Sucnr1 succinate receptor 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sucnr1provided by MGI
Official Full Name: succinate receptor 1provided by MGI
Primary source: MGI:MGI:1934135
See related: Ensembl:ENSMUSG00000027762 AllianceGenome:MGI:1934135
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Gpr91
Summary: Enables signaling receptor activity. Acts upstream of or within several processes, including macrophage activation involved in immune response; regulation of angiotensin metabolic process; and renin secretion into blood stream. Predicted to be located in cell surface. Is expressed in neural retina and retina. Orthologous to human SUCNR1 (succinate receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in subcutaneous fat pad adult (RPKM 18.1), genital fat pad adult (RPKM 15.8) and 3 other tissues See more
Orthologs: human all
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Genomic context

Location:: 3 D; 3 29.17 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	3	NC_000069.7 (59989290..59994987)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	3	NC_000069.6 (60081869..60087566)

Chromosome 3 - NC_000069.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice.
Title: G-Protein-Coupled Receptor 91-Dependent Signalling Does Not Influence Vascular Inflammation and Atherosclerosis in Hyperlipidaemic Mice.
Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD.
Title: Protective effects of the succinate/SUCNR1 axis on damaged hepatocytes in NAFLD.
succinate-mediated GPR91 activation might be a potential therapeutic strategy for protecting cardiomyocytes from ischemic injury.
Title: Succinate induces aberrant mitochondrial fission in cardiomyocytes through GPR91 signaling.
this study shows that succinate receptor mediates intestinal inflammation and fibrosis
Title: Succinate receptor mediates intestinal inflammation and fibrosis.
Myeloid-specific deficiency in succinate receptor 1 (SUCNR1) promoted a local pro-inflammatory phenotype, disrupted glucose homeostasis and exacerbated the metabolic consequences of diet-induced obesity.
Title: SUCNR1 controls an anti-inflammatory program in macrophages to regulate the metabolic response to obesity.
GPR91 and GPR99 are expressed on axons of developing retinal ganglion cells (RGCs) and have complementary roles during RGC axon growth in an extracellular signal-regulated kinases 1 and 2 (ERK1/2)-dependent manner. However, they have no effects on axon guidance.
Title: Receptors of intermediates of carbohydrate metabolism, GPR91 and GPR99, mediate axon growth.
Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1.
Title: Succinate accumulation impairs cardiac pyruvate dehydrogenase activity through GRP91-dependent and independent signaling pathways: Therapeutic effects of ginsenoside Rb1.
Succinate functions as an extracellular ligand through binding to its specific receptor on osteoclastic lineage cells and stimulates osteoclastogenesis in vitro and in vivo. Strategies inhibiting Sucnr1 activation inhibit osteoclastogenesis.
Title: Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis.
activation of SUCNR1 in macrophages is important for both infiltration and inflammation of adipose tissue in obesity
Title: SUCNR1-mediated chemotaxis of macrophages aggravates obesity-induced inflammation and diabetes.
This study shows that metformin can attenuate activation of HSCs by activating the AMPK pathway and inhibiting the succinate-GPR91 pathway. Metformin has therapeutic potential for treating steatohepatitis and liver fibrosis.
Title: Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition.

Submit: New GeneRIF Correction See all GeneRIFs (18)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (6) 1 citation
Endonuclease-mediated (6) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables G protein-coupled receptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables signaling receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in G protein-coupled receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within interleukin-1 beta production	ISO Inferred from Sequence Orthology more info	PubMed
acts_upstream_of_or_within macrophage activation involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of angiotensin metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within renin secretion into blood stream	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cell surface	TAS Traceable Author Statement more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: succinate receptor 1

Names: G protein-coupled receptor 91

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.