Cnnm1 cyclin M1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cnnm1provided by MGI
Official Full Name: cyclin M1provided by MGI
Primary source: MGI:MGI:1891366
See related: Ensembl:ENSMUSG00000025189 AllianceGenome:MGI:1891366
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Acdp1; CLP-1
Summary: Predicted to enable transmembrane transporter activity. Predicted to act upstream of or within ion transport. Located in dendrite; neuronal cell body; and plasma membrane. Orthologous to human CNNM1 (cyclin and CBS domain divalent metal cation transport mediator 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in cerebellum adult (RPKM 15.2), cortex adult (RPKM 9.8) and 7 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C3; 19 36.67 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (43427508..43485649)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (43439069..43497210)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CNNM1 expression was restricted to c-KIT- and OCT3/4-positive cells in the testis, indicating that they are early spermatogonial cells. Spermatogonial stem cells in primary culture expressed Cnnm1, and their differentiation into embryoid body-like clusters in vitro resulted in the loss of Cnnm1 expression. Silencing of Cnnm1 in GC1-spg cells reduced number of cells in G1 phase with increased cells in S and G2/M phases.
Title: Expression of Cnnm1 and Its Association with Stemness, Cell Cycle, and Differentiation in Spermatogenic Cells in Mouse Testis.
We determined that ACDP-1 is a high affinity copper binding protein able to bind copper at nanomolar concentrations. In addition the promoter of ACDP-1 contains metal response elements and cellular expression of ACDP-1 alters cellular retention of copper.
Title: Ancient conserved domain protein-1 binds copper and modifies its retention in cells.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in magnesium ion homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within monoatomic ion transport	IEA Inferred from Electronic Annotation more info
involved_in transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metal transporter CNNM1

Names: ancient conserved domain protein 1; ancient conserved domain-containing protein 1; cyclin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001373992.1 → NP_001360921.1 metal transporter CNNM1 isoform 1

Status: VALIDATED

Source sequence(s)

AC140375

Consensus CDS

CCDS89394.1

UniProtKB/TrEMBL

A0A286YDL2

Related

ENSMUSP00000153472.2, ENSMUST00000223787.2

Conserved Domains (1) summary

COG1253
Location:251 → 553

TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
NM_001424972.1 → NP_001411901.1 metal transporter CNNM1 isoform 3

Status: VALIDATED

Source sequence(s)

AC140375
NM_031396.3 → NP_113573.2 metal transporter CNNM1 isoform 2

See identical proteins and their annotated locations for NP_113573.2

Status: VALIDATED

Source sequence(s)

AC140375, AF202994, EF041508

Consensus CDS

CCDS50442.1

UniProtKB/Swiss-Prot

Q0GA42, Q9JIQ6

Related

ENSMUSP00000131830.2, ENSMUST00000165311.3

Conserved Domains (1) summary

COG1253
Location:251 → 553

TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

43427508..43485649

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006527480.5 → XP_006527543.1 metal transporter CNNM1 isoform X1

Conserved Domains (1) summary

COG1253
Location:251 → 553

TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
XM_006527482.5 → XP_006527545.1 metal transporter CNNM1 isoform X2

Conserved Domains (1) summary

COG1253
Location:251 → 553

TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]
XM_036161732.1 → XP_036017625.1 metal transporter CNNM1 isoform X3

Conserved Domains (1) summary

COG1253
Location:251 → 553

TlyC; Hemolysin or related protein, contains CBS domains [General function prediction only]