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Nlrp4c NLR family, pyrin domain containing 4C [ Mus musculus (house mouse) ]

Gene ID: 83564, updated on 8-Feb-2024

Summary

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Official Symbol
Nlrp4cprovided by MGI
Official Full Name
NLR family, pyrin domain containing 4Cprovided by MGI
Primary source
MGI:MGI:1890518
See related
Ensembl:ENSMUSG00000034690 AllianceGenome:MGI:1890518
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Rnh2; Nalp4c; Nalp-alpha
Summary
Predicted to enable ATP binding activity. Predicted to act upstream of or within inflammatory response. Is expressed in nervous system. Orthologous to human NLRP4 (NLR family pyrin domain containing 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
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Genomic context

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Location:
7 A1; 7 3.5 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (6048160..6108148)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (6045161..6105149)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene protein tyrosine phosphatase 4a1 pseudogene Neighboring gene RIKEN cDNA 4933402C05 gene Neighboring gene crumbs homolog 1 pseudogene Neighboring gene predicted gene, 18758 Neighboring gene zinc finger protein 787 Neighboring gene STARR-positive B cell enhancer ABC_E9284 Neighboring gene predicted gene, 36371

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The mouse germ-cell-specific leucine-rich repeat protein NALP14: a member of the NACHT nucleoside triphosphatase family. Horikawa M, et al. Biol Reprod, 2005 Apr. PMID 15590904
  2. Differences in gene expression between mouse and human for dynamically regulated genes in early embryo. Madissoon E, et al. PLoS One, 2014. PMID 25089626, Free PMC Article
  3. Hormad1 mutation disrupts synaptonemal complex formation, recombination, and chromosome segregation in mammalian meiosis. Shin YH, et al. PLoS Genet, 2010 Nov 4. PMID 21079677, Free PMC Article
  4. An abundance of X-linked genes expressed in spermatogonia. Wang PJ, et al. Nat Genet, 2001 Apr. PMID 11279525
  5. Age-associated alteration of gene expression patterns in mouse oocytes. Hamatani T, et al. Hum Mol Genet, 2004 Oct 1. PMID 15317747

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3) 

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISO
Inferred from Sequence Orthology
more info
  
enables molecular_function ND
No biological Data available
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
  
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of innate immune response ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
NACHT, LRR and PYD domains-containing protein 4C
Names
NACHT, leucine rich repeat and PYD containing 4C
VNACHT, leucine rich repeat and PYD containing 4C
ribonuclease/angiogenin inhibitor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031389.2 → NP_113566.2  NACHT, LRR and PYD domains-containing protein 4C

    See identical proteins and their annotated locations for NP_113566.2

    Status: VALIDATED

    Source sequence(s)
    AK166817, AY596194
    Consensus CDS
    CCDS51988.1
    UniProtKB/Swiss-Prot
    Q3TKR3, Q66X27
    Related
    ENSMUSP00000046503.6, ENSMUST00000037728.13
    Conserved Domains (5) summary
    COG4886
    Location:742 → 960
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    cd00116
    Location:689 → 953
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    cd08320
    Location:10 → 92
    Pyrin_NALPs; Pyrin death domain found in NALP proteins
    sd00033
    Location:749 → 776
    LRR_RI; leucine-rich repeat [structural motif]
    pfam05729
    Location:148 → 317
    NACHT; NACHT domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    6048160..6108148
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TKR3.1 GenPept UniProtKB/Swiss-Prot:Q3TKR3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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