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ADPGK ADP dependent glucokinase [ Homo sapiens (human) ]

Gene ID: 83440, updated on 3-Apr-2024

Summary

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Official Symbol
ADPGKprovided by HGNC
Official Full Name
ADP dependent glucokinaseprovided by HGNC
Primary source
HGNC:HGNC:25250
See related
Ensembl:ENSG00000159322 MIM:611861; AllianceGenome:HGNC:25250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ADP-GK; 2610017G09Rik
Summary
ADPGK (EC 2.7.1.147) catalyzes the ADP-dependent phosphorylation of glucose to glucose-6-phosphate and may play a role in glycolysis, possibly during ischemic conditions (Ronimus and Morgan, 2004 [PubMed 14975750]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 23.6), appendix (RPKM 19.7) and 25 other tissues See more
Orthologs
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Genomic context

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See ADPGK in Genome Data Viewer
Location:
15q24.1
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (72751294..72783758, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (70568596..70601068, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (73043635..73076099, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene HIG1 hypoxia inducible domain family member 2B Neighboring gene MPRA-validated peak2381 silencer Neighboring gene Bardet-Biedl syndrome 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9728 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6626 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9729 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9730 Neighboring gene ADPGK antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:73099527-73100423 Neighboring gene NANOG hESC enhancer GRCh37_chr15:73113063-73113588 Neighboring gene uncharacterized LOC107984801 Neighboring gene NANOG hESC enhancer GRCh37_chr15:73127371-73127872 Neighboring gene nucleophosmin 1 pseudogene 42

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Kinetic characterization and phylogenetic analysis of human ADP-dependent glucokinase reveal new insights into its regulatory properties. Herrera-Morandé A, et al. Arch Biochem Biophys, 2023 Jun. PMID 37084804
  2. ADP-dependent glucokinase as a novel onco-target for haematological malignancies. Tandon A, et al. Sci Rep, 2020 Aug 12. PMID 32788680, Free PMC Article
  3. Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism. Richter S, et al. PLoS One, 2013. PMID 23799003, Free PMC Article
  4. Expression and role in glycolysis of human ADP-dependent glucokinase. Richter S, et al. Mol Cell Biochem, 2012 May. PMID 22219026
  5. Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY). Cuesta-Muñoz AL, et al. Diabetes Care, 2010 Feb. PMID 19903754, Free PMC Article

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Kinetic characterization and phylogenetic analysis of human ADP-dependent glucokinase reveal new insights into its regulatory properties.
    Title: Kinetic characterization and phylogenetic analysis of human ADP-dependent glucokinase reveal new insights into its regulatory properties.
  2. ADPGK-AS1 promotes the progression of colorectal cancer via sponging miR-525 to upregulate FUT1.
    Title: ADPGK-AS1 promotes the progression of colorectal cancer via sponging miR-525 to upregulate FUT1.
  3. ADP-dependent glucokinase as a novel onco-target for haematological malignancies.
    Title: ADP-dependent glucokinase as a novel onco-target for haematological malignancies.
  4. ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing.
    Title: ADP-dependent glucokinase regulates energy metabolism via ER-localized glucose sensing.
  5. ADPGK is substrate inhibited by high glucose concentration and shows high specificity for glucose, with no activity for other sugars, as determined by NMR spectroscopy, including 2-deoxyglucose
    Title: The Structural and Functional Characterization of Mammalian ADP-dependent Glucokinase.
  6. ADPGK can contribute to tumour cell survival under conditions of high glycolytic dependence.
    Title: Zinc finger nuclease mediated knockout of ADP-dependent glucokinase in cancer cell lines: effects on cell survival and mitochondrial oxidative metabolism.
  7. human ADPGK(ADP-dependent glucokinase) catalyses ADP-dependent phosphorylation of glucose in vitro, but despite its high expression in human tumour cell lines it appears not to make a quantifiable contribution to glycolysis under the conditions evaluated.
    Title: Expression and role in glycolysis of human ADP-dependent glucokinase.
  8. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  9. Glucose and insulin response to oral glucose is higher in GCK(261) carriers, indicating clinical heterogeneity in GCK maturity diabetes carriers.
    Title: Clinical heterogeneity in monogenic diabetes caused by mutations in the glucokinase gene (GCK-MODY).
  10. The presence of mild persistent hyperglycemia in any patient without autoantibodies should lead to genetic analysis of glucokinase, particularly if there is a positive family history.
    Title: Mild fasting hyperglycemia in children: high rate of glucokinase mutations and some risk of developing type 1 diabetes mellitus.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • DKFZp434B195

