U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TSSK1B testis specific serine kinase 1B [ Homo sapiens (human) ]

Gene ID: 83942, updated on 5-Mar-2024

Summary

Go to the top of the page Help
Official Symbol
TSSK1Bprovided by HGNC
Official Full Name
testis specific serine kinase 1Bprovided by HGNC
Primary source
HGNC:HGNC:14968
See related
Ensembl:ENSG00000212122 MIM:610709; AllianceGenome:HGNC:14968
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TSK1; TSSK1; FKSG81; SPOGA4; STK22D
Summary
TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
Location:
5q22.2
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (113432553..113434989, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (113945250..113947686, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (112768250..112770686, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:112312161-112312920 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:112317139-112317674 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:112369970-112370528 Neighboring gene decapping mRNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:112379403-112379941 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:112404856-112405632 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:112405633-112406407 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:112409037-112409538 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:112416605-112417526 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:112417522-112418721 Neighboring gene MCC regulator of WNT signaling pathway Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:112454694-112455201 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:112502443-112503642 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:112538908-112539449 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr5:112571092-112572066 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:112580307-112581082 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16242 Neighboring gene uncharacterized LOC124901045 Neighboring gene MPRA-validated peak5422 silencer Neighboring gene uncharacterized LOC107986366 Neighboring gene Sharpr-MPRA regulatory region 13961 Neighboring gene RNA, U4atac small nuclear 13, pseudogene Neighboring gene uncharacterized LOC124901046 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22921 Neighboring gene H3K27ac hESC enhancer GRCh37_chr5:112849193-112849694

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Role of testis‑specific serine kinase 1B in undiagnosed male infertility. Kadiyska T, et al. Mol Med Rep, 2022 Jun. PMID 35485285, Free PMC Article
  2. Identification of peptide substrate and small molecule inhibitors of testis-specific serine/threonine kinase1 (TSSK1) by the developed assays. Zhang L, et al. J Med Chem, 2009 Jul 23. PMID 19530700
  3. Evolution of testis-specific kinases TSSK1B and TSSK2 in primates. Shang P, et al. Andrology, 2013 Jan. PMID 23258646
  4. Direct kinase-to-kinase signaling mediated by the FHA phosphoprotein recognition domain of the Dun1 DNA damage checkpoint kinase. Bashkirov VI, et al. Mol Cell Biol, 2003 Feb. PMID 12556502, Free PMC Article
  5. Expression analysis of the human testis-specific serine/threonine kinase (TSSK) homologues. A TSSK member is present in the equatorial segment of human sperm. Hao Z, et al. Mol Hum Reprod, 2004 Jun. PMID 15044604

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Role of testisspecific serine kinase 1B in undiagnosed male infertility.
    Title: Role of testis‑specific serine kinase 1B in undiagnosed male infertility.
  2. Report evolution of testis-specific kinases TSSK1B and TSSK2 in primates.
    Title: Evolution of testis-specific kinases TSSK1B and TSSK2 in primates.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables magnesium ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in spermatid development ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

Go to the top of the page Help
Preferred Names
testis-specific serine/threonine-protein kinase 1
Names
TSK-1
TSSK-1
serine/threonine kinase 22D (spermiogenesis associated)
serine/threonine kinase FKSG81
serine/threonine-protein kinase 22A
spermiogenesis associated 4
testis tissue sperm-binding protein Li 55e
testis-specific kinase 1
testis-specific serine kinase 1
NP_114417.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_032028.4 → NP_114417.1  testis-specific serine/threonine-protein kinase 1

    See identical proteins and their annotated locations for NP_114417.1

    Status: VALIDATED

    Source sequence(s)
    AC010431, AK122904, BC022515, DB025324, DB527624
    Consensus CDS
    CCDS4112.1
    UniProtKB/Swiss-Prot
    B2R8D9, Q9BXA7
    UniProtKB/TrEMBL
    A0ZT98
    Related
    ENSP00000375081.3, ENST00000390666.4
    Conserved Domains (1) summary
    cd14165
    Location:10 → 272
    STKc_TSSK1_2-like; Catalytic domain of testis-specific serine/threonine kinase 1, TSSK2, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    113432553..113434989 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    113945250..113947686 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BXA7.1 GenPept UniProtKB/Swiss-Prot:Q9BXA7

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous