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PRSS27 serine protease 27 [ Homo sapiens (human) ]

Gene ID: 83886, updated on 5-Mar-2024

Summary

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Official Symbol
PRSS27provided by HGNC
Official Full Name
serine protease 27provided by HGNC
Primary source
HGNC:HGNC:15475
See related
Ensembl:ENSG00000172382 MIM:608018; AllianceGenome:HGNC:15475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MPN; CAPH2
Summary
This gene is located within a large protease gene cluster on chromosome 16. It belongs to the group-1 subfamily of serine proteases. The encoded protein is a secreted tryptic serine protease and is expressed mainly in the pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Expression
Biased expression in esophagus (RPKM 55.3) and skin (RPKM 0.9) See more
Orthologs
all
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Genomic context

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See PRSS27 in Genome Data Viewer
Location:
16p13.3
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2712422..2720224, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2732636..2740438, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2762423..2770225, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene endogenous retrovirus group K13 member 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7063 Neighboring gene uncharacterized LOC124903627 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7065 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:2732882-2733492 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10278 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2738809-2739397 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2742501-2743319 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2743320-2744137 Neighboring gene potassium channel tetramerization domain containing 5 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7067 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7066 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7068 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2770495-2771062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7070 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:2772439-2772608 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2788581-2789158 Neighboring gene SRRM2 antisense RNA 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancers GRCh37_chr16:2801519-2802361 and GRCh37_chr16:2802362-2803204 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2803205-2804047 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr16:2807529-2808728 Neighboring gene serine/arginine repetitive matrix 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2819013-2819715 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2819716-2820419 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:2820420-2821122

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Expression Status of Serine Protease 27: A Prognostic Marker for Esophageal Squamous Cell Carcinoma Treated with Preoperative Chemotherapy/Chemoradiotherapy. Kataoka A, et al. Ann Surg Oncol, 2021 Sep. PMID 33452606
  2. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors. Raman K, et al. J Biol Chem, 2013 Apr 12. PMID 23447538, Free PMC Article
  3. The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds. Li W, et al. J Biol Chem, 2009 Jan 2. PMID 18948266
  4. Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas. Bhagwandin VJ, et al. J Biol Chem, 2003 Jan 31. PMID 12441343
  5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. Clark HF, et al. Genome Res, 2003 Oct. PMID 12975309, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Expression Status of Serine Protease 27: A Prognostic Marker for Esophageal Squamous Cell Carcinoma Treated with Preoperative Chemotherapy/Chemoradiotherapy.
    Title: Expression Status of Serine Protease 27: A Prognostic Marker for Esophageal Squamous Cell Carcinoma Treated with Preoperative Chemotherapy/Chemoradiotherapy.
  2. Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.
    Title: Mutational tail loss is an evolutionary mechanism for liberating marapsins and other type I serine proteases from transmembrane anchors.
  3. Marapsin's restricted expression, localization, and cytokine-inducible expression suggest a role in the terminal differentiation of keratinocytes in hyperproliferating squamous epithelia.
    Title: The serine protease marapsin is expressed in stratified squamous epithelia and is up-regulated in the hyperproliferative epidermis of psoriasis and regenerating wounds.
  4. structure and activity of the human enzyme, a serine peptidase found in the pancreas
    Title: Structure and activity of human pancreasin, a novel tryptic serine peptidase expressed primarily by the pancreas.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ44546

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine protease 27
Names
channel-activating protease 2
marapsin
pancreasin
protease, serine 27

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001318395.2 → NP_001305324.1  serine protease 27 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. It encodes isoform 2, which lacks a portion of the N-terminus and is shorter, compared to isoform 1.
    Source sequence(s)
    AY359106, BC036912
    UniProtKB/Swiss-Prot
    Q9BQR3
    Conserved Domains (2) summary
    smart00020
    Location:4 → 170
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:4 → 173
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

  2. NM_031948.5 → NP_114154.1  serine protease 27 isoform 1 precursor

    See identical proteins and their annotated locations for NP_114154.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC034294, BC036912
    Consensus CDS
    CCDS10476.1
    UniProtKB/Swiss-Prot
    Q9BQR3
    Related
    ENSP00000306390.3, ENST00000302641.8
    Conserved Domains (2) summary
    smart00020
    Location:34 → 272
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:36 → 275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2712422..2720224 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522689.3 → XP_011520991.1  serine protease 27 isoform X1

    See identical proteins and their annotated locations for XP_011520991.1

    Conserved Domains (2) summary
    smart00020
    Location:4 → 170
    Tryp_SPc; Trypsin-like serine protease
    cd00190
    Location:4 → 173
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2732636..2740438 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054314108.1 → XP_054170083.1  serine protease 27 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BQR3.1 GenPept UniProtKB/Swiss-Prot:Q9BQR3

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