Dpp7 dipeptidylpeptidase 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dpp7provided by MGI
Official Full Name: dipeptidylpeptidase 7provided by MGI
Primary source: MGI:MGI:1933213
See related: Ensembl:ENSMUSG00000026958 AllianceGenome:MGI:1933213
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: QPP; Dpp2; DPPII
Summary: Enables dipeptidyl-peptidase activity. Acts upstream of or within lysosomal protein catabolic process. Located in lysosome. Is expressed in 1st branchial arch and embryo. Orthologous to human DPP7 (dipeptidyl peptidase 7). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in kidney adult (RPKM 42.2), placenta adult (RPKM 32.5) and 26 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 17.19 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (25242302..25246365, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (25352290..25356389, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

gene deficiency results in Th17 differentiation and peripheral T cells hyperactivation upon TCR stimulation
Title: Th17 differentiation is the default program for DPP2-deficient T-cell differentiation.
Data show that an increase in food intake in DPP2 kd mice, which was associated with a significant increase in adipose tissue mass and enhanced liver steatosis but no difference in body weight.
Title: Neurogenin 3-specific dipeptidyl peptidase-2 deficiency causes impaired glucose tolerance, insulin resistance, and visceral obesity.
KLF2 and TOB1 activate the mouse Dpp2 promoter.
Title: Lymphocyte quiescence factor Dpp2 is transcriptionally activated by KLF2 and TOB1.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables aminopeptidase activity	IEA Inferred from Electronic Annotation more info
enables dipeptidyl-peptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables dipeptidyl-peptidase activity	IDA Inferred from Direct Assay more info	PubMed
enables dipeptidyl-peptidase activity	ISO Inferred from Sequence Orthology more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables peptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type exopeptidase activity	IEA Inferred from Electronic Annotation more info
enables serine-type peptidase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within lysosomal protein catabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within proteolysis	IEA Inferred from Electronic Annotation more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in cytoplasmic vesicle	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in lysosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in vesicle	IBA Inferred from Biological aspect of Ancestor more info
located_in vesicle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: dipeptidyl peptidase 2

Names: DPP II; dipeptidyl aminopeptidase II; dipeptidyl peptidase II; quiescent cell proline dipeptidase

NP_001405805.1

EC 3.4.14.2

NP_114031.2

EC 3.4.14.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001418876.1 → NP_001405805.1 dipeptidyl peptidase 2 isoform 2 precursor

Status: VALIDATED

Source sequence(s)

AL732557
NM_031843.3 → NP_114031.2 dipeptidyl peptidase 2 isoform 1 precursor

See identical proteins and their annotated locations for NP_114031.2

Status: VALIDATED

Source sequence(s)

AL732557

Consensus CDS

CCDS15766.1

UniProtKB/Swiss-Prot

Q8R082, Q9ET22

Related

ENSMUSP00000028332.8, ENSMUST00000028332.8

Conserved Domains (1) summary

cl21494
Location:48 → 475

Abhydrolase; alpha/beta hydrolases