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Rsph6a radial spoke head 6 homolog A (Chlamydomonas) [ Mus musculus (house mouse) ]

Gene ID: 83434, updated on 21-Apr-2024

Summary

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Official Symbol
Rsph6aprovided by MGI
Official Full Name
radial spoke head 6 homolog A (Chlamydomonas)provided by MGI
Primary source
MGI:MGI:1927643
See related
Ensembl:ENSMUSG00000040866 AllianceGenome:MGI:1927643
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
RSP4; Rshl1
Summary
Involved in manchette disassembly and motile cilium assembly. Located in axoneme and sperm flagellum. Orthologous to human RSPH6A (radial spoke head 6 homolog A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 80.9) See more
Orthologs
human all
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Genomic context

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Location:
7 A3; 7 9.46 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (18788603..18808384)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (19054678..19074447)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene forkhead box A3 Neighboring gene symplekin Neighboring gene STARR-positive B cell enhancer ABC_E8152 Neighboring gene dystrophia myotonica-containing WD repeat motif Neighboring gene microRNA 3100 Neighboring gene dystrophia myotonica-protein kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. CRISPR/CAS9-mediated amino acid substitution reveals phosphorylation residues of RSPH6A are not essential for male fertility in mice†. Miyata H, et al. Biol Reprod, 2020 Oct 29. PMID 32901808, Free PMC Article
  2. Sperm capacitation is associated with phosphorylation of the testis-specific radial spoke protein Rsph6a†. Paudel B, et al. Biol Reprod, 2019 Feb 1. PMID 30239614, Free PMC Article
  3. A mammalian radial spokehead-like gene, RSHL1, at the myotonic dystrophy-1 locus. Eriksson M, et al. Biochem Biophys Res Commun, 2001 Mar 9. PMID 11237735
  4. Distinct architecture and composition of mouse axonemal radial spoke head revealed by cryo-EM. Zheng W, et al. Proc Natl Acad Sci U S A, 2021 Jan 26. PMID 34871179, Free PMC Article
  5. RSPH6A is required for sperm flagellum formation and male fertility in mice. Abbasi F, et al. J Cell Sci, 2018 Oct 11. PMID 30185526, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in axoneme assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium movement IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cilium movement involved in cell motility IEA
Inferred from Electronic Annotation
more info
  
involved_in flagellated sperm motility IC
Inferred by Curator
more info
 PubMed 
involved_in manchette disassembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mating IC
Inferred by Curator
more info
 PubMed 
involved_in sperm flagellum assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in axoneme IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in axoneme IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in motile cilium IEA
Inferred from Electronic Annotation
more info
  
part_of radial spoke IDA
Inferred from Direct Assay
more info
 PubMed 
part_of radial spoke head IDA
Inferred from Direct Assay
more info
 PubMed 
part_of radial spoke head IPI
Inferred from Physical Interaction
more info
 PubMed 
part_of radial spoke head ISA
Inferred from Sequence Alignment
more info
 PubMed 
located_in sperm flagellum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
radial spoke head protein 6 homolog A
Names
radial spoke head-like protein 1
radial spokehead-like 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001159671.2 → NP_001153143.1  radial spoke head protein 6 homolog A isoform 2

    See identical proteins and their annotated locations for NP_001153143.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an exon in the coding region compared to variant 1. The resulting protein (isoform 2) is shorter but has the identical N- and C-termini compared to isoform 1.
    Source sequence(s)
    AC170864
    Consensus CDS
    CCDS52052.1
    UniProtKB/Swiss-Prot
    Q8CDR2
    UniProtKB/TrEMBL
    Q99MM9
    Related
    ENSMUSP00000076153.6, ENSMUST00000076887.6
    Conserved Domains (1) summary
    pfam04712
    Location:289 → 426
    Radial_spoke; Radial spokehead-like protein

  2. NM_001415787.1 → NP_001402716.1  radial spoke head protein 6 homolog A isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC170864

  3. NM_031255.3 → NP_112545.2  radial spoke head protein 6 homolog A isoform 1

    See identical proteins and their annotated locations for NP_112545.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC170864
    Consensus CDS
    CCDS20887.1
    UniProtKB/Swiss-Prot
    Q8CDR2, Q99MM8, Q99MM9
    UniProtKB/TrEMBL
    B2RQM5
    Related
    ENSMUSP00000046526.5, ENSMUST00000035521.11
    Conserved Domains (1) summary
    pfam04712
    Location:191 → 681
    Radial_spoke; Radial spokehead-like protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    18788603..18808384
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006540443.3 → XP_006540506.1  radial spoke head protein 6 homolog A isoform X1

    Conserved Domains (1) summary
    pfam04712
    Location:194 → 630
    Radial_spoke; Radial spokehead-like protein

  2. XM_006540444.2 → XP_006540507.1  radial spoke head protein 6 homolog A isoform X2

    Conserved Domains (1) summary
    pfam04712
    Location:194 → 629
    Radial_spoke; Radial spokehead-like protein
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8CDR2.1 GenPept UniProtKB/Swiss-Prot:Q8CDR2

Gene LinkOut

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