U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TAGLN2 transgelin 2 [ Homo sapiens (human) ]

Gene ID: 8407, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TAGLN2provided by HGNC
Official Full Name
transgelin 2provided by HGNC
Primary source
HGNC:HGNC:11554
See related
Ensembl:ENSG00000158710 MIM:604634; AllianceGenome:HGNC:11554
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HA1756
Summary
The protein encoded by this gene is similar to the protein transgelin, which is one of the earliest markers of differentiated smooth muscle. The specific function of this protein has not yet been determined, although it is thought to be a tumor suppressor. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2013]
Expression
Ubiquitous expression in lung (RPKM 268.8), stomach (RPKM 231.0) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
1q23.2
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (159918111..159925507, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (159055181..159062575, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (159887901..159895297, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene cilia and flagella associated protein 45 Neighboring gene uncharacterized LOC124904435 Neighboring gene microRNA 4259 Neighboring gene Sharpr-MPRA regulatory regions 3039 and 8536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159882219-159882720 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:159887707-159888596 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1906 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1907 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1908 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1909 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1910 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1911 Neighboring gene uncharacterized LOC124904437 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:159893727-159894926 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:159904768-159905268 Neighboring gene immunoglobulin superfamily member 9 Neighboring gene uncharacterized LOC124904438 Neighboring gene Sharpr-MPRA regulatory region 11999 Neighboring gene SLAM family member 9 Neighboring gene long intergenic non-protein coding RNA 1133 Neighboring gene Fc receptor like 6 pseudogene 1

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TAGLN2 promotes papillary thyroid carcinoma invasion via the Rap1/PI3K/AKT axis. Wang L, et al. Endocr Relat Cancer, 2023 Jan 1. PMID 36222755
  2. Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients. Szelenberger R, et al. Int J Mol Sci, 2022 Jun 6. PMID 35683019, Free PMC Article
  3. Mechanisms of Transgelin-2 in Tumorigenesis. Zeng C, et al. Discov Med, 2021 Jul-Aug. PMID 35219353
  4. Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment? Woziwodzka K, et al. Molecules, 2021 Dec 23. PMID 35011306, Free PMC Article
  5. Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis. Wang Y, et al. Nutr Cancer, 2022. PMID 34498538

See all (154) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer.
    Title: Single-cell RNA sequencing reveals the lineage of malignant epithelial cells and upregulation of TAGLN2 promotes peritoneal metastasis in gastric cancer.
  2. TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
    Title: TAGLN2 Promotes the Proliferation, Migration, Invasion, and EMT of Clear Cell Renal Cell Carcinoma Through the PI3K/Akt Signaling Pathway.
  3. TAGLN2 promotes papillary thyroid carcinoma invasion via the Rap1/PI3K/AKT axis.
    Title: TAGLN2 promotes papillary thyroid carcinoma invasion via the Rap1/PI3K/AKT axis.
  4. Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients.
    Title: Variations in Blood Platelet Proteome and Transcriptome Revealed Altered Expression of Transgelin-2 in Acute Coronary Syndrome Patients.
  5. Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis.
    Title: Quercetin Antagonizes Esophagus Cancer by Modulating miR-1-3p/TAGLN2 Pathway-Dependent Growth and Metastasis.
  6. Mechanisms of Transgelin-2 in Tumorigenesis.
    Title: Mechanisms of Transgelin-2 in Tumorigenesis.
  7. Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.
    Title: Transgelin-2 interacts with CD44 to regulate Notch1 signaling pathway and participates in colorectal cancer proliferation and migration.
  8. Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?
    Title: Transgelin-2 in Multiple Myeloma: A New Marker of Renal Impairment?
  9. Transgelin-2 and phosphoregulation of the LIC2 subunit of dynein govern mitotic spindle orientation.
    Title: Transgelin-2 and phosphoregulation of the LIC2 subunit of dynein govern mitotic spindle orientation.
  10. Transgelin-2 contributes to proliferation and progression of hepatocellular carcinoma via regulating Annexin A2.
    Title: Transgelin-2 contributes to proliferation and progression of hepatocellular carcinoma via regulating Annexin A2.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

HIV-1 interactions

Go to the top of the page Help

Replication interactions

Interaction Pubs
Knockdown of transgelin 2 (TAGLN2) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 upregulates the expression of transgelin-2 in umbilical cord blood mononuclear cells PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of transgelin 2 (TAGLN2) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • KIAA0120

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cadherin binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in epithelial cell differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
is_active_in actin cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol TAS
Traceable Author Statement
more info
  
located_in extracellular exosome HDA PubMed 
located_in extracellular region TAS
Traceable Author Statement
more info
  
located_in vesicle HDA PubMed 

General protein information

Go to the top of the page Help
Preferred Names
transgelin-2
Names
SM22-alpha homolog
epididymis secretory sperm binding protein
epididymis tissue protein Li 7e

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001277223.2 → NP_001264152.1  transgelin-2 isoform b

    See identical proteins and their annotated locations for NP_001264152.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate first exon and begins translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AI270594, AK291562, AL513485, CF128621
    Consensus CDS
    CCDS1189.1
    UniProtKB/Swiss-Prot
    E9KL39, P37802, Q5JRQ6, Q5JRQ7, Q6FGI1, Q9BUH5, Q9H4P0
    UniProtKB/TrEMBL
    A0A384MTL2, X6RJP6
    Related
    ENSP00000357075.1, ENST00000320307.8
    Conserved Domains (2) summary
    pfam00402
    Location:174 → 198
    Calponin; Calponin family repeat
    cd21280
    Location:18 → 154
    CH_TAGLN2; calponin homology (CH) domain found in transgelin-2

  2. NM_001277224.2 → NP_001264153.1  transgelin-2 isoform a

    See identical proteins and their annotated locations for NP_001264153.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a).
    Source sequence(s)
    AL513485, AY007127
    Consensus CDS
    CCDS60314.1
    UniProtKB/TrEMBL
    X6RJP6
    Related
    ENSP00000357076.1, ENST00000368096.5
    Conserved Domains (2) summary
    pfam00307
    Location:47 → 154
    CH; Calponin homology (CH) domain
    pfam00402
    Location:195 → 218
    Calponin; Calponin family repeat

  3. NM_003564.3 → NP_003555.1  transgelin-2 isoform b

    See identical proteins and their annotated locations for NP_003555.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate first exon and begins translation at a downstream AUG compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a. Variants 2 and 3 both encode the same isoform (b).
    Source sequence(s)
    AI270594, AK291562
    Consensus CDS
    CCDS1189.1
    UniProtKB/Swiss-Prot
    E9KL39, P37802, Q5JRQ6, Q5JRQ7, Q6FGI1, Q9BUH5, Q9H4P0
    UniProtKB/TrEMBL
    A0A384MTL2, X6RJP6
    Related
    ENSP00000357077.5, ENST00000368097.9
    Conserved Domains (2) summary
    pfam00402
    Location:174 → 198
    Calponin; Calponin family repeat
    cd21280
    Location:18 → 154
    CH_TAGLN2; calponin homology (CH) domain found in transgelin-2

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    159918111..159925507 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    159055181..159062575 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P37802.3 GenPept UniProtKB/Swiss-Prot:P37802

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous