Dedd death effector domain-containing [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Deddprovided by RGD
Official Full Name: death effector domain-containingprovided by RGD
Primary source: RGD:620050
See related: Ensembl:ENSRNOG00000003779 AllianceGenome:RGD:620050
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Deft
Summary: Predicted to enable DNA binding activity. Involved in spermatogenesis. Predicted to be located in cytoplasm. Predicted to be active in nucleolus. Orthologous to human DEDD (death effector domain containing). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Kidney (RPKM 123.9), Muscle (RPKM 106.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 13q24

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	13	NC_086031.1 (86286341..86301789)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	13	NC_051348.1 (83755874..83769982)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	13	NC_005112.4 (89706932..89721825)

Chromosome 13 - NC_086031.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within decidualization	ISO Inferred from Sequence Orthology more info
involved_in extrinsic apoptotic signaling pathway via death domain receptors	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within extrinsic apoptotic signaling pathway via death domain receptors	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within negative regulation of transcription of nucleolar large rRNA by RNA polymerase I	ISO Inferred from Sequence Orthology more info
involved_in regulation of apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEP Inferred from Expression Pattern more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in nucleolus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: death effector domain-containing protein

Names: death effector domain-containing testicular molecule

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031800.1 → NP_113988.1 death effector domain-containing protein

See identical proteins and their annotated locations for NP_113988.1

Status: PROVISIONAL

Source sequence(s)

AF053362

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6

Conserved Domains (1) summary

cd08790
Location:22 → 118

DED_DEDD; Death Effector Domain of DEDD

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086031.1 Reference GRCr8

Range

86286341..86301789

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017598942.3 → XP_017454431.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6

Conserved Domains (1) summary

cd08790
Location:22 → 118

DED_DEDD; Death Effector Domain of DEDD
XM_017598945.3 → XP_017454434.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6

Conserved Domains (1) summary

cd08790
Location:22 → 118

DED_DEDD; Death Effector Domain of DEDD
XM_017598943.3 → XP_017454432.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6

Conserved Domains (1) summary

cd08790
Location:22 → 118

DED_DEDD; Death Effector Domain of DEDD
XM_006250269.5 → XP_006250331.1 death effector domain-containing protein isoform X1

See identical proteins and their annotated locations for XP_006250331.1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6

Conserved Domains (1) summary

cd08790
Location:22 → 118

DED_DEDD; Death Effector Domain of DEDD
XM_063272644.1 → XP_063128714.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6
XM_063272646.1 → XP_063128716.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6
XM_006250274.5 → XP_006250336.1 death effector domain-containing protein isoform X1

See identical proteins and their annotated locations for XP_006250336.1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6

Conserved Domains (1) summary

cd08790
Location:22 → 118

DED_DEDD; Death Effector Domain of DEDD
XM_039091125.2 → XP_038947053.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6

Related

ENSRNOP00000005147.1

Conserved Domains (1) summary

cd08790
Location:22 → 118

DED_DEDD; Death Effector Domain of DEDD
XM_006250272.5 → XP_006250334.1 death effector domain-containing protein isoform X1

See identical proteins and their annotated locations for XP_006250334.1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6

Conserved Domains (1) summary

cd08790
Location:22 → 118

DED_DEDD; Death Effector Domain of DEDD
XM_017598946.3 → XP_017454435.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6

Conserved Domains (1) summary

cd08790
Location:22 → 118

DED_DEDD; Death Effector Domain of DEDD
XM_017598944.3 → XP_017454433.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6

Conserved Domains (1) summary

cd08790
Location:22 → 118

DED_DEDD; Death Effector Domain of DEDD
XM_063272648.1 → XP_063128718.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6
XM_063272647.1 → XP_063128717.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6
XM_063272650.1 → XP_063128720.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6
XM_063272649.1 → XP_063128719.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6
XM_063272645.1 → XP_063128715.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6
XM_063272643.1 → XP_063128713.1 death effector domain-containing protein isoform X1

UniProtKB/Swiss-Prot

Q9Z2K0

UniProtKB/TrEMBL

A6JFX6