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CDCA7 cell division cycle associated 7 [ Homo sapiens (human) ]

Gene ID: 83879, updated on 5-Mar-2024

Summary

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Official Symbol
CDCA7provided by HGNC
Official Full Name
cell division cycle associated 7provided by HGNC
Primary source
HGNC:HGNC:14628
See related
Ensembl:ENSG00000144354 MIM:609937; AllianceGenome:HGNC:14628
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ICF3; JPO1
Summary
This gene was identified as a c-Myc responsive gene, and behaves as a direct c-Myc target gene. Overexpression of this gene is found to enhance the transformation of lymphoblastoid cells, and it complements a transformation-defective Myc Box II mutant, suggesting its involvement in c-Myc-mediated cell transformation. Two alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 15.2), duodenum (RPKM 15.1) and 14 other tissues See more
Orthologs
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Genomic context

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Location:
2q31.1
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (173354872..173368997)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (173841091..173855221)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (174219600..174233725)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene MED14-independent group 3 enhancer GRCh37_chr2:174164665-174165864 Neighboring gene ribosomal protein S2 pseudogene 18 Neighboring gene cytochrome c oxidase subunit 7B pseudogene Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:174218644-174219599 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16767 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12115 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:174280529-174281037 Neighboring gene uncharacterized LOC105373744 Neighboring gene JPT1 pseudogene 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. CDCA7 promotes TGF-β-induced epithelial-mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC. Li H, et al. Cancer Sci, 2023 Jan. PMID 36056599, Free PMC Article
  2. High expression of CDCA7 predicts tumor progression and poor prognosis in human colorectal cancer. Li S, et al. Mol Med Rep, 2020 Jul. PMID 32319649, Free PMC Article
  3. CDCA7 promotes lung adenocarcinoma proliferation via regulating the cell cycle. Wang H, et al. Pathol Res Pract, 2019 Nov. PMID 31570276
  4. CDCA7 is a critical mediator of lymphomagenesis that selectively regulates anchorage-independent growth. Jiménez-P R, et al. Haematologica, 2018 Oct. PMID 29880607, Free PMC Article
  5. Downregulation of cell division cycle-associated protein 7 (CDCA7) suppresses cell proliferation, arrests cell cycle of ovarian cancer, and restrains angiogenesis by modulating enhancer of zeste homolog 2 (EZH2) expression. Cai C, et al. Bioengineered, 2021 Dec. PMID 34551671, Free PMC Article

See all (42) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. High Expression of CDCA7 in the Prognosis of Glioma and Its Relationship with Ferroptosis and Immunity.
    Title: High Expression of CDCA7 in the Prognosis of Glioma and Its Relationship with Ferroptosis and Immunity.
  2. CDCA7 promotes TGF-beta-induced epithelial-mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC.
    Title: CDCA7 promotes TGF-β-induced epithelial-mesenchymal transition via transcriptionally regulating Smad4/Smad7 in ESCC.
  3. CDCA7-regulated inflammatory mechanism through TLR4/NF-kappaB signaling pathway in stomach adenocarcinoma.
    Title: CDCA7-regulated inflammatory mechanism through TLR4/NF-κB signaling pathway in stomach adenocarcinoma.
  4. Downregulation of cell division cycle-associated protein 7 (CDCA7) suppresses cell proliferation, arrests cell cycle of ovarian cancer, and restrains angiogenesis by modulating enhancer of zeste homolog 2 (EZH2) expression.
    Title: Downregulation of cell division cycle-associated protein 7 (CDCA7) suppresses cell proliferation, arrests cell cycle of ovarian cancer, and restrains angiogenesis by modulating enhancer of zeste homolog 2 (EZH2) expression.
  5. CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats.
    Title: CDCA7 and HELLS suppress DNA:RNA hybrid-associated DNA damage at pericentromeric repeats.
  6. High expression of CDCA7 predicts tumor progression and poor prognosis in human colorectal cancer.
    Title: High expression of CDCA7 predicts tumor progression and poor prognosis in human colorectal cancer.
  7. ZBTB24 activates the expression of CDCA7 in T cells.
    Title: ZBTB24 regulates the apoptosis of human T cells via CDCA7/TRAIL-receptor axis.
  8. the CDCA7 gene may play a tumor-promoting role in lung adenocarcinoma
    Title: CDCA7 promotes lung adenocarcinoma proliferation via regulating the cell cycle.
  9. The inhibiting effects of FGD5-AS1 knockdown on colorectal cancer (CRC) cell proliferation, migration, and invasion, and the promoting effects on CRC cell apoptosis could be revived by miR-302e suppression or CDCA7 upregulation.
    Title: Long noncoding RNA FGD5-AS1 promotes colorectal cancer cell proliferation, migration, and invasion through upregulating CDCA7 via sponging miR-302e.
  10. the C-NHEJ defect alone did not cause CG hypomethylation, CDCA7 and HELLS are involved in maintaining CG methylation at centromeric and pericentromeric repeats. The defect in C-NHEJ may account for some common features of immunodeficiency, centromeric instability, and facial anomalies (ICF) syndrome cells, including centromeric instability, abnormal chromosome segregation, and apoptosis.
    Title: CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome.
Submit: New GeneRIF Correction See all GeneRIFs (21)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Immunodeficiency-centromeric instability-facial anomalies syndrome 3
MedGen: C4310799 OMIM: 616910 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2.
EBI GWAS Catalog
Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.
EBI GWAS Catalog
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.
EBI GWAS Catalog
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ14722, FLJ14736, MGC34109

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cell division cycle-associated protein 7
Names
c-Myc target JPO1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047202.1 RefSeqGene

    Range
    5856..19981
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_031942.5 → NP_114148.3  cell division cycle-associated protein 7 isoform 1

    See identical proteins and their annotated locations for NP_114148.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AC092573, AY029179, BC015124, DA531905
    Consensus CDS
    CCDS2252.1
    UniProtKB/TrEMBL
    A0A8Q3WKV4
    Related
    ENSP00000306968.3, ENST00000306721.8
    Conserved Domains (1) summary
    pfam10497
    Location:341 → 439
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

  2. NM_145810.3 → NP_665809.1  cell division cycle-associated protein 7 isoform 2

    See identical proteins and their annotated locations for NP_665809.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame coding segment compared to variant 1. The resulting isoform (2) lacks an internal region, as compared to isoform 1.
    Source sequence(s)
    AC092573, AY029179, BC015124
    Consensus CDS
    CCDS2253.1
    UniProtKB/Swiss-Prot
    B4DLP8, B4DV66, Q53EW5, Q580W9, Q658K4, Q658N4, Q8NBY9, Q96BV8, Q96SP5, Q9BWT1
    UniProtKB/TrEMBL
    A0A8Q3SIB2
    Related
    ENSP00000272789.4, ENST00000347703.7
    Conserved Domains (1) summary
    pfam10497
    Location:266 → 360
    zf-4CXXC_R1; Zinc-finger domain of monoamine-oxidase A repressor R1

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    173354872..173368997
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047445957.1 → XP_047301913.1  cell division cycle-associated protein 7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    173841091..173855221
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054344112.1 → XP_054200087.1  cell division cycle-associated protein 7 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BWT1.1 GenPept UniProtKB/Swiss-Prot:Q9BWT1

Gene LinkOut

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