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Pi4k2a phosphatidylinositol 4-kinase type 2 alpha [ Mus musculus (house mouse) ]

Gene ID: 84095, updated on 11-Apr-2024

Summary

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Official Symbol
Pi4k2aprovided by MGI
Official Full Name
phosphatidylinositol 4-kinase type 2 alphaprovided by MGI
Primary source
MGI:MGI:1934031
See related
Ensembl:ENSMUSG00000025178 AllianceGenome:MGI:1934031
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pi4k2
Summary
Predicted to enable 1-phosphatidylinositol 4-kinase activity; AP-3 adaptor complex binding activity; and ATP binding activity. Predicted to be involved in several processes, including basophil degranulation; endosome organization; and phosphatidylinositol phosphate biosynthetic process. Predicted to act upstream of or within phosphorylation. Located in several cellular components, including dendrite; neuronal cell body; and presynaptic membrane. Is expressed in several structures, including alimentary system; integumental system; nervous system; respiratory system; and sensory organ. Orthologous to human PI4K2A (phosphatidylinositol 4-kinase type 2 alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 22.2), adrenal adult (RPKM 20.3) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Pi4k2a in Genome Data Viewer
Location:
19 C3; 19 35.74 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (42078590..42110657)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (42090148..42122218)

Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4933411K16 gene Neighboring gene 4-hydroxy-2-oxoglutarate aldolase 1 Neighboring gene MORN repeat containing 4 Neighboring gene STARR-seq mESC enhancer starr_46172 Neighboring gene STARR-positive B cell enhancer ABC_E781 Neighboring gene STARR-seq mESC enhancer starr_46173 Neighboring gene STARR-seq mESC enhancer starr_46176 Neighboring gene arginine vasopressin-induced 1 Neighboring gene STARR-seq mESC enhancer starr_46177 Neighboring gene STARR-seq mESC enhancer starr_46178 Neighboring gene STARR-positive B cell enhancer ABC_E5702 Neighboring gene MARVEL (membrane-associating) domain containing 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Phosphatidylinositol 4-kinase type IIalpha is targeted specifically to cellugyrin-positive glucose transporter 4 vesicles. Xu Z, et al. Mol Endocrinol, 2006 Nov. PMID 16772528
  2. PI4KIIα phosphorylation by GSK3 directs vesicular trafficking to lysosomes. Robinson JW, et al. Biochem J, 2014 Nov 15. PMID 25083612
  3. Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles. Salazar G, et al. Mol Biol Cell, 2005 Aug. PMID 15944223, Free PMC Article
  4. Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation. Khundadze M, et al. Autophagy, 2021 Nov. PMID 33618608, Free PMC Article
  5. Loss of phosphatidylinositol 4-kinase 2alpha activity causes late onset degeneration of spinal cord axons. Simons JP, et al. Proc Natl Acad Sci U S A, 2009 Jul 14. PMID 19581584, Free PMC Article

See all (37) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation.
    Title: Mouse models for hereditary spastic paraplegia uncover a role of PI4K2A in autophagic lysosome reformation.
  2. Itch directly associates with and ubiquitinates PI4KIIalpha, and both proteins colocalize on endosomes containing Wnt-activated frizzled 4 (Fz4) receptor
    Title: Phosphatidylinositol 4-kinase IIα function at endosomes is regulated by the ubiquitin ligase Itch.
  3. PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation.
    Title: PI4KIIalpha is a novel regulator of tumor growth by its action on angiogenesis and HIF-1alpha regulation.
  4. AP-3 and BLOC-1 act, either in concert or sequentially, to specify sorting of PI4KIIalpha along the endocytic route.
    Title: Hermansky-Pudlak syndrome protein complexes associate with phosphatidylinositol 4-kinase type II alpha in neuronal and non-neuronal cells.
  5. The unique N terminus of PI4K type IIalpha is required for the targeting of the enzyme to cellugyrin-positive vesicles.
    Title: Phosphatidylinositol 4-kinase type IIalpha is targeted specifically to cellugyrin-positive glucose transporter 4 vesicles.
  6. PI4KIIalpha is present on adaptor protein (AP) -3 organelles where it regulates AP-3 function
    Title: Phosphatidylinositol-4-kinase type II alpha is a component of adaptor protein-3-derived vesicles.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (2) 
  • Endonuclease-mediated (1) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC37783, MGC118011

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 1-phosphatidylinositol 4-kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables 1-phosphatidylinositol 4-kinase activity ISO
Inferred from Sequence Orthology
more info
  
enables AP-3 adaptor complex binding ISO
Inferred from Sequence Orthology
more info
  
enables ATP binding ISO
Inferred from Sequence Orthology
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in basophil degranulation ISO
Inferred from Sequence Orthology
more info
  
involved_in endosome organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol phosphate biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of BLOC-1 complex ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome ISO
Inferred from Sequence Orthology
more info
  
located_in exocytic vesicle ISO
Inferred from Sequence Orthology
more info
  
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in growing cell tip ISO
Inferred from Sequence Orthology
more info
  
located_in membrane ISO
Inferred from Sequence Orthology
more info
  
located_in membrane raft ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
  
located_in perikaryon ISO
Inferred from Sequence Orthology
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in presynaptic active zone IDA
Inferred from Direct Assay
more info
 PubMed 
located_in presynaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in trans-Golgi network IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
phosphatidylinositol 4-kinase type 2-alpha
Names
phosphatidylinositol 4-kinase type II-alpha
NP_663476.1
XP_011245707.1
XP_011245708.1
XP_036017627.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145501.2 → NP_663476.1  phosphatidylinositol 4-kinase type 2-alpha

    See identical proteins and their annotated locations for NP_663476.1

    Status: VALIDATED

    Source sequence(s)
    AC133503, AK030725, BY732177
    Consensus CDS
    CCDS29821.1
    UniProtKB/Swiss-Prot
    Q2TBE6
    Related
    ENSMUSP00000069284.5, ENSMUST00000066778.6
    Conserved Domains (1) summary
    pfam00454
    Location:133 → 429
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000085.7 Reference GRCm39 C57BL/6J

    Range
    42078590..42110657
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036161734.1 → XP_036017627.1  phosphatidylinositol 4-kinase type 2-alpha isoform X3

    UniProtKB/TrEMBL
    A0A494BBQ4
    Conserved Domains (1) summary
    pfam00454
    Location:133 → 317
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

  2. XM_011247406.4 → XP_011245708.1  phosphatidylinositol 4-kinase type 2-alpha isoform X2

    Conserved Domains (1) summary
    pfam00454
    Location:133 → 406
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase

  3. XM_011247405.4 → XP_011245707.1  phosphatidylinositol 4-kinase type 2-alpha isoform X1

    See identical proteins and their annotated locations for XP_011245707.1

    UniProtKB/Swiss-Prot
    Q2TBE6
    Related
    ENSMUSP00000158574.2, ENSMUST00000235932.2
    Conserved Domains (1) summary
    pfam00454
    Location:133 → 429
    PI3_PI4_kinase; Phosphatidylinositol 3- and 4-kinase
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2TBE6.1 GenPept UniProtKB/Swiss-Prot:Q2TBE6

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