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Chrdl1 chordin-like 1 [ Mus musculus (house mouse) ]

Gene ID: 83453, updated on 11-Apr-2024

Summary

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Official Symbol
Chrdl1provided by MGI
Official Full Name
chordin-like 1provided by MGI
Primary source
MGI:MGI:1933172
See related
Ensembl:ENSMUSG00000031283 AllianceGenome:MGI:1933172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CHL; CHL1; VOPT; Nrln1
Summary
Acts upstream of or within negative regulation of BMP signaling pathway. Predicted to be located in extracellular region. Is expressed in several structures, including alimentary system; embryo mesenchyme; genitourinary system; neural ectoderm; and skeletal system. Human ortholog(s) of this gene implicated in megalocornea. Orthologous to human CHRDL1 (chordin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in genital fat pad adult (RPKM 5.5), bladder adult (RPKM 4.9) and 18 other tissues See more
Orthologs
human all
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Genomic context

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Location:
X F2; X 64.24 cM
Exon count:
12
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (142068670..142177282, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (143285674..143394263, complement)

Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene retrotransposon Gag like 9 Neighboring gene STARR-seq mESC enhancer starr_48027 Neighboring gene STARR-seq mESC enhancer starr_48028 Neighboring gene STARR-seq mESC enhancer starr_48029 Neighboring gene actin, beta pseudogene Neighboring gene STARR-seq mESC enhancer starr_48030 Neighboring gene predicted gene, 23325 Neighboring gene STARR-seq mESC enhancer starr_48031 Neighboring gene p21 (RAC1) activated kinase 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Chordin-like 1, a Novel Adipokine, Markedly Promotes Adipogenesis and Lipid Accumulation. Ahn J, et al. Cells, 2023 Feb 15. PMID 36831292, Free PMC Article
  2. Astrocyte-secreted chordin-like 1 regulates spine density after ischemic injury. Blanco-Suarez E, et al. Sci Rep, 2022 Mar 9. PMID 35264691, Free PMC Article
  3. Ocular Manifestations of Chordin-like 1 Knockout Mice. Chen D, et al. Cornea, 2020 Sep. PMID 32452990, Free PMC Article
  4. Neurogenesin-1 differentially inhibits the osteoblastic differentiation by bone morphogenetic proteins in C2C12 cells. Chandra A, et al. Biochem Biophys Res Commun, 2006 Jun 9. PMID 16630536
  5. Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation Through Stabilizing Insulin-Like Growth Factor Binding Protein 3. Sun H, et al. Stem Cells, 2023 Apr 25. PMID 36682027

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation Through Stabilizing Insulin-Like Growth Factor Binding Protein 3.
    Title: Chordin Like-1 Regulates Osteoblast and Adipocyte Differentiation Through Stabilizing Insulin-Like Growth Factor Binding Protein 3.
  2. Chordin-like 1, a Novel Adipokine, Markedly Promotes Adipogenesis and Lipid Accumulation.
    Title: Chordin-like 1, a Novel Adipokine, Markedly Promotes Adipogenesis and Lipid Accumulation.
  3. Astrocyte-secreted chordin-like 1 regulates spine density after ischemic injury.
    Title: Astrocyte-secreted chordin-like 1 regulates spine density after ischemic injury.
  4. Ocular Manifestations of Chordin-like 1 Knockout Mice.
    Title: Ocular Manifestations of Chordin-like 1 Knockout Mice.
  5. study identified that astrocyte-secreted chordin-like 1 (Chrdl1) is necessary and sufficient to induce mature GluA2-containing synapses to form.
    Title: Astrocyte-Secreted Chordin-like 1 Drives Synapse Maturation and Limits Plasticity by Increasing Synaptic GluA2 AMPA Receptors.
  6. CHRDL-1 is a new regulatory target of miR-134 during cortical neuronal differentiation; this is a novel role for miR-134 in the modulation of cortical development.
    Title: Stage-specific modulation of cortical neuronal development by Mmu-miR-134.
  7. Reperfusion injury of proximal kidney tubules causes a reduction of Chrdl1 expression.
    Title: Chordin-like 1 and twisted gastrulation 1 regulate BMP signaling following kidney injury.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables BMP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables BMP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables transforming growth factor beta binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in AMPA glutamate receptor clustering IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell fate determination ISO
Inferred from Sequence Orthology
more info
  
involved_in embryonic axis specification IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in excitatory chemical synaptic transmission IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in eye development ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of BMP signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron differentiation ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of synaptic plasticity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in extracellular region IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
chordin-like protein 1
Names
neuralin-1
neurogenesin-1
ventroptin-alpha
ventroptin-beta

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001114385.1 → NP_001107857.1  chordin-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001107857.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the shorter transcript and encodes the longer isoform (1).
    Source sequence(s)
    AF321853, AL713920, BX119959
    Consensus CDS
    CCDS53208.1
    UniProtKB/Swiss-Prot
    Q920C1, Q924K0, Q9EPZ9
    Related
    ENSMUSP00000108499.3, ENSMUST00000112878.9
    Conserved Domains (1) summary
    cl17735
    Location:110 → 173
    VWC; von Willebrand factor type C domain

  2. NM_001358592.1 → NP_001345521.1  chordin-like protein 1 isoform 3 precursor

    Status: VALIDATED

    Source sequence(s)
    AL713920, BX119959
    Conserved Domains (1) summary
    cl17735
    Location:111 → 174
    VWC; von Willebrand factor type C domain

  3. NM_031258.3 → NP_112548.2  chordin-like protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_112548.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 3' UTR and lacks a portion of the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AF296451, AL713920, BX119959
    Consensus CDS
    CCDS30453.1
    UniProtKB/TrEMBL
    Q3TP73, Q6NXY0
    Related
    ENSMUSP00000074230.6, ENSMUST00000074660.12
    Conserved Domains (1) summary
    cl17735
    Location:110 → 173
    VWC; von Willebrand factor type C domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000086.8 Reference GRCm39 C57BL/6J

    Range
    142068670..142177282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006529001.5 → XP_006529064.1  chordin-like protein 1 isoform X1

    Conserved Domains (1) summary
    cl17735
    Location:111 → 174
    VWC; von Willebrand factor type C domain

  2. XM_006529002.5 → XP_006529065.1  chordin-like protein 1 isoform X2

    Conserved Domains (1) summary
    cl17735
    Location:110 → 173
    VWC; von Willebrand factor type C domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q920C1.1 GenPept UniProtKB/Swiss-Prot:Q920C1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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