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ADP-specific glucokinase activity EXP
Inferred from Experiment
more info
 PubMed 
enables ADP-specific glucokinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ADP-specific glucokinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glucose metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within glucose metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in glycolytic process through glucose-6-phosphate TAS
Traceable Author Statement
more info
  
involved_in phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
  
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in membrane HDA PubMed 

General protein information

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Preferred Names
ADP-dependent glucokinase
Names
ATP-dependent glucokinase
rbBP-35
NP_001352152.1
NP_001352153.1
NP_001352154.1
NP_001352155.1
NP_001352156.1
NP_001352157.1
NP_001352158.1
NP_112574.3
XP_011520406.1
XP_016878153.1
XP_047289120.1
XP_054234954.1
XP_054234955.1
XP_054234956.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001365223.1 → NP_001352152.1  ADP-dependent glucokinase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC009712, AK075560, BC044589, DA031990, DA208247
    UniProtKB/TrEMBL
    B4DDP8
    Conserved Domains (1) summary
    cd01938
    Location:1 → 369
    ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

  2. NM_001365224.1 → NP_001352153.1  ADP-dependent glucokinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009712, AK055526, AK075560
    UniProtKB/TrEMBL
    Q69YR1
    Conserved Domains (1) summary
    cl00192
    Location:1 → 253
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

  3. NM_001365225.1 → NP_001352154.1  ADP-dependent glucokinase isoform 4 precursor

    Status: VALIDATED

    Source sequence(s)
    AC009712, BC006112, DA031990
    Consensus CDS
    CCDS92041.1
    UniProtKB/Swiss-Prot
    Q49AU7, Q8NBI1, Q8WZ90, Q96NF8, Q9BRR6, Q9H0A7
    UniProtKB/TrEMBL
    B4DG35
    Related
    ENSP00000397694.3, ENST00000456471.3
    Conserved Domains (1) summary
    cd01938
    Location:60 → 492
    ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

  4. NM_001365226.1 → NP_001352155.1  ADP-dependent glucokinase isoform 5

    Status: VALIDATED

    Source sequence(s)
    AC009712
    UniProtKB/TrEMBL
    B4DDP8
    Conserved Domains (1) summary
    cd01938
    Location:1 → 370
    ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

  5. NM_001365227.1 → NP_001352156.1  ADP-dependent glucokinase isoform 6 precursor

    Status: VALIDATED

    Source sequence(s)
    AC009712, BI906568
    Conserved Domains (1) summary
    cl00192
    Location:60 → 353
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

  6. NM_001365228.1 → NP_001352157.1  ADP-dependent glucokinase isoform 7 precursor

    Status: VALIDATED

    Source sequence(s)
    AC009712, DA600729
    Conserved Domains (1) summary
    cl00192
    Location:60 → 352
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

  7. NM_001365229.1 → NP_001352158.1  ADP-dependent glucokinase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC009712
    UniProtKB/TrEMBL
    Q69YR1
    Conserved Domains (1) summary
    cl00192
    Location:1 → 253
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

  8. NM_031284.5 → NP_112574.3  ADP-dependent glucokinase isoform 1 precursor

    See identical proteins and their annotated locations for NP_112574.3

    Status: VALIDATED

    Source sequence(s)
    AC009712, AK075560, DA031990, DB279245
    Consensus CDS
    CCDS42057.1
    UniProtKB/TrEMBL
    B4DG35
    Related
    ENSP00000312250.8, ENST00000311669.12
    Conserved Domains (1) summary
    cd01938
    Location:60 → 491
    ADPGK_ADPPFK; ADP-dependent glucokinase (ADPGK) and phosphofructokinase (ADPPFK). ADPGK and ADPPFK are proteins that rely on ADP rather than ATP to donate a phosphoryl group. They are found in certain hyperthermophilic archaea and in higher eukaryotes. A functional ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    72751294..72783758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522104.4 → XP_011520406.1  ADP-dependent glucokinase isoform X2

    Conserved Domains (1) summary
    cl00192
    Location:60 → 313
    ribokinase_pfkB_like; ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase, ...

  2. XM_047433164.1 → XP_047289120.1  ADP-dependent glucokinase isoform X1

  3. XM_017022664.3 → XP_016878153.1  ADP-dependent glucokinase isoform X3

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    70568596..70601068 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054378980.1 → XP_054234955.1  ADP-dependent glucokinase isoform X2

  2. XM_054378979.1 → XP_054234954.1  ADP-dependent glucokinase isoform X1

  3. XM_054378981.1 → XP_054234956.1  ADP-dependent glucokinase isoform X3

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BRR6.1 GenPept UniProtKB/Swiss-Prot:Q9BRR6

Gene LinkOut

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