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GPR61 G protein-coupled receptor 61 [ Homo sapiens (human) ]

Gene ID: 83873, updated on 11-Apr-2024

Summary

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Official Symbol
GPR61provided by HGNC
Official Full Name
G protein-coupled receptor 61provided by HGNC
Primary source
HGNC:HGNC:13300
See related
Ensembl:ENSG00000156097 MIM:606916; AllianceGenome:HGNC:13300
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BALGR; GPCR3
Summary
This gene belongs to the G-protein coupled receptor 1 family. G protein-coupled receptors contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins. The protein encoded by this gene is most closely related to biogenic amine receptors. [provided by RefSeq, Jul 2008]
Expression
Biased expression in brain (RPKM 1.2), thyroid (RPKM 0.5) and 3 other tissues See more
Orthologs
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Genomic context

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Location:
1p13.3
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (109539872..109547260)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (109572595..109579983)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (110082494..110089882)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1153 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1154 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1155 Neighboring gene uncharacterized LOC105378893 Neighboring gene adhesion molecule with Ig like domain 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1442 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1443 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110073289-110073457 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110082007-110082508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110082509-110083008 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:110086313-110086851 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:110089013-110089249 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1444 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1445 Neighboring gene G protein subunit alpha i3 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:110106789-110107398 Neighboring gene RNA, U6 small nuclear variant sequence with SNRPE pseudogene sequence Neighboring gene microRNA 197

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity. Toyooka M, et al. J Neurosci Res, 2009 May 1. PMID 19025769
  2. A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors. Conner AC, et al. Mol Pharmacol, 2005 Jan. PMID 15615699
  3. Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain. Cikos S, et al. Biochim Biophys Acta, 2001 Oct 31. PMID 11690637
  4. Identification of four novel human G protein-coupled receptors expressed in the brain. Lee DK, et al. Brain Res Mol Brain Res, 2001 Jan 31. PMID 11165367
  5. Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions. Oishi A, et al. Sci Rep, 2017 Aug 21. PMID 28827538, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Collectively, these data show that GPR61, GPR62 and GPR135 are unable to bind melatonin, but show a reciprocal regulatory interaction with MT2 receptors.
    Title: Orphan GPR61, GPR62 and GPR135 receptors and the melatonin MT(2) receptor reciprocally modulate their signaling functions.
  2. Observational study of gene-disease association. (HuGE Navigator)
    Title: Sequential use of transcriptional profiling, expression quantitative trait mapping, and gene association implicates MMP20 in human kidney aging.
  3. We conclude that the N-terminal domain of GPR61 is required for maintaining its constitutive activity and functions as a tethered intramolecular ligand.
    Title: The N-terminal domain of GPR61, an orphan G-protein-coupled receptor, is essential for its constitutive activity.
  4. maps to chromosome 1, is widely expressed, with expression highest in the brain areas associated with cognition, learning, and memory.
    Title: Cloning of a novel biogenic amine receptor-like G protein-coupled receptor expressed in human brain.
  5. Modeling rationalizes the effects of transmembrane proline mutants previously reported for another family of GPCR.
    Title: A key role for transmembrane prolines in calcitonin receptor-like receptor agonist binding and signalling: implications for family B G-protein-coupled receptors.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables arrestin family protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ligand-independent adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of receptor complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
G-protein coupled receptor 61
Names
biogenic amine receptor-like G-protein coupled receptor
biogenic amine receptor-like GPCR
probable G-protein coupled receptor 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032758.2 RefSeqGene

    Range
    5001..12389
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001393907.1 → NP_001380836.1  G-protein coupled receptor 61

    Status: REVIEWED

    Source sequence(s)
    AL355145, AL355310
    Consensus CDS
    CCDS801.1
    UniProtKB/Swiss-Prot
    A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
    UniProtKB/TrEMBL
    G4XH66
    Related
    ENSP00000432456.1, ENST00000527748.5
    Conserved Domains (1) summary
    cd15220
    Location:44 → 352
    7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors

  2. NM_031936.6 → NP_114142.3  G-protein coupled receptor 61

    See identical proteins and their annotated locations for NP_114142.3

    Status: REVIEWED

    Source sequence(s)
    AF258342, AL355310, DA176879
    Consensus CDS
    CCDS801.1
    UniProtKB/Swiss-Prot
    A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
    UniProtKB/TrEMBL
    G4XH66
    Related
    ENSP00000385422.2, ENST00000404129.6
    Conserved Domains (1) summary
    cd15220
    Location:44 → 352
    7tmA_GPR61_GPR62-like; G protein-coupled receptors 61 and 62, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    109539872..109547260
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431615.1 → XP_047287571.1  G-protein coupled receptor 61 isoform X1

    UniProtKB/Swiss-Prot
    A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
    UniProtKB/TrEMBL
    G4XH66

  2. XM_047431617.1 → XP_047287573.1  G-protein coupled receptor 61 isoform X1

    UniProtKB/Swiss-Prot
    A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
    UniProtKB/TrEMBL
    G4XH66
    Related
    ENSP00000433661.1, ENST00000469383.2

  3. XM_047431614.1 → XP_047287570.1  G-protein coupled receptor 61 isoform X1

    UniProtKB/Swiss-Prot
    A8K1W2, Q6NWS0, Q8TDV4, Q96PR4, Q9BZJ8
    UniProtKB/TrEMBL
    G4XH66

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    109572595..109579983
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_008486172.1 RNA Sequence

  2. XR_008486171.1 RNA Sequence

  3. XR_008486173.1 RNA Sequence

  4. XR_008486174.1 RNA Sequence

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BZJ8.2 GenPept UniProtKB/Swiss-Prot:Q9BZJ8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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