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Slc12a9 solute carrier family 12 (potassium/chloride transporters), member 9 [ Mus musculus (house mouse) ]

Gene ID: 83704, updated on 21-Apr-2024

Summary

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Official Symbol
Slc12a9provided by MGI
Official Full Name
solute carrier family 12 (potassium/chloride transporters), member 9provided by MGI
Primary source
MGI:MGI:1933532
See related
Ensembl:ENSMUSG00000037344 AllianceGenome:MGI:1933532
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CIP1
Summary
Predicted to enable potassium:chloride symporter activity. Predicted to be involved in cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Predicted to be integral component of membrane. Is expressed in genitourinary system; integumental system; nervous system; sensory organ; and skeleton. Orthologous to human SLC12A9 (solute carrier family 12 member 9). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 11.1), adrenal adult (RPKM 11.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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Location:
5 G2; 5 76.35 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (137312820..137338331, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (137314558..137340070, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 43013 Neighboring gene thyroid hormone receptor interactor 6 Neighboring gene STARR-positive B cell enhancer ABC_E9655 Neighboring gene STARR-seq mESC enhancer starr_14641 Neighboring gene predicted gene, 52791 Neighboring gene Eph receptor B4 Neighboring gene STARR-seq mESC enhancer starr_14643

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CIP1 is an activator of the K+-Cl- cotransporter KCC2. Wenz M, et al. Biochem Biophys Res Commun, 2009 Apr 10. PMID 19232517
  2. Cation-chloride cotransporters and neuronal function. Blaesse P, et al. Neuron, 2009 Mar 26. PMID 19323993
  3. Comparative analysis of the gene-dense ACHE/TFR2 region on human chromosome 7q22 with the orthologous region on mouse chromosome 5. Wilson MD, et al. Nucleic Acids Res, 2001 Mar 15. PMID 11239002, Free PMC Article
  4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
  5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (2) 
  • Endonuclease-mediated (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chloride:monoatomic cation symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane ISO
Inferred from Sequence Orthology
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
solute carrier family 12 member 9
Names
cation-chloride cotransporter-interacting protein 1
potassium-chloride transporter 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001359611.1 → NP_001346540.1  solute carrier family 12 member 9

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC150682
    Consensus CDS
    CCDS19766.1
    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

  2. NM_031406.3 → NP_113583.2  solute carrier family 12 member 9

    See identical proteins and their annotated locations for NP_113583.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AC150682
    Consensus CDS
    CCDS19766.1
    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Related
    ENSMUSP00000038106.8, ENSMUST00000039991.14
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    137312820..137338331 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254934.2 → XP_030110794.1  solute carrier family 12 member 9 isoform X1

    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

  2. XM_030254938.2 → XP_030110798.1  solute carrier family 12 member 9 isoform X1

    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

  3. XM_030254937.2 → XP_030110797.1  solute carrier family 12 member 9 isoform X1

    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

  4. XM_030254933.2 → XP_030110793.1  solute carrier family 12 member 9 isoform X1

    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

  5. XM_036165634.1 → XP_036021527.1  solute carrier family 12 member 9 isoform X1

    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

  6. XM_030254931.2 → XP_030110791.1  solute carrier family 12 member 9 isoform X1

    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

  7. XM_030254935.2 → XP_030110795.1  solute carrier family 12 member 9 isoform X1

    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

  8. XM_030254932.2 → XP_030110792.1  solute carrier family 12 member 9 isoform X1

    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

  9. XM_030254936.1 → XP_030110796.1  solute carrier family 12 member 9 isoform X1

    UniProtKB/Swiss-Prot
    E9QNN4, Q99MR3
    Conserved Domains (1) summary
    TIGR00930
    Location:36 → 905
    2a30; K-Cl cotransporter

RNA

  1. XR_001784760.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MR3.2 GenPept UniProtKB/Swiss-Prot:Q99MR3

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