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Usp26 ubiquitin specific peptidase 26 [ Mus musculus (house mouse) ]

Gene ID: 83563, updated on 21-Apr-2024

Summary

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Official Symbol
Usp26provided by MGI
Official Full Name
ubiquitin specific peptidase 26provided by MGI
Primary source
MGI:MGI:1933247
See related
Ensembl:ENSMUSG00000055780 AllianceGenome:MGI:1933247
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Predicted to be involved in G1/S transition of mitotic cell cycle and protein deubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. Orthologous to human USP26 (ubiquitin specific peptidase 26). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
human all
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Genomic context

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Location:
X A5; X 28.31 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (50841544..50890110, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (51752667..51801233, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 57669 Neighboring gene STARR-seq mESC enhancer starr_47162 Neighboring gene heparan sulfate 6-O-sulfotransferase 2 Neighboring gene STARR-seq mESC enhancer starr_47163 Neighboring gene STARR-seq mESC enhancer starr_47164 Neighboring gene predicted gene, 35727 Neighboring gene STARR-seq mESC enhancer starr_47165 Neighboring gene predicted gene, 22539 Neighboring gene STARR-seq mESC enhancer starr_47166 Neighboring gene MAGE family member A14 Neighboring gene predicted gene, 35790

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. The osteoprotective role of USP26 in coordinating bone formation and resorption. Li C, et al. Cell Death Differ, 2022 Jun. PMID 35091692, Free PMC Article
  2. Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background. Sakai K, et al. Sci Rep, 2019 Sep 24. PMID 31551464, Free PMC Article
  3. Disruption of ubiquitin specific protease 26 gene causes male subfertility associated with spermatogenesis defects in mice†. Tian H, et al. Biol Reprod, 2019 Apr 1. PMID 30561524, Free PMC Article
  4. Localization of ubiquitin specific protease 26 at blood-testis barrier and near Sertoli cell-germ cell interface in mouse testes. Lin YW, et al. Int J Androl, 2011 Oct. PMID 21449984
  5. USP26 deubiquitinates androgen receptor (AR) in the maintenance of sperm maturation and spermatogenesis through the androgen receptor signaling pathway. Wang J, et al. Adv Clin Exp Med, 2020 Oct. PMID 33064378

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations.
    Title: An RNF12-USP26 amplification loop drives germ cell specification and is disrupted by disease-associated mutations.
  2. The osteoprotective role of USP26 in coordinating bone formation and resorption.
    Title: The osteoprotective role of USP26 in coordinating bone formation and resorption.
  3. Ubiquitin-Specific Protease 29 Exacerbates Cerebral Ischemia-Reperfusion Injury in Mice.
    Title: Ubiquitin-Specific Protease 29 Exacerbates Cerebral Ischemia-Reperfusion Injury in Mice.
  4. Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.
    Title: Paternal USP26 mutations raise Klinefelter syndrome risk in the offspring of mice and humans.
  5. Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background.
    Title: Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background.
  6. Germ-cell-specific sex-linked genes, like Usp26, are subject to meiotic sex-chromosome inactivation (MSCI) during spermatogenesis.
    Title: Differential expression of sex-linked and autosomal germ-cell-specific genes during spermatogenesis in the mouse.
  7. Usp26 is a testis-specific gene identified in a genome-wide cDNA subtraction screen.
    Title: An abundance of X-linked genes expressed in spermatogonia.
  8. The loss of Usp26 affects spermatogenesis and hormone secretion and causes male subfertility. This study also provides the evidence on the interactions between USP26 and androgen receptor in mouse testis, whereby pointing to a potential mechanism.
    Title: Disruption of ubiquitin specific protease 26 gene causes male subfertility associated with spermatogenesis defects in mice†.
  9. RT-PCR assays detected the expression of Usp26 in germ cells, but not in primary Sertoli cell lines
    Title: Localization of ubiquitin specific protease 26 at blood-testis barrier and near Sertoli cell-germ cell interface in mouse testes.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • MGC159157

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables K48-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in protein deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of androgen receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in spermatogenesis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in sperm flagellum ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 26
Names
deubiquitinating enzyme 26
ubiquitin specific protease 26
ubiquitin thioesterase 26
ubiquitin thiolesterase 26
ubiquitin-specific-processing protease 26
NP_113565.2
XP_017174134.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031388.2 → NP_113565.2  ubiquitin carboxyl-terminal hydrolase 26

    See identical proteins and their annotated locations for NP_113565.2

    Status: VALIDATED

    Source sequence(s)
    AK133417, AL662931
    Consensus CDS
    CCDS30122.1
    UniProtKB/Swiss-Prot
    Q05A11, Q99MX1
    Related
    ENSMUSP00000110519.2, ENSMUST00000114869.8
    Conserved Domains (3) summary
    cd02257
    Location:747 → 814
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:287 → 553
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    50841544..50890110 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017318645.1 → XP_017174134.1  ubiquitin carboxyl-terminal hydrolase 26 isoform X1

    UniProtKB/Swiss-Prot
    Q05A11, Q99MX1
    Related
    ENSMUSP00000069140.4, ENSMUST00000069509.4
    Conserved Domains (3) summary
    cd02257
    Location:747 → 814
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:287 → 553
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam16674
    Location:3 → 104
    UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99MX1.2 GenPept UniProtKB/Swiss-Prot:Q99MX1

Gene LinkOut

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