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Plvap plasmalemma vesicle associated protein [ Mus musculus (house mouse) ]

Gene ID: 84094, updated on 21-Apr-2024

Summary

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Official Symbol
Plvapprovided by MGI
Official Full Name
plasmalemma vesicle associated proteinprovided by MGI
Primary source
MGI:MGI:1890497
See related
Ensembl:ENSMUSG00000034845 AllianceGenome:MGI:1890497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pv1; MECA32
Summary
Predicted to enable identical protein binding activity. Involved in developmental process and positive regulation of cellular extravasation. Predicted to be located in cell surface. Predicted to be integral component of membrane. Predicted to be active in caveola. Is expressed in several structures, including cardiovascular system; genitourinary system; liver; spleen; and trophectoderm. Human ortholog(s) of this gene implicated in congenital diarrhea. Orthologous to human PLVAP (plasmalemma vesicle associated protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in lung adult (RPKM 563.9), adrenal adult (RPKM 272.0) and 12 other tissues See more
Orthologs
human all
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Genomic context

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Location:
8 B3.3; 8 34.43 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71950397..71964446, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71497753..71511806, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E358 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene anoctamin 8 Neighboring gene STARR-positive B cell enhancer ABC_E2868 Neighboring gene GTP binding protein 3 Neighboring gene coiled-coil domain containing 194 Neighboring gene 14-3-3 protein sigma-like Neighboring gene STARR-seq mESC enhancer starr_21821 Neighboring gene STARR-positive B cell enhancer ABC_E1759 Neighboring gene bone marrow stromal cell antigen 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. A Potential New Role for Zinc in Age-Related Macular Degeneration through Regulation of Endothelial Fenestration. Cunningham F, et al. Int J Mol Sci, 2021 Nov 5. PMID 34769404, Free PMC Article
  2. PV1 in Caveolae Controls Lung Endothelial Permeability. Jones JH, et al. Am J Respir Cell Mol Biol, 2020 Oct. PMID 32663411, Free PMC Article
  3. Endothelial Plasmalemma Vesicle-Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells. Elgueta R, et al. J Immunol, 2016 Nov 15. PMID 27742829, Free PMC Article
  4. The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes. Rantakari P, et al. Nat Immunol, 2015 Apr. PMID 25665101
  5. Formation of fenestrae in murine liver sinusoids depends on plasmalemma vesicle-associated protein and is required for lipoprotein passage. Herrnberger L, et al. PLoS One, 2014. PMID 25541982, Free PMC Article

See all (81) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression analysis of plvap in mouse heart development, homeostasis and injury.
    Title: Expression analysis of plvap in mouse heart development, homeostasis and injury.
  2. A Potential New Role for Zinc in Age-Related Macular Degeneration through Regulation of Endothelial Fenestration.
    Title: A Potential New Role for Zinc in Age-Related Macular Degeneration through Regulation of Endothelial Fenestration.
  3. PV1 in Caveolae Controls Lung Endothelial Permeability.
    Title: PV1 in Caveolae Controls Lung Endothelial Permeability.
  4. Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated.
    Title: Fenestral diaphragms and PLVAP associations in liver sinusoidal endothelial cells are developmentally regulated.
  5. Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP.
    Title: Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP.
  6. These results show that Plvap expression in endothelial cells is important in the maintenance of IgM(+) B cells in the spleen and peritoneal cavity.
    Title: Endothelial Plasmalemma Vesicle-Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells.
  7. an endothelium-specific molecule, plasmalemma vesicle-associated protein (PLVAP), regulates the seeding of fetal monocyte-derived macrophages to tissues in mice
    Title: Fetal liver endothelium regulates the seeding of tissue-resident macrophages.
  8. Results indicate that PLVAP is not only required for the formation of endothelial diaphragms, but also for the formation of endothelial fenestrae, even of those without diaphragms.
    Title: Formation of fenestrae in murine liver sinusoids depends on plasmalemma vesicle-associated protein and is required for lipoprotein passage.
  9. In the lymphatic sinus, PLVAP forms a physical sieve that regulates the parenchymal entry of lymphocytes and soluble antigens.
    Title: The endothelial protein PLVAP in lymphatics controls the entry of lymphocytes and antigens into lymph nodes.
  10. PV1 is involved in the tumor angiogenesis
    Title: PV1 down-regulation via shRNA inhibits the growth of pancreatic adenocarcinoma xenografts.
Submit: New GeneRIF Correction See all GeneRIFs (15)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in MAPK cascade ISO
Inferred from Sequence Orthology
more info
  
involved_in developmental process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cellular extravasation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cellular extravasation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cellular extravasation ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of vascular permeability IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tumor necrosis factor-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
colocalizes_with caveola ISO
Inferred from Sequence Orthology
more info
  
located_in caveola ISO
Inferred from Sequence Orthology
more info
  
located_in cell surface ISO
Inferred from Sequence Orthology
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
plasmalemma vesicle-associated protein
Names
MECA-32 antigen
plasmalemma vesicle protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032398.2 → NP_115774.2  plasmalemma vesicle-associated protein

    See identical proteins and their annotated locations for NP_115774.2

    Status: VALIDATED

    Source sequence(s)
    AC127416, AF348403, AI225679, AV003733, BM898788
    Consensus CDS
    CCDS22396.1
    UniProtKB/Swiss-Prot
    Q91VC4, Q99JB1
    UniProtKB/TrEMBL
    G3X924
    Related
    ENSMUSP00000035404.5, ENSMUST00000048452.6
    Conserved Domains (1) summary
    pfam06637
    Location:1 → 436
    PV-1; PV-1 protein (PLVAP)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    71950397..71964446 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011242342.3 → XP_011240644.1  plasmalemma vesicle-associated protein isoform X1

    UniProtKB/Swiss-Prot
    Q91VC4, Q99JB1
    Conserved Domains (1) summary
    pfam06637
    Location:1 → 405
    PV-1; PV-1 protein (PLVAP)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q91VC4.1 GenPept UniProtKB/Swiss-Prot:Q91VC4

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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