS
Traceable Author Statement
more info
 PubMed 
involved_in visual learning IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
protein phosphatase 1 regulatory subunit 1B
Names
dopamine and cAMP-regulated neuronal phosphoprotein 32
NP_001229393.1
NP_115568.2
NP_852606.1
XP_016880705.1
XP_016880706.1
XP_054173515.1
XP_054173516.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030330.1 RefSeqGene

    Range
    5029..14701
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242464.2 → NP_001229393.1  protein phosphatase 1 regulatory subunit 1B isoform 2

    See identical proteins and their annotated locations for NP_001229393.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode isoform 2
    Source sequence(s)
    AF435973, AY070271
    Consensus CDS
    CCDS11340.1
    Related
    ENSP00000377808.1, ENST00000394265.5
    Conserved Domains (1) summary
    pfam05395
    Location:1 → 76
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

  2. NM_032192.4 → NP_115568.2  protein phosphatase 1 regulatory subunit 1B isoform 1

    See identical proteins and their annotated locations for NP_115568.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AF464196
    Consensus CDS
    CCDS11339.1
    UniProtKB/Swiss-Prot
    Q547V9, Q547W0, Q9H7G1, Q9UD71
    UniProtKB/TrEMBL
    B3KVQ9, J3KT77
    Related
    ENSP00000254079.4, ENST00000254079.9
    Conserved Domains (1) summary
    pfam05395
    Location:2 → 112
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

  3. NM_181505.4 → NP_852606.1  protein phosphatase 1 regulatory subunit 1B isoform 2

    See identical proteins and their annotated locations for NP_852606.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 3 encode isoform 2.
    Source sequence(s)
    AY070271
    Consensus CDS
    CCDS11340.1
    Related
    ENSP00000377810.2, ENST00000394267.2
    Conserved Domains (1) summary
    pfam05395
    Location:1 → 76
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

    Range
    39626707..39636624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017025216.3 → XP_016880705.1  protein phosphatase 1 regulatory subunit 1B isoform X1

    UniProtKB/Swiss-Prot
    Q547V9, Q547W0, Q9H7G1, Q9UD71
    UniProtKB/TrEMBL
    B3KVQ9, J3KT77
    Related
    ENSP00000462137.1, ENST00000580825.5
    Conserved Domains (1) summary
    pfam05395
    Location:2 → 112
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

  2. XM_017025217.3 → XP_016880706.1  protein phosphatase 1 regulatory subunit 1B isoform X2

    Conserved Domains (1) summary
    pfam05395
    Location:1 → 76
    DARPP-32; Protein phosphatase inhibitor 1/DARPP-32

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060941.1 Alternate T2T-CHM13v2.0

    Range
    40489777..40500194
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054317540.1 → XP_054173515.1  protein phosphatase 1 regulatory subunit 1B isoform X1

    UniProtKB/Swiss-Prot
    Q547V9, Q547W0, Q9H7G1, Q9UD71
    UniProtKB/TrEMBL
    B3KVQ9

  2. XM_054317541.1 → XP_054173516.1  protein phosphatase 1 regulatory subunit 1B isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UD71.2 GenPept UniProtKB/Swiss-Prot:Q9UD71

